pharmacophore.Pharma-ID

pharmacophore/metadata/Gene-Name

pharmacophore/metadata/Uniprot-AC

pharmacophore/metadata/Kegg-Identifier

pharmacophore/metadata/Target-Class

pharmacophore/metadata/Target-Class-A

pharmacophore/metadata/Target-Class-B

pharmacophore/metadata/Target-Class-C

pharmacophore/metadata/Target-Class-D

pharmacophore/metadata/pdb.complex_id

pharmacophore/metadata/Taxonomic-ID

pharmacophore.name

pharmacophore.selectivity_index

pharmacophore/metadata/drug-classification

pharmacophore/metadata/target

pharmacophore/metadata/target-subclass

pharmacophore/metadata/target-family

pharmacophore/metadata/target-acronym

pharmacophore/metadata/therapeutic-classification

pharmacophore/metadata/mode-of-action

pharmacophore/metadata/pdb.ligand_id

pharmacophore/metadata/pdb.resolution

pharmacophore/actives/molecule.name

pharmacophore/actives/molecule.smiles

pharmacophore/actives/molecule.registry

pharmacophore/actives/molecule.regtype

pharmacophore/bibliography/reference.title

pharmacophore/bibliography/reference.author

pharmacophore/bibliography/reference.source

pharmacophore/bibliography/reference.year

pharmacophore/bibliography/reference.doi

1a42

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1a42

1a69

DEOD_ECOLI

P0ABP8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1a69

1a85

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

1a85

1a86

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

1a86

1a9p

PNPH_BOVIN

P55859

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1a9p

1a9s

PNPH_BOVIN

P55859

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1a9s

1add

ADA_MOUSE

P03958

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1add

1afq

CTRA_BOVIN

P00766

KO_id not found

Others

1afq

1ag9

FLAV_ECOLI

P61949

K03839

Others

1ag9

83333

1agw

FGFR1_HUMAN

P11362

K04362

Heparan sulfate-heparin binding proteins

Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis

FGFR1; fibroblast growth factor receptor 1 Mitogenesis

Others

1agw

1ahb

RIP1_MOMCH

P16094

KO_id not found

Others

1ahb

1apw

PENP_PENJA

P00798

KO_id not found

Others

1apw

1aqj

MTTA_THEAQ

P14385

KO_id not found

Others

1aqj

1b3d

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1b3d

1b8n

PNPH_BOVIN

P55859

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1b8n

1b8o

PNPH_BOVIN

P55859

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1b8o

1b8y

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1b8y

1b9i

O52552_AMYMD

O52552

KO_id not found

Others

1b9i

1bb7

LYSC2_ONCMY

P11941

KO_id not found

Others

1bb7

1bh6

SUBD_BACLI

P00781

KO_id not found

Others

1bh6

1biw

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1biw

Signaling proteins

1bjy

1bjy-ctc-2.70-d-1

399

antiinfective

tetracycline repressor protein

Intracellular transduction

DNA repressors

TetR

fundamental research
bacterial infection

resistance to tetracycline antibiotics at the transcriptional level

ctc

2.70

7-chlorotetracycline

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O

57-62-5

cas

Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction

Orth P, Saenger W, Hinrichs W

Biochemistry 38(1):191-8

1999

10.1021/bi9816610

1bkc

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

1bkc

1bmk

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1bmk

1bnn

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1bnn

1bnt

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1bnt

1bnu

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1bnu

1bnv

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1bnv

Enzymes

1br5

1br5-neo-2.50-h-1

171

antidote

ricin a chain

EC3.- (hydrolases)

glycosylases

ricin

antidot

Neopterin inhibits the Ricin A chain with Ki 2 mM54. The
aminopteridinone scaffold is situated in an aromatic cage built by
TYR80, PHE93, and TYR123 (Figure 36). An extensive hydrogen bond network
is established to SER176 and ARG180 by the oxygen as well as by several
nitrogen atoms to VAL81, GLY121, and TYR123. The glycerol moiety links
to GLU177 and GLU208, and indirectly via a water molecule to GLY212.

neo

2.50

2009-64-5

Nc1nc2ncc(nc2c(=O)[nH]1)[C@@H](O)[C@H](O)CO

D-Neopterin

CAS

Structure-based identification of a ricin inhibitor

Yan X, Hollis T, Svinth M, Day P, Monzingo AF, Milne GW, Robertus JD

J Mol Biol 266(5):1043-9

1997

10.1006/jmbi.1996.0865

1bu5

FLAV_DESVH

P00323

K05278

Enzymes

Oxidoreductases

Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2

With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Flavonol synthase

1bu5

1byg

CSK_HUMAN

P41240

K05728

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

1byg

Enzymes

1bzc

1bzc-tpi-2.35-h-1

183

endocrine

protein tyrosine phosphatase 1B

EC3.- (hydrolases)

phosphatases

PTP 1B

diabetes
obesity

dephosphorylation of insulin receptor and insulin receptor substrate tyrosine residues
prevention of insulin resistance

tpi

2.35

219316-40-2

NC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc2cc(ccc2c1)C(F)(F)P(=O)(O)O

219316-40-2

CAS

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

Groves MR, Yao ZJ, Roller PP, Burke TR Jr, Barford D

Biochemistry 37(51):17773-83

1998

Enzymes

1bzj

1bzj-pic-2.25-h-1

1674

endocrine

protein tyrosine phosphatase 1B

EC3.- (hydrolases)

phosphatases

PTP 1B

diabetes
obesity

dephosphorylation of insulin receptor and insulin receptor substrate tyrosine residues
prevention of insulin resistance

pic

2.25

219316-39-9

OC(=O)c1ccc2cc(ccc2c1)C(F)(F)P(=O)(O)O

219316-39-9

CAS

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

Groves MR, Yao ZJ, Roller PP, Burke TR Jr, Barford D

Biochemistry 37(51):17773-83

1998

1bzs

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

1bzs

1c1c

POL_HV1H2

P04585

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1c1c

1c1d

Q59771_RHOSO

Q59771

KO_id not found

Others

1c1d

1c3x

PUNA_CELSP

P81989

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1c3x

1c7s

CHB_SERMA

Q54468

KO_id not found

Others

1c7s

1c8v

TRPA_SALTY

P00929

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

1c8v

1c9k

COBU_SALTY

Q05599

K02231

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Adenosylcobinamide kinase

1c9k

1cbf

CBIF_BACME

O87696

KO_id not found

Others

1cbf

1cg6

MTAP_HUMAN

Q13126

K00772

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

S-methyl-5'-thioadenosine phosphorylase

1cg6

1cgk

CHS2_MEDSA

P30074

K00698

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Chitin synthase

1cgk

1coy

CHOD_BREST

P22637

K10078 (inferred by homologyHUMAN)

Glycan Binding Proteins

C-Type lectin

Group 8 Layilin and related receptors

CHODL; chondrolectin

Cholesterol oxidase

1coy

1702

1cw2

TRPA_SALTY

P00929

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

1cw2

1cx4

KAP3_RAT

P12369

K04739

Others

Organismal Systems

Endocrine system

Insulin signaling pathway

PRKAR; cAMP-dependent protein kinase regulator

1cx4

1d2s

SHBG_HUMAN

P04278

KO_id not found

Others

1d2s

1d4a

NQO1_HUMAN

P15559

K00355

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With a quinone or similar compound as acceptor

NAD(P)H dehydrogenase (quinone)

1d4a

1d4h

POL_HV1B1

P03366

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1d4h

1d4i

POL_HV1B1

P03366

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1d4i

1d4l

POL_HV1A2

P03369

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1d4l

Enzymes

1d5l

1d5l-cyn-1.90-x-1

841

immunologic

myeloperoxidase

EC1.- (oxydo-reductases)

peroxydases

myeloperoxidase

cognitive defects
cardiovascular diseases
cancer
multiple sclerosis
COPD
inflammation

modulation of HOCl generation at sites of inflammation

cyn

1.90

salicylhydroxamic acid

ONC(=O)c1ccccc1O

89-73-6

cas

Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution

Blair-Johnson M, Fiedler T, Fenna R

Biochemistry 40(46):13990-7

2001

10.1021/bi0111808

1d6s

CYSK_SALTI

P0A1E4

K01738

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Cysteine synthase

1d6s

1d7u

DGDA_BURCE

P16932

KO_id not found

Enzymes

4. Lyases

decarboxylases

DGD (bacterial)

Others

1d7u

1d7x

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1d7x

1d8f

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1d8f

1dht

DHB1_HUMAN

P14061

K00044

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Estradiol 17beta-dehydrogenase

1dht

1dig

C1TC_HUMAN

P11586

K00288

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Formate---tetrahydrofolate ligase

1dig

1djn

DHTM_METME

P16099

KO_id not found

Others

1djn

1dl5

PIMT_THEMA

Q56308

K00573

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1dl5

Enzymes

1dm2

1dm2-hmd-2.10-h-1

1681

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

hmd

2.10

Hymenialdisine

NC1=NC(=O)/C(=C/2\CCNC(=O)c3[nH]c(Br)cc23)/N1

82005-12-7

CAS

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR

Chem Biol 7(1):51-63

2000

10.1016/S1074-5521(00)00063-6

1dqn

Q24973_GIAIN

Q24973

KO_id not found

Enzymes

2. Transferases

phosphoribosyl transferases

GPRTase (G.lambia)

Others

1dqn

1dth

VM1AD_CROAT

P15167

KO_id not found

Others

1dth

Enzymes

1e1x

1e1x-nw1-1.85-h-1

1335

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

nw1

1.85

NU 6027

Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1

220036-08-8

CAS

Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles

Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Garman EF, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury P, Johnson LN, Lawrie AM, Newell DR, Noble ME, Sausville EA, Schultz R, Yu W

J Med Chem 43(15):2797-804

2000

10.1021/jm990628o

1e1x

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1e1x

Enzymes

1e2k

1e2k-tmc-1.70-d-1-s

1061

antiinfective

herpes simplex virus thymidine kinase

EC2.- (transferases)

kinases (thymidine)

TK (HSV1)

herpes infection

phosphorylation of prodrug, inhibition of viral DNA polymerase

tmc

1.7

2'-exo-methanocarba-thymidine

Cc1cn([C@H]2C[C@H](O)[C@]3(CO)C[C@H]23)c(=O)[nH]c1=O

156126-12-4

cas

Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine

Prota, A., Vogt, J., Pilger, B., Perozzo, R., Wurth, C., Marquez, V., Russ, P., Schulz, G. E., Folkers, G., Scapozza, L.

Biochemistry 39 pp. 9597

2000

1e2k

KITH_HHV11

P03176

K00857

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Thymidine kinase

1e2k

Enzymes

1e2l

1e2l-tmc-2.40-d-1

3.53989290283855

antiinfective

Herpes simplex virus thymidine kinase

EC2.- (transferases)

kinases (thymidine)

TK (HSV1)

herpes infection

substrate of viral thymidine kinase thereby activation of prodrug
termination of viral DNA elongation at the viral DNA polymerase

tmc

2.40

156126-12-4

Cc1cn([C@H]2C[C@H](O)[C@]3(CO)C[C@H]23)c(=O)[nH]c1=O

156126-12-4

cas

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

Prota A, Vogt J, Pilger B, Perozzo R, Wurth C, Marquez VE, Russ P, Schulz GE, Folkers G, Scapozza L

Biochemistry 39(31):9597-603

2000

10.1021/bi000668q

1e2n

KITH_HHV11

P03176

K00857

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Thymidine kinase

1e2n

1e5d

ROO_DESGI

Q9F0J6

KO_id not found

Others

1e5d

1e81

CARP_CRYPA

P11838

K01381

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Saccharopepsin

1e81

1e82

CARP_CRYPA

P11838

K01381

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Saccharopepsin

1e82

1e8h

VAOX_PENSI

P56216

KO_id not found

Others

1e8h

1e8m

PPCE_PIG

P23687

K01322

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Prolyl oligopeptidase

1e8m

1e8w

PK3CG_PIG

O02697

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

1e8w

1e90

PK3CG_PIG

O02697

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

1e90

Enzymes

1e9h

1e9h-inr-2.50-h-1

10.07159

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

inr

2.50

478283-10-2

[C=1C=CC2=C(C1)C(=O)\C(=C\3/C=4C=C(C=CC4NC3=O)S(=O)(=O)O)\N2]

478283-10-2

CAS

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate.

Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble ME.

Structure 9(5):389-97

2001

10.1016/S0969-2126(01)00598-6

1ebw

POL_HV1B1

P03366

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1ebw

1ebz

POL_HV1B1

P03366

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1ebz

1ec1

POL_HV1B1

P03366

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1ec1

1ec2

POL_HV1B1

P03366

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1ec2

1ecj

PUR1_ECOLI

P0AG16

K00764

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Amidophosphoribosyltransferase

1ecj

Enzymes

1ecv

1ecv-878-1.95-d-2

1843

endocrine

protein tyrosine phosphatase 1B

EC3.- (hydrolases)

phosphatases

PTP 1B

diabetes
obesity

dephosphorylation of insulin receptor and insulin receptor substrate tyrosine residues
prevention of insulin resistance

878

1.95

243989-50-6

OC(=O)C(=O)Nc1ccc(I)cc1C(=O)O

243989-50-6

cas

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

Andersen HS, Iversen LF, Jeppesen CB, Branner S, Norris K, Rasmussen HB, Moller KB, Moller NP

J Biol Chem 275(10):7101-8

2000

1eed

CARP_CRYPA

P11838

K01381

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Saccharopepsin

1eed

Toxins and defence proteins

1eei

1eei-gaa-2.00-d-1

1589

antiinfective

cholera toxin

Toxins

bacterial toxins

toxin (cholera)

diarrhoea

inhibition of cell receptor binding by toxin
interference with bacterial toxin entry into host cell

gaa

2.00

52571-71-8

OC[C@H]1O[C@H](Oc2cccc(c2)N(=O)=O)[C@H](O)[C@@H](O)[C@H]1O

52571-71-8

cas

Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives

Fan E, Merritt EA, Zhang Z, Pickens JC, Roach C, Ahn M, Hol WG

Acta Crystallogr D Biol Crystallogr 57(Pt 2):201-12

2001

10.1107/S0907444900016814

1eet

POL_HV1B1

P03366

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1eet

Enzymes

1ef3

1ef3-fid-2.80-f-1-s

0.180462341536167

endocrine

aldose reductase

EC1.- (oxydo-reductases)

aldehyde reductases

ALR2

antidiabetic

catalyzes the NADPH-dependent reduction of aldehydes to their corresponding alcohols

fid

2.80

fidarestat

NC(=O)[C@H]3C[C@@]1(NC(=O)NC1=O)c2cc(F)ccc2O3

136087-85-9

CAS

Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors

El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A

Proteins 55(4):805-13

2004

10.1002/prot.20001

1efy

PARP1_CHICK

P26446

K10798

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

1efy

1ej3

AEQ2_AEQVI

P02592

KO_id not found

Others

1ej3

1eje

P152_METTH

O26255

KO_id not found

Others

1eje

1ek2

HYES_MOUSE

P34914

K08726

Enzymes

Hydrolases

Acting on ether bonds

Ether hydrolases

Soluble epoxide hydrolase

1ek2

1el3

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

1el3

1el4

OBL_OBELO

Q27709

KO_id not found

Others

1el4

1eno

FABI_BRANA

P80030

K00208

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With NAD+ or NADP+ as acceptor

Enoyl-[acyl-carrier-protein] reductase (NADH)

1eno

1eou

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1eou

1epq

CARP_CRYPA

P11838

K01381

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Saccharopepsin

1epq

1esw

MALQ_THETH

O87172

K00705

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

4-alpha-glucanotransferase

1esw

1f4p

FLAV_DESVH

P00323

K05278

Enzymes

Oxidoreductases

Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2

With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Flavonol synthase

1f4p

1f8g

PNTAA_RHORT

Q2RSB2

K00324

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With NAD+ or NADP+ as acceptor

NAD(P)+ transhydrogenase (AB-specific)

1f8g

1fbo

GUNF_CLOCE

P37698

KO_id not found

Others

1fbo

1fhd

GUX_CELFI

P07986

KO_id not found

Others

1fhd

1fkh

FKB1A_HUMAN

P62942

K09568

Enzymes

Isomerases

Cis-trans-Isomerases

Cis-trans Isomerases (only sub-subclass identified to date)

Peptidylprolyl isomerase

1fkh

1fkw

ADA_MOUSE

P03958

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1fkw

1fm7

CFI1_MEDSA

P28012

K01859

Enzymes

Isomerases

Intramolecular lyases

Intramolecular lyases (only sub-subclass identified to date)

Chalcone isomerase

1fm7

Receptors

1fm9

1fm9-570-2.10-x-1

617

metabolic

peroxisome proliferator-activated receptor gamma

Transduction factor receptors

nuclear hormone receptors

PPAR-gamma

metabolic syndrome
diabetes
cardiovascular diseases
obesity

activation of peroxisome proliferator-activated receptor gamma
central regulator of adipocyte differentiation, fatty acid metabolism and glucose homeostasis; inhibition of inflammatory cytokines and other proteins

570

2.10

farglitazar

Cc1oc(nc1CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c4ccccc4)C(=O)O)cc2)c5ccccc5

196808-45-4

CAS

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE

Mol Cell 5(3):545-55

2000

10.1016/S1097-2765(00)80448-7

Receptors

1fm9

1fm9-570-2.10-x-2

276

metabolic

peroxisome proliferator-activated receptor gamma

Transduction factor receptors

nuclear hormone receptors

PPAR-gamma

metabolic syndrome
diabetes
cardiovascular diseases
obesity

570

2.10

farglitazar

Cc1oc(nc1CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c4ccccc4)C(=O)O)cc2)c5ccccc5

196808-45-4

CAS

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE

Mol Cell 5(3):545-55

2000

10.1016/S1097-2765(00)80448-7

1fmo

KAPCA_MOUSE

P05132

K04345

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

CAMP-dependent protein kinase

1fmo

Enzymes

1fsg

1fsg-9dg-1.05-d-1

2196

antiinfective

toxoplasma gondii hypoxanthine phosphoribosyltransferase

EC2.- (transferases)

phosphoribosyl transferases

HGPRTase (T.gondii)

parasitic infection

inhibition of parasitic hypoxanthine phosphoribosyltransferase
purine salvage from host for parasitic RNA and DNA synthesis

9dg

1.05

9-deazaguanine

NC2=NC(=O)C1N=CCC1=N2

65996-58-9

cas

Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis

Heroux A, White EL, Ross LJ, Kuzin AP, Borhani DW

Structure Fold Des 8(12):1309-18

2000

10.1016/S0969-2126(00)00546-3

1ftl

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

1ftl

Enzymes

1fvt

1fvt-106-2.20-h-1

0.88441

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

106

2.20

222035-13-4

[C=1C=C(C=CC1NN=C2C3=CC(=CC=C3NC2=O)Br)S(=O)(=O)N]

222035-13-4

CAS

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

Davis, S.T., Benson, B.G., Bramson, H.N., Chapman, D.E., Dickerson, S.H., Dold, K.M., Eberwein, D.J., Edelstein, M., Frye, S.V., Gampe Jr, R.T., Griffin, R.J., Harris, P.A., Hassell, A.M., Holmes, W.D., Hunter, R.N., Knick, V.B., Lackey, K., Lovejoy, B., Luzzio, M.J., Murray, D., Parker, P., Rocque, W.J., Shewchuk, L., Veal, J.M., Walker, D.H., Kuyper, L.F.

Science 291:134-137

2001

10.1126/science.291.5501.134

1fwk

KHSE_METJA

Q58504

K00872

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Homoserine kinase

1fwk

1fxo

Q9HU22_PSEAE

Q9HU22

K00973

Enzymes

Transferases

Transferring phosphorus-containing groups

Nucleotidyltransferases

Glucose-1-phosphate thymidylyltransferase

1fxo

1fxu

PNPH_BOVIN

P55859

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1fxu

Enzymes

1g27

1g27-bb1-2.10-d-1

1746

antiinfective

escherichia coli formylmethionine deformylase

EC3.- (hydrolases)

amidases

PDF (E.coli)

bacterial infection
fundamental research

inhibition of formyl removal from growing polypeptide N-terminus (methionine)
interference with bacterial protein synthesis

bb1

2.10

BB-3479

CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C

235784-88-0

cas

Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor

Clements JM, Beckett RP, Brown A, Catlin G, Lobell M, Palan S, Thomas W, Whittaker M, Wood S, Salama S, Baker PJ, Rodgers HF, Barynin V, Rice DW, Hunter MG

Antimicrob Agents Chemother 45(2):563-70

2001

10.1128/AAC.45.2.563-570.2001

1g27

DEF_ECOLI

P0A6K3

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

1g27

1g49

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1g49

Enzymes

1g5s

1g5s-i17-2.60-h-1

4.25652

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

i17

2.60

714963-24-3

[C=1C=CC(=CC1)CNC=2C3=C(N=C(N2)NC4CCC(CC4)N)N(C=N3)C5CCCC5]

714963-24-3

CAS

Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717

Dreyer MK, Borcherding DR, Dumont JA, Peet NP, Tsay JT, Wright PS, Bitonti AJ, Shen J, Kim SH

J Med Chem 44(4):524-530

2001

10.1021/jm001043t

1g63

EPID_STAEP

P30197

KO_id not found

Others

1g63

1g8o

GGTA1_BOVIN

P14769

K00743

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

N-acetyllactosaminide 3-alpha-galactosyltransferase

1g8o

1g9s

HPRT_ECOLI

P0A9M2

K00760

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Hypoxanthine phosphoribosyltransferase

1g9s

1gg5

NQO1_HUMAN

P15559

K00355

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With a quinone or similar compound as acceptor

NAD(P)H dehydrogenase (quinone)

1gg5

1gii

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1gii

1gs4

ANDR_HUMAN

P10275

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

1gs4

Enzymes

1gu1

1gu1-fa1-1.80-d-1

0.12527964

antiinfective

bacterial 3-dehydroquinate dehydratase

EC4.- (lyases)

hydro-lyases

type II DHQase (S.coelicolor)

bacterial infection

inhibition of bacterial 3-dehydroquinate dehydratase
interference with biosynthetic shikimate pathway
interference with biosynthesis of aromatic compounds

fa1

1.80

227002-11-1

O=C(O)[C@]1(O)C=C[C@@H](O)[C@H](O)C1

227002-11-1

cas

The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor

Roszak AW, Robinson DA, Krell T, Hunter IS, Fredrickson M, Abell C, Coggins JR, Lapthorn AJ

Structure 10(4):493-503

2002

10.1016/S0969-2126(02)00747-5

1gvt

CARP_CRYPA

P11838

K01381

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Saccharopepsin

1gvt

1gx1

ISPF_ECO57

P62618

K01770

Enzymes

Lyases

Phosphorus-oxygen lyases

Phosphorus-oxygen lyases (only sub-subclass identified to date)

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

1gx1

Enzymes

1h00

1h00-fap-1.60-h-1

0.81730

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

fap

1.60

620629-44-9

[CN(C)C[C@@H](COC1=CC=C(C=C1)NC2=CC(=NC=N2)NC3=C(C=CC=C3F)F)O]

620629-44-9

CAS

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines

Beattie, J.F., Breault, G.A., Ellston, R.P., Green, S., Jewsbury, P.J., Midgley, C.J., Naven, R.T., Minshull, C.A., Pauptit, R.A., Tucker, J.A., Pease, J.E.

Bioorg Med Chem Lett 13:2955-2960

2003

10.1016/S0960-894X(03)00202-6

Enzymes

1h0r

1h0r-fa1-2.10-d-1

0.07307979

antiinfective

bacterial 3-dehydroquinate dehydratase

EC4.- (lyases)

hydro-lyases

type II DHQase (M.tuberculosis)

tuberculosis
bacterial infection

inhibition of bacterial 3-dehydroquinate dehydratase
interference with biosynthetic shikimate pathway
interference with biosynthesis of aromatic compounds

fa1

2.10

227002-11-1

O=C(O)[C@]1(O)C=C[C@@H](O)[C@H](O)C1

227002-11-1

cas

Structural Basis for Specificity of Oxime Based Inhibitors Towards Type II Dehydroquinase from Mycobacterium Tuberculosis

Robinson DA, Roszak AW, Frederickson M, Abell C, Coggins JR, Lapthorn AJ

to be published

2003

Enzymes

1h1q

1h1q-2a6-2.5-h-1-s

323

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

2a6

2.50

NU 6094

C(Oc1nc(Nc2ccccc2)nc3[nH]cnc13)C4CCCCC4

444722-80-9

CAS

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Davies TG, Bentley J, Arris CE, Boyle FT, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Hardcastle IR, Jewsbury P, Johnson LN, Mesguiche V, Newell DR, Noble ME, Tucker JA, Wang L, Whitfield HJ

Nat Struct Biol 9(10):745-9

2002

10.1038/nsb842

Enzymes

1h1s

1h1s-4sp-2.0-h-1

449

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

4sp

2.00

NU 6102

NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c4nc[nH]c4n2)cc1

444722-95-6

CAS

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Nat Struct Biol 9(10):745-9

2002

10.1038/nsb842

1h1s

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1h1s

1h2h

ASPD_THEMA

Q9X1X6

K06989

Enzymes

Oxidoreductases

Acting on the CH-NH2 group of donors

With NAD+ or NADP+ as acceptor

Aspartate dehydrogenase

1h2h

1h69

NQO1_HUMAN

P15559

K00355

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With a quinone or similar compound as acceptor

NAD(P)H dehydrogenase (quinone)

1h69

1h8d

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

1h8d

Transport proteins

1h9z

1h9z-rwf-2.50-h-1

13576

immunologic

Serum albumin

extracellular proteins

serum proteins

HSA

inflammation

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.

rwf

2.50

(S)-Warfarin

CC(=O)C[C@H](c1ccccc1)c2c(O)c3ccccc3oc2=O

5543-57-7

CAS

Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I

Petitpas I, Bhattacharya AA, Twine S, East M, Curry S

J Biol Chem 276(25):22804-9

2001

10.1074/jbc.M100575200

Transport proteins

1ha2

1ha2-swf-2.50-h-1-s

1310

immunologic

Serum albumin

extracellular proteins

serum proteins

HSA

inflammation

swf

2.50

(R)-Warfarin

CC(=O)C[C@@H](c1ccccc1)c2c(O)c3ccccc3oc2=O

5543-58-8

CAS

Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I

Petitpas I, Bhattacharya AA, Twine S, East M, Curry S

J Biol Chem 276(25):22804-9

2001

10.1074/jbc.M100575200

Transport proteins

1ha2

1ha2-swf-2.50-h-1

12247

immunologic

Serum albumin

extracellular proteins

serum proteins

HSA

inflammation

swf

2.50

(R)-Warfarin

CC(=O)C[C@@H](c1ccccc1)c2c(O)c3ccccc3oc2=O

5543-58-8

CAS

Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I

Petitpas I, Bhattacharya AA, Twine S, East M, Curry S

J Biol Chem 276(25):22804-9

2001

10.1074/jbc.M100575200

1hgx

HGXR_TRIFO

P51900

KO_id not found

Others

1hgx

1hon

PURA_ECOLI

P0A7D4

K01939

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Adenylosuccinate synthase

1hon

1hpg

Q54211_STRGR

Q54211

KO_id not found

Others

1hpg

1hpo

POL_HV1BR

P03367

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1hpo

1hpx

POL_HV1BR

P03367

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1hpx

1hy7

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1hy7

1hyh

DHL2_LACCO

P14295

KO_id not found

Others

1hyh

1i73

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

1i73

1i8z

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1i8z

1i90

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1i90

Enzymes

1ia1

1ia1-tq3-1.70-d-1

2425

antiinfective

candida albicans dihydrofolate reductase

EC1.- (oxydo-reductases)

dihydrofolate reductases

DHFR (C.albicans)

fungal infection

inhibition of fungal dihydrofolate reductase
reduction of tetrahydrofolate

tq3

1.70

123241-99-6

Nc1nc(N)c2c(Sc3ccccc3)cccc2n1

123241-99-6

cas

X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor

Whitlow M, Howard AJ, Stewart D, Hardman KD, Chan JH, Baccanari DP, Tansik RL, Hong JS, Kuyper LF

J Med Chem 44(18):2928-32

2001

10.1021/jm0101444

Enzymes

1ia2

1ia2-tq4-1.82-d-1-s

2024

antiinfective

candida albicans dihydrofolate reductase

EC1.- (oxydo-reductases)

dihydrofolate reductases

DHFR (C.albicans)

fungal infection

inhibition of fungal dihydrofolate reductase
reduction of tetrahydrofolate

tq4

1.82

168910-32-5

Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1

168910-32-5

cas

X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor

Whitlow M, Howard AJ, Stewart D, Hardman KD, Chan JH, Baccanari DP, Tansik RL, Hong JS, Kuyper LF

J Med Chem 44(18):2928-32

2001

10.1021/jm0101444

1if9

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1if9

1ij8

AVID_CHICK

P02701

KO_id not found

Others

1ij8

1iky

POL_HV1B1

P03366

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1iky

1ish

BST1_HUMAN

Q10588

K01242

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

NAD+ nucleosidase

1ish

1isj

BST1_HUMAN

Q10588

K01242

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

NAD+ nucleosidase

1isj

Enzymes

1j2g

1j2g-aza-2.20-d-2

727

antiinfective

Bacillus sp urate oxidase

EC1.- (oxydo-reductases)

urate oxidases

Uox (Bacillus sp.)

bacterial infection
fundamental research

inhibition of bacterial urate oxidase
interference with purine degradation

aza

2.20

8-azaxanthine

O=c1[nH]c(=O)c2[nH]nnc2[nH]1

1468-26-4

cas

Crystal structure of urate oxidase from Bacillus SP

Hibi T, Nago T, Nishiya Y, Oda J

to be published

2004

1jdt

PNPH_SULSO

P50389

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1jdt

1jdv

PNPH_SULSO

P50389

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1jdv

1jdz

PNPH_SULSO

P50389

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1jdz

1je1

PNPH_SULSO

P50389

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1je1

1jiz

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

1jiz

1jk3

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

1jk3

1jla

POL_HV1H2

P04585

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1jla

1jlx

Q71QF2_AMACA

Q71QF2

KO_id not found

Others

1jlx

1jm6

PDK2_RAT

Q64536

K00898

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

[pyruvate dehydrogenase (acetyl-transferring)] kinase

1jm6

1jnq

LOX3_SOYBN

P09186

K00454

Enzymes

Oxidoreductases

Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2

With incorporation of two atoms of oxygen

Linoleate 13S-lipoxygenase

1jnq

1jot

LECA_MACPO

P18674

KO_id not found

Others

1jot

Enzymes

1jr1

1jr1-moa-2.60-d-1-s

antiinfective
oncolytic
immunologic

IMP dehydrogenase

EC1.- (oxydo-reductases)

IMP dehydrogenases

IMPDH

cancer
viral infection
autoimmune suppression
herpes infection
fundamental research

inhibition of conversion of IMP to XMP and consequently of de novo guanine nucleotide biosynthesis
depletion of the guanylate (GMP, GDP, GTP and dGTP) pools
inhibition of growth and differentiation of human lymphocytes (suppression of T and B lyphocyte proliferation)

moa

2.60

mycophenolic acid

COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O

24280-93-1

CAS

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP

Cell 85(6):921-30

1996

10.1016/S0092-8674(00)81275-1

Enzymes

1jr1

1jr1-moa-2.60-d-1

133

antiinfective
oncolytic
immunologic

IMP dehydrogenase

EC1.- (oxydo-reductases)

IMP dehydrogenases

IMPDH

cancer
viral infection
autoimmune suppression
herpes infection
fundamental research

moa

2.60

mycophenolic acid

COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O

24280-93-1

CAS

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP

Cell 85(6):921-30

1996

10.1016/S0092-8674(00)81275-1

Enzymes

1jsv

1jsv-u55-1.90-h-1

9.52573

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

u55

1.90

400611-95-2

[C=1C=C(C=CC1NC=2C=C(N=CN2)N)S(=O)(=O)N]

400611-95-2

CAS

The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism

Clare, P.M., Poorman, R.A., Kelley, L.C., Watenpaugh, K.D., Bannow, C.A., Leach, K.L.

J Biol Chem 276:48292-48299

2001

10.1074/jbc.M102034200

Enzymes

1jsv

1jsv-u55-1.96-h-1

1316

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

u55

1.95

PNU 112455A

Nc1cc(Nc2ccc(cc2)S(=O)(=O)N)ncn1

400611-95-2

CAS

The Cyclin-dependent Kinases cdk2 and cdk5 Act by a Random, Anticooperative Kinetic Mechanism

Clare PM, Poorman RA, Kelley LC, Watenpaugh KD, Bannow CA, Leach KL

J. Biol. Chem 276(51), 48292-48299

2001

10.1074/jbc.M102034200

Enzymes

1jvp

1jvp-lig-1.53-h-1

8.57867

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

lig

1.5

54714-78-2

[C=1C=CC2=C(C1)CC3=C2NN=C3C4=CC=NC=C4]

54714-78-2

CAS

Structure-based design and protein X-ray analysis of a protein kinase inhibitor

Furet, P., Meyer, T., Strauss, A., Raccuglia, S., Rondeau, J.M.

Bioorg Med Chem Lett 12:221-224

2002

10.1016/S0960-894X(01)00715-6

1jyv

BGAL_ECOLI

P00722

K12309

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Beta-galactosidase

1jyv

1jyw

BGAL_ECOLI

P00722

K12309

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Beta-galactosidase

1jyw

1k3u

TRPA_SALTY

P00929

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

1k3u

1k4g

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

1k4g

1k7f

TRPA_SALTY

P00929

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

1k7f

Enzymes

1k9s

1k9s-fm2-2.00-d-1

0.840349408438245

antiinfective

escherichia coli purine nucleoside phosphorylase

EC2.- (transferases)

nucleoside phosphorylase

PNP (E.coli)

bacterial infection

inhibition of bacterial purine nucleoside phosphorylase, an important enzyme in purine salvage pathway

fm2

2.00

502174-44-9

CN1C=NC2=C(C1=N)NN=C2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

502174-44-9

CAS

Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism

Koellner G, Bzowska A, Wielgus-Kutrowska B, Luic M, Steiner T, Saenger W, Stepinski J

J Mol Biol 315(3):351-71

2002

10.1006/jmbi.2001.5211

1kap

APRA_PSEAE

Q03023

KO_id not found

Others

1kap

1kbq

NQO1_HUMAN

P15559

K00355

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With a quinone or similar compound as acceptor

NAD(P)H dehydrogenase (quinone)

1kbq

Enzymes

1ke5

1ke5-ls1-2.20-h-1

8.68158

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

ls1

2.2

388627-55-2

[CNS(=O)(=O)C1=CC=C(C=C1)NC=C2C=3C=CC=CC3NC2=O]

388627-55-2

CAS

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis

Bramson HN, Corona J, Davis ST, Dickerson SH, Edelstein M, Frye SV, Gampe RT Jr, Harris PA, Hassell A, Holmes WD, Hunter RN, Lackey KE, Lovejoy B, Luzzio MJ, Montana V, Rocque WJ, Rusnak D, Shewchuk L, Veal JM, Walker DH, Kuyper LF

J Med Chem 44(25):4339-58

2001

10.1021/jm010117d

1ke5

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1ke5

Enzymes

1ke7

1ke7-ls3-2.00-d-1

300

oncolytic

cyclin-dependent kinase 2
CDK2

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer

inhibition of cell cycle controlling enzyme CDK2
apoptosis in tumour cells

ls3

2.00

388627-76-7

O=C/1Nc2ccc(cc2\C1=C\Nc3ccc4CS(=O)(=O)Cc4c3)c5cnco5

388627-76-7

cas

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis

J Med Chem ;44(25):4339-58

2001

10.1021/jm010117d

1ke7

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1ke7

Enzymes

1ke9

1ke9-ls5-2.00-h-1

105

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

ls5

2.00

388627-61-0

NC(=N)NS(=O)(=O)c1ccc(N/C=C/2\C(=O)Nc3ccccc23)cc1

388627-61-0

CAS

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis

J Med Chem 44(25):4339-58

2001

10.1021/jm010117d

Enzymes

1ki3

1ki3-pe2-2.37-d-1

0.799279700507053

antiinfective

Herpes simplex virus thymidine kinase

EC2.- (transferases)

kinases (thymidine)

TK (HSV1)

herpes infection

substrate of viral thymidine kinase thereby activation of prodrug
termination of viral DNA elongation at the viral DNA polymerase

pe2

2.37

penciclovir

C1=NC=2C(=O)NC(=NC2N1CCC(CO)CO)N

39809-25-1

CAS

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR

Proteins 32(3):350-61

1998

1kie

Q9GPQ4_TRYVI

Q9GPQ4

KO_id not found

Others

1kie

1klm

POL_HV1H2

P04585

KO_id not found

Others

1klm

1krv

THGA_ECOLI

P07464

K00633

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Galactoside O-acetyltransferase

1krv

1kug

VM2T3_PROMU

O57413

KO_id not found

Others

1kug

1kui

VM2T3_PROMU

O57413

KO_id not found

Others

1kui

1kuk

VM2T3_PROMU

O57413

KO_id not found

Others

1kuk

1kv1

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1kv1

1kv2

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1kv2

1kyv

RIB4_SCHPO

Q9UUB1

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

1kyv

1kyx

RIB4_SCHPO

Q9UUB1

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

1kyx

1kyy

RIB4_SCHPO

Q9UUB1

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

1kyy

1kzl

RISA_SCHPO

Q9Y7P0

K00793

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Riboflavin synthase

1kzl

1l2s

AMPC_ECOLI

P00811

K01467

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amides

Beta-lactamase

1l2s

1lcw

SAV_STRAV

P22629

KO_id not found

Others

1lcw

1lcz

SAV_STRAV

P22629

KO_id not found

Others

1lcz

1led

LEC4_GRISI

P24146

KO_id not found

Others

1led

1lho

SHBG_HUMAN

P04278

KO_id not found

Others

1lho

1lhr

PDXK_SHEEP

P82197

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

1lhr

1lhv

SHBG_HUMAN

P04278

KO_id not found

Others

1lhv

1lkd

BPHC_BURXL

P47228

K00462

Enzymes

Oxidoreductases

Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2

With incorporation of two atoms of oxygen

Biphenyl-2,3-diol 1,2-dioxygenase

1lkd

1llq

MAOM_ASCSU

P27443

K00027

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Malate dehydrogenase (oxaloacetate-decarboxylating)

1llq

Toxins and defence proteins

1llr

1llr-fng-1.46-d-1

1820

antiinfective

cholera toxin

Toxins

bacterial toxins

toxin (cholera)

diarrhoea

inhibition of cell receptor binding by toxin
interference with bacterial toxin entry into host cell

fng

1.46

INT-1llr-fng-d

Nc3c(NCCCOCCOCCOCCCNC(=O)c2cc(O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)cc(N(=O)=O)c2)c(=O)c3=O

INT-1llr-fng-d

int

Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin

Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WG, Fan E

J Am Chem Soc 124(30):8818-24

2002

10.1021/ja0202560

1lp6

PYRF_METTH

O26232

K01591

Enzymes

Lyases

Carbon-carbon lyases

Carboxy-lyases

Orotidine-5'-phosphate decarboxylase

1lp6

1lqy

DEF2_GEOSE

O31410

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

1lqy

1lry

DEF_PSEAE

Q9I7A8

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

1lry

1lsj

HCDH_HUMAN

Q16836

K00022

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

3-hydroxyacyl-CoA dehydrogenase

1lsj

1lvw

O27819_METTH

O27819

KO_id not found

Others

1lvw

1m26

LECA_ARTIN

P18670

KO_id not found

Others

1m26

1m2r

CSK2A_MAIZE

P28523

KO_id not found

Others

1m2r

Enzymes

1me7

1me7-moa-2.20-d-1

1215

antiinfective
oncolytic
immunologic

IMP dehydrogenase

EC1.- (oxydo-reductases)

IMP dehydrogenases

IMPDH

cancer
viral infection
autoimmune suppression
herpes infection
fundamental research

moa

2.20

mycophenolic acid

COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O

24280-93-1

CAS

Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site

Prosise GL, Wu JZ, Luecke H

J Biol Chem 277(52):50654-9

2002

10.1074/jbc.M208330200

Enzymes

1me8

1me8-rvp-1.90-d-1

antiinfective
oncolytic
immunologic

IMP dehydrogenase

EC1.- (oxydo-reductases)

IMP dehydrogenases

IMPDH

cancer
viral infection
autoimmune suppression
herpes infection
fundamental research

rvp

1.90

ribavirin monophosphate

NC(=O)c1ncn(n1)[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O

40925-28-8

CAS

Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site

Prosise GL, Wu JZ, Luecke H

J Biol Chem 277(52):50654-9

2002

10.1074/jbc.M208330200

1me8

IMDH_TRIFO

P50097

K00088

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

IMP dehydrogenase

1me8

1me9

IMDH_TRIFO

P50097

K00088

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

IMP dehydrogenase

1me9

Enzymes

1meh

1meh-moa-2.00-d-1

590

antiinfective
oncolytic
immunologic

IMP dehydrogenase

EC1.- (oxydo-reductases)

IMP dehydrogenases

IMPDH

cancer
viral infection
autoimmune suppression
herpes infection
fundamental research

moa

2.00

mycophenolic acid

COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O

24280-93-1

CAS

Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism

Prosise GL, Luecke H

J Mol Biol ;326(2):517-27

2003

10.1016/S0022-2836(02)01383-9

Enzymes

1mei

1mei-moa-2.20-d-1

500

antiinfective
oncolytic
immunologic

IMP dehydrogenase

EC1.- (oxydo-reductases)

IMP dehydrogenases

IMPDH

cancer
viral infection
autoimmune suppression
herpes infection
fundamental research

moa

2.20

mycophenolic acid

COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O

24280-93-1

CAS

Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism

Prosise GL, Luecke H

J Mol Biol ;326(2):517-27

2003

10.1016/S0022-2836(02)01383-9

1mf1

PURA1_MOUSE

P28650

K01939

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Adenylosuccinate synthase

1mf1

1mmb

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

1mmb

1mmp

MMP7_HUMAN

P09237

K01397

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Matrilysin

1mmp

1mmq

MMP7_HUMAN

P09237

K01397

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Matrilysin

1mmq

1mmr

MMP7_HUMAN

P09237

K01397

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Matrilysin

1mmr

1mnc

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

1mnc

1mrh

RIP1_MOMCH

P16094

KO_id not found

Others

1mrh

1mvn

HAL3A_ARATH

Q9SWE5

K01598

Enzymes

Lyases

Carbon-carbon lyases

Carboxy-lyases

Phosphopantothenoylcysteine decarboxylase

1mvn

1mvt

DYR_HUMAN

P00374

K00287

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Dihydrofolate reductase

1mvt

1mxi

TRML_HAEIN

P44868

K03216

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

TRNA (cytidine34-2'-O)-methyltransferase

1mxi

1n2i

PANC_MYCTU

P0A5R0

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

1n2i

1n3p

Q8GSD2_PTEAG

Q8GSD2

KO_id not found

Others

1n3p

1nb0

RIFK_HUMAN

Q969G6

K00861

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Riboflavin kinase

1nb0

1nb9

RIFK_HUMAN

Q969G6

K00861

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Riboflavin kinase

1nb9

1nc1

MTNN_ECO57

P0AF14

K01243

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

Adenosylhomocysteine nucleosidase

1nc1

1nc3

MTNN_ECO57

P0AF14

K01243

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

Adenosylhomocysteine nucleosidase

1nc3

1ndy

ADA_BOVIN

P56658

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1ndy

1ne4

KAP0_BOVIN

P00514

K04739

Others

Organismal Systems

Endocrine system

Insulin signaling pathway

PRKAR; cAMP-dependent protein kinase regulator

1ne4

1ne6

KAP0_BOVIN

P00514

K04739

Others

Organismal Systems

Endocrine system

Insulin signaling pathway

PRKAR; cAMP-dependent protein kinase regulator

1ne6

1nlu

PICP_PSESR

P42790

KO_id not found

Others

1nlu

1nmk

PPIA_HUMAN

P62937

K03767

Enzymes

Isomerases

Cis-trans-Isomerases

Cis-trans Isomerases (only sub-subclass identified to date)

Peptidylprolyl isomerase

1nmk

1nqu

RISB_AQUAE

O66529

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

1nqu

1nqv

RISB_AQUAE

O66529

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

1nqv

1nup

NMNA3_HUMAN

Q96T66

K06210

Enzymes

Transferases

Transferring phosphorus-containing groups

Nucleotidyltransferases

Nicotinamide-nucleotide adenylyltransferase

1nup

1nva

ARO1_EMENI

P07547

K13830

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Shikimate dehydrogenase

1nva

Enzymes

1nvs

1nvs-ucm-1.80-d-1-s

1784

oncolytic

serine/threonine-protein kinase Chk1 (checkpoint kinase)

EC2.- (transferases)

kinases (serine-threonine)

Chk1

cancer

prevention of cell cycle delays that provide opportunities for cells to repair DNA damage
interference with G(2)/M cell cycle control

ucm

1.80

SB-218078

O=C1NC(=O)c2c1c3c4ccccc4n5[C@H]6CC[C@H](O6)n7c8ccccc8c2c7c53

135897-06-2

cas

Structural basis for Chk1 inhibition by UCN-01

Zhao B, Bower MJ, McDevitt PJ, Zhao H, Davis ST, Johanson KO, Green SM, Concha NO, Zhou BB

J Biol Chem 277(48):46609-15

2002

10.1074/jbc.M201233200

1nwk

ACTS_RABIT

P68135

K10354

Others

Eukaryotic cytoskeleton proteins

Actin filaments - Microfilaments

Actins

1nwk

1o5o

UPP_THEMA

Q9WZI0

K00761

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uracil phosphoribosyltransferase

1o5o

1o5r

ADA_BOVIN

P56658

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1o5r

1o69

Q9S5Y7_CAMJU

Q9S5Y7

KO_id not found

Others

1o69

1o6g

PPCE_PIG

P23687

K01322

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Prolyl oligopeptidase

1o6g

1o6y

PKNB_MYCTU

P0A5S4

K08884

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

1o6y

1ocn

GUX6_HUMIN

Q9C1S9

KO_id not found

Others

1ocn

1od1

CARP_CRYPA

P11838

K01381

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Saccharopepsin

1od1

1of1

KITH_HHV11

P03176

K00857

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Thymidine kinase

1of1

Enzymes

1ogu

1ogu-st8-2.6-h-1

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

st8

2.60

610755-06-1

NC(=O)c1ccc(Nc2nc(N)c(N=O)c(OCC3CCCCC3)n2)cc1

610755-06-1

CAS

Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2

Sayle KL, Bentley J, Boyle FT, Calvert AH, Cheng Y, Curtin NJ, Endicott JA, Golding BT, Hardcastle IR, Jewsbury P, Mesguiche V, Newell DR, Noble ME, Parsons RJ, Pratt DJ, Wang LZ, Griffin RJ

Bioorg Med Chem Lett 13(18):3079-82

2003

10.1016/S0960-894X(03)00651-6

1ogu

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1ogu

Enzymes

1oi9

1oi9-n20-2.1-h-1-s

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

n20

2.10

444722-92-3

Oc1ccc(Nc2nc(OCC3CCCCC3)c4nc[nH]c4n2)cc1

444722-92-3

CAS

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

Hardcastle IR, Arris CE, Bentley J, Boyle FT, Chen Y, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Jewsbury P, Menyerol J, Mesguiche V, Newell DR, Noble ME, Pratt DJ, Wang LZ, Whitfield HJ

J Med Chem 47(15):3710-22

2004

10.1021/jm0311442

Enzymes

1oiq

1oiq-hdu-2.31-h-1-s

229

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

hdu

2.31

611239-38-4

CC(=O)Nc1nccc(n1)c2c(C)nc3ccccn23

611239-38-4

CAS

Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation

Anderson M, Beattie JF, Breault GA, Breed J, Byth KF, Culshaw JD, Ellston RP, Green S, Minshull CA, Norman RA, Pauptit RA, Stanway J, Thomas AP, Jewsbury PJ

Bioorg Med Chem Lett 13(18):3021-6

2003

10.1016/S0960-894X(03)00638-3

Enzymes

1oiu

1oiu-n76-2.00-h-1-s

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

n76

2.00

721925-82-2

NS(=O)(=O)c1cccc(Nc2nc(OCC3CCCCC3)c4nc[nH]c4n2)c1

721925-82-2

CAS

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

J Med Chem 47(15):3710-22

2004

10.1021/jm0311442

Enzymes

1oiu

1oiu-n76-2.00-h-1

430

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

n76

2.00

721925-82-2

NS(=O)(=O)c1cccc(Nc2nc(OCC3CCCCC3)c4nc[nH]c4n2)c1

721925-82-2

CAS

N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2

J Med Chem 47(15):3710-22

2004

10.1021/jm0311442

1olt

HEMN_ECOLI

P32131

K02495

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With other acceptors

Coproporphyrinogen dehydrogenase

1olt

1oq5

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1oq5

Enzymes

1os5

1os5-nh1-2.20-d-1

2889

antiinfective

RNA-dependent RNA polymerase (NS5B) from hepatitic C virus

EC2.- (transferases)

RNA polymerases

NS5B (HCV)

hepatitis C virus infection

inhibition of viral replication
inhibition of transcription of viral genomic RNA and consequently of viral genome replication

nh1

2.20

INT-239804-71-8-art-1-d

Cc1cc(SC2=C(O)C[C@](CCc3ccc(O)cc3)(OC2=O)C4CCCC4)c(cc1N)C(C)(C)C

INT-239804-71-8-art-1-d

INT

Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme

Love RA, Parge HE, Yu X, Hickey MJ, Diehl W, Gao J, Wriggers H, Ekker A, Wang L, Thomson JA, Dragovich PS, Fuhrman SA

J Virol 77(13):7575-81

2003

10.1128/JVI.77.13.7575-7581.2003

Enzymes

1osn

1osn-bvp-3.20-d-1-s

0.252736664191954

antiinfective

Varicella zoster virus thymidine kinase

EC2.- (transferases)

kinases (thymidine)

TK (V.zoster)

herpes infection

substrate of viral thymidine kinase thereby activation of prodrug
termination of viral DNA elongation at the viral DNA polymerase

bvp

3.20

brivudin monophosphate

C1=C(C(=O)NC(=O)N1[C@H]2C[C@@H]([C@H](O2)COP(=O)(O)O)O)C=CBr

80860-82-8

CAS

Crystal structure of varicella zoster virus thymidine kinase

Bird LE, Ren J, Wright A, Leslie KD, Degreve B, Balzarini J, Stammers DK

J Biol Chem 278(27):24680-7

2003

10.1074/jbc.M302025200

Enzymes

1osn

1osn-bvp-3.20-d-1

0.807177721263051

antiinfective

Varicella zoster virus thymidine kinase

EC2.- (transferases)

kinases (thymidine)

TK (V.zoster)

herpes infection

substrate of viral thymidine kinase thereby activation of prodrug
termination of viral DNA elongation at the viral DNA polymerase

bvp

3.20

brivudin monophosphate

C1=C(C(=O)NC(=O)N1[C@H]2C[C@@H]([C@H](O2)COP(=O)(O)O)O)C=CBr

80860-82-8

CAS

Crystal structure of varicella zoster virus thymidine kinase

Bird LE, Ren J, Wright A, Leslie KD, Degreve B, Balzarini J, Stammers DK

J Biol Chem 278(27):24680-7

2003

10.1074/jbc.M302025200

1oum

DEOD_ECOLI

P0ABP8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1oum

1ov6

DEOD_ECOLI

P0ABP8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1ov6

1ovg

DEOD_ECOLI

P0ABP8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1ovg

1oxl

PA2B8_DABRR

P59071

KO_id not found

Others

1oxl

1p19

Q27796_TRYCR

Q27796

KO_id not found

Others

1p19

Enzymes

1p2a

1p2a-5bn-2.5-h-1-s

0.77405

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

sbn

2.5

444099-54-1

[C=1C=C(NC1)C=2C=C(C=3C(=CC=C4C3C2C(=O)N4)F)NCCN]

444099-54-1

CAS

3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors

Liu, J.-J., Dermatakis, A., Lukacs, C.M., Konzelmann, F., Chen, Y., Kammlott, U., Depinto, W., Yang, H., Yin, X., Chen, Y., Schutt, A., Simcox, M.E., Luk, K.-C.

Bioorg Med Chem 13:2465-2468

2003

10.1016/S0960-894X(03)00488-8

Enzymes

1p2a

1p2a-5bn-2.5-h-1

6.85309

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

sbn

2.5

444099-54-1

[C=1C=C(NC1)C=2C=C(C=3C(=CC=C4C3C2C(=O)N4)F)NCCN]

444099-54-1

CAS

3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors

Liu, J.-J., Dermatakis, A., Lukacs, C.M., Konzelmann, F., Chen, Y., Kammlott, U., Depinto, W., Yang, H., Yin, X., Chen, Y., Schutt, A., Simcox, M.E., Luk, K.-C.

Bioorg Med Chem 13:2465-2468

2003

10.1016/S0960-894X(03)00488-8

Enzymes

1p2a

1p2a-5bn-2.50-h-1-s

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

5bn

2.50

444099-54-1

NCCNc1cc(c2ccc[nH]2)c3C(=O)Nc4ccc(F)c1c43

444099-54-1

CAS

3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors

Liu JJ, Dermatakis A, Lukacs C, Konzelmann F, Chen Y, Kammlott U, Depinto W, Yang H, Yin X, Chen Y, Schutt A, Simcox ME, Luk KC

Bioorg Med Chem Lett 13(15):2465-8

2003

10.1016/S0960-894X(03)00488-8

Enzymes

1p2a

1p2a-5bn-2.50-h-1

947

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

5bn

2.50

444099-54-1

NCCNc1cc(c2ccc[nH]2)c3C(=O)Nc4ccc(F)c1c43

444099-54-1

CAS

3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors

Liu JJ, Dermatakis A, Lukacs C, Konzelmann F, Chen Y, Kammlott U, Depinto W, Yang H, Yin X, Chen Y, Schutt A, Simcox ME, Luk KC

Bioorg Med Chem Lett 13(15):2465-8

2003

10.1016/S0960-894X(03)00488-8

1p33

PTR1_LEITA

P42556

KO_id not found

Enzymes

1. Oxidoreductases

pteridine reductases

PTR1 (L.tarantolae)

Others

1p33

1p91

RLMA_ECOLI

P36999

K00563

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

23S rRNA (guanine745-N1)-methyltransferase

1p91

Enzymes

1pbk

1pbk-rap-2.50-d-1

186

immunologic

25 kDa FK506 binding protein C-terminal domain peptidyl-prolyl isomerase

EC5.- (isomerases)

peptidyl-prolyl cis-trans isomerases

FKBP

autoimmune suppression

blockage of T-cell activation

rap

2.50

rapamycin

CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C(\C)/[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC)CC[C@H]1O

53123-88-9

cas

Structure of the human 25 kDa FK506 binding protein complexed with rapamycin

Liang J, Hung DT, Schreiber SL, Clardy J

Am Chem Soc 118 pp. 1231

1996

10.1021/ja953139w

1pf7

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pf7

1pj7

Q9AGP8_ARTGO

Q9AGP8

KO_id not found

Others

1pj7

1pj8

PRTK_TRIAL

P06873

KO_id not found

Others

1pj8

1pjq

CYSG_SALTY

P25924

K02302

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With NAD+ or NADP+ as acceptor

Precorrin-2 dehydrogenase

1pjq

1pk7

DEOD_ECO57

P0ABP9

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pk7

1pk9

DEOD_ECO57

P0ABP9

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pk9

1pke

DEOD_ECO57

P0ABP9

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pke

Enzymes

1ppl

1ppl-val-1.70-d-1

644

antiinfective
cardiovascular

penicillopepsin

EC3.- (hydrolases)

proteases (aspartic)

penicillopepsin

fundamental research
cardiovascular diseases

inhibition of aspartic protease proteolytic activity

val

1.70

128923-36-4

COC(=O)[C@H](Cc1ccccc1)O[P@@](=O)(O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C

128923-36-4

CAS

Crystallographic analysis of transition-state mimics bound to penicillopepsin: phosphorus-containing peptide analogues

Fraser ME, Strynadka NC, Bartlett PA, Hanson JE, James MN

Biochemistry 31(22):5201-14

1992

1ppl

PENP_PENJA

P00798

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

penicillopepsin

Others

1ppl

1pr0

DEOD_ECO57

P0ABP9

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pr0

1pr4

DEOD_ECO57

P0ABP9

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pr4

1pr5

DEOD_ECO57

P0ABP9

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pr5

1pr6

DEOD_ECO57

P0ABP9

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1pr6

1pwm

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

1pwm

1pye

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1pye

1pzg

P90613_TOXGO

P90613

KO_id not found

Others

1pzg

1q0h

DXR_ECOLI

P45568

K00099

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

1-deoxy-D-xylulose-5-phosphate reductoisomerase

1q0h

1q23

CAT_ECOLX

P62577

KO_id not found

Others

1q23

1q3a

MMP10_HUMAN

P09238

K01396

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 2

1q3a

1q3d

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

1q3d

1q3s

THSA_PYRKO

P61111

KO_id not found

Others

1q3s

1q5k

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

1q5k

1q66

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

1q66

1qcf

HCK_HUMAN

P08631

K08893

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

1qcf

1qf1

THER_BACTH

P00800

KO_id not found

Others

1qf1

1qf2

THER_BACTH

P00800

KO_id not found

Others

1qf2

Enzymes

1qhi

1qhi-bpg-1.90-d-1-s

antiinfective

Herpes simplex virus thymidine kinase

EC2.- (transferases)

kinases (thymidine)

TK (HSV1)

herpes infection

inhbition of viral thymidine kinase
prevention of viral DNA elongation

bpg

1.90

161363-19-5

OCCCCn1cnc2c(=O)nc(Nc3ccccc3)[nH]c12

161363-19-5

cas

Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir

Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR

FEBS Lett 443(2):121-5

1999

10.1016/S0014-5793(98)01619-6

Enzymes

1qhi

1qhi-bpg-1.90-d-1

752

antiinfective

herpes simplex virus thymidine kinase

EC2.- (transferases)

kinases (thymidine)

TK (HSV1)

herpes infection

phosphorylation of prodrug, inhibition of viral DNA polymerase

bpg

1.9

9-(4-Hydroxybutyl)-N2-phenylguanine

OCCCCn1cnc2c(=O)nc(Nc3ccccc3)[nH]c12

161363-19-5

cas

Structure to 1.9A Resolution of a Complex with Herpes Simplex Virus Type-I Thymidine Kinase of a Novel Non-Substrate Inhibitor: X-Ray Crystallographic Comparison with Binding of Aciclovir

Bennett, M. S., Wien, F., Champness, J. N., Batuwangala, T., Rutherford, T., Summers, W. C., Sun, H., Wright, G., Sanderson, M. R.

FEBS Lett. 443 pp. 121

1999

1qhi

KITH_HHV11

P03176

K00857

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Thymidine kinase

1qhi

1qji

ASTA_ASTFL

P07584

K00673

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Arginine N-succinyltransferase

1qji

1qjj

ASTA_ASTFL

P07584

K00673

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Arginine N-succinyltransferase

1qjj

1qk3

HGXR_TOXGO

Q26997

KO_id not found

Enzymes

2. Transferases

phosphoribosyl transferases

HGPRTase (T.gondii)

Others

1qk3

1qk4

HGXR_TOXGO

Q26997

KO_id not found

Enzymes

2. Transferases

phosphoribosyl transferases

HGPRTase (T.gondii)

Others

1qk4

1qk5

HGXR_TOXGO

Q26997

KO_id not found

Others

1qk5

1qon

ACES_DROME

P07140

K01049

Enzymes

Hydrolases

Acting on ester bonds

Carboxylic-ester hydrolases

Acetylcholinesterase

1qon

1qoq

TRPA_SALTY

P00929

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

1qoq

Enzymes

1qpc

1qpc-anp-1.60-h-1-s

125

no info

Lymphocyte-specific kinase LCK

EC2.- (transferases)

kinases (tyrosine)

Lck

autoimmune suppression

no info

anp

1.60

47542-69-8

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](=O)(O)O[P@@](=O)(N)O)[C@@H](O)[C@H]3O

47542-69-8

CAS

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Zhu X, Kim JL, Newcomb JR, Rose PE, Stover DR, Toledo LM, Zhao H, Morgenstern KA

Structure Fold Des 7(6):651-61

1999

Enzymes

1qpc

1qpc-anp-1.60-h-1

885

no info

Lymphocyte-specific kinase LCK

EC2.- (transferases)

kinases (tyrosine)

Lck

autoimmune suppression

no info

anp

1.60

47542-69-8

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](=O)(O)O[P@@](=O)(N)O)[C@@H](O)[C@H]3O

47542-69-8

CAS

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Zhu X, Kim JL, Newcomb JR, Rose PE, Stover DR, Toledo LM, Zhao H, Morgenstern KA

Structure Fold Des 7(6):651-61

1999

1qpe

LCK_HUMAN

P06239

K05856

CAM ligands

Immunoglobulin Superfamily

Immune system

CD2 family

CD48, BCM1; CD48 antigen [KO- ]

1qpe

1qsn

Q27198_TETTH

Q27198

KO_id not found

Others

1qsn

1qv0

OBL_OBELO

Q27709

KO_id not found

Others

1qv0

1qw8

ABFA_GEOSE

Q9XBQ3

K01209

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Alpha-N-arabinofuranosidase

1qw8

1qw9

ABFA_GEOSE

Q9XBQ3

K01209

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Alpha-N-arabinofuranosidase

1qw9

1qy5

ENPL_CANFA

P41148

K09487

Chaperones and folding catalysts

Heat shock proteins

HSP90

K09487 HSP90B, TRA1; heat shock protein 90kDa beta

Endoplasmic reticulum

1qy5

1qy8

ENPL_CANFA

P41148

K09487

Chaperones and folding catalysts

Heat shock proteins

HSP90

K09487 HSP90B, TRA1; heat shock protein 90kDa beta

Endoplasmic reticulum

1qy8

1qzy

AMPM2_HUMAN

P50579

K01265

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aminopeptidases

Methionyl aminopeptidase

1qzy

Enzymes

1r0p

1r0p-ksa-1.80-d-1-s

185

oncolytic

protein-tyrosine kinase (hepatocyte growth factor receptor tyrosine kinase)

EC2.- (transferases)

kinases (tyrosine)

c-Met

cancer

inhibition of enzyme activation via autophosphorylation
inhibition of cell proliferation

ksa

1.80

K-252A

COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

99533-80-9

cas

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C

Proc Natl Acad Sci U S A 100(22):12654-9

2003

10.1073/pnas.1734128100

Enzymes

1r0p

1r0p-ksa-1.80-d-1

1187

oncolytic

protein-tyrosine kinase (hepatocyte growth factor receptor tyrosine kinase)

EC2.- (transferases)

kinases (tyrosine)

c-Met

cancer

inhibition of enzyme activation via autophosphorylation
inhibition of cell proliferation

ksa

1.80

K-252A

COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

99533-80-9

cas

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C

Proc Natl Acad Sci U S A 100(22):12654-9

2003

10.1073/pnas.1734128100

Enzymes

1r0p

1r0p-ksa-1.80-d-2-s

oncolytic

protein-tyrosine kinase (hepatocyte growth factor receptor tyrosine kinase)

EC2.- (transferases)

kinases (tyrosine)

c-Met

cancer

inhibition of enzyme activation via autophosphorylation
inhibition of cell proliferation

ksa

1.80

K-252A

COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

99533-80-9

cas

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C

Proc Natl Acad Sci U S A 100(22):12654-9

2003

10.1073/pnas.1734128100

Enzymes

1r0p

1r0p-ksa-1.80-d-2

626

oncolytic

protein-tyrosine kinase (hepatocyte growth factor receptor tyrosine kinase)

EC2.- (transferases)

kinases (tyrosine)

c-Met

cancer

inhibition of enzyme activation via autophosphorylation
inhibition of cell proliferation

ksa

1.80

K-252A

COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

99533-80-9

cas

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a

Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C

Proc Natl Acad Sci U S A 100(22):12654-9

2003

10.1073/pnas.1734128100

1r0p

MET_HUMAN

P08581

K05099

Cellular antigens

Non-CD molecules

MET; met proto-oncogene (hepatocyte growth factor receptor)

Others

1r0p

Enzymes

1r78

1r78-fmd-2.00-h-1

196

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

fmd

2.00

275387-94-5

COc1cc[nH]c1/C=C/2\C(=O)Nc3ccc(F)c(C#C[C@@H](O)[C@@H](N)[C@@H](C)O)c23

275387-94-5

CAS

A new series of potent oxindole inhibitors of CDK2

Luk KC, Simcox ME, Schutt A, Rowan K, Thompson T, Chen Y, Kammlott U, DePinto W, Dunten P, Dermatakis A

Bioorg Med Chem Lett 14(4):913-7

2004

10.1016/j.bmcl.2003.12.009

1rct

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1rct

1rd4

ITAL_HUMAN

P20701

K05718

Cellular antigens

CD (clusters of differentiation) molecules

CD11a; integrin alpha L

Others

1rd4

Toxins and defence proteins

1rdp

1rdp-bv3-1.35-d-1-s

0.23117077

antiinfective

cholera toxin

Toxins

bacterial toxins

toxin (cholera)

diarrhoea

inhibition of cell receptor binding by toxin
interference with bacterial toxin entry into host cell

bv3

1.35

INT-836666-90-1-art-2-d

C=1C(=CC(=CC1[N+](=O)[O-])O[C@@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O)C(=O)N

INT-836666-90-1-art-2-d

int

Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer

Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E

Chem Biol 11(9):1205-15

2004

10.1016/j.chembiol.2004.06.008

1rev

POL_HV1H2

P04585

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1rev

Toxins and defence proteins

1rf2

1rf2-bv4-1.35-d-1-s

0.60402685

antiinfective

cholera toxin

Toxins

bacterial toxins

toxin (cholera)

diarrhoea

inhibition of cell receptor binding by toxin
interference with bacterial toxin entry into host cell

bv4

1.35

INT-836666-90-1-art-2-d

C=1C(=CC(=CC1[N+](=O)[O-])O[C@@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O)C(=O)N

INT-836666-90-1-art-2-d

int

Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer

Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E

Chem Biol 11(9):1205-15

2004

10.1016/j.chembiol.2004.06.008

Toxins and defence proteins

1rf2

1rf2-bv4-1.35-d-1

2.39970172

antiinfective

cholera toxin

Toxins

bacterial toxins

toxin (cholera)

diarrhoea

inhibition of cell receptor binding by toxin
interference with bacterial toxin entry into host cell

bv4

1.35

INT-836666-90-1-art-2-d

C=1C(=CC(=CC1[N+](=O)[O-])O[C@@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O)C(=O)N

INT-836666-90-1-art-2-d

int

Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer

Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E

Chem Biol 11(9):1205-15

2004

10.1016/j.chembiol.2004.06.008

1rfg

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1rfg

1rft

PDXK_SHEEP

P82197

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

1rft

1rfv

PDXK_SHEEP

P82197

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

1rfv

1rgs

KAP0_BOVIN

P00514

K04739

Others

Organismal Systems

Endocrine system

Insulin signaling pathway

PRKAR; cAMP-dependent protein kinase regulator

1rgs

1rjk

VDR_RAT

P13053

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

1rjk

1rkd

RBSK_ECOLI

P0A9J6

K00852

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Ribokinase

1rkd

Enzymes

1rkp

1rkp-ibm-2.05-x-1-s

3.818046234

cardiovascular

phosphodiesterase 5A

EC3.- (hydrolases)

phosphodiesterases

PDE 5A

cardiovascular diseases

inhibition of cGMP degradation

ibm

2.05

3-isobutyl-1-methylxanthine

CC(C)CN1C2=C(C(=O)N(C1=O)C)N=CN2

28822-58-4

CAS

Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity

Huai Q, Liu Y, Francis SH, Corbin JD, Ke H

J Biol Chem 279(13):13095-101

2004

10.1074/jbc.M311556200

1rmh

PPIA_CHLAE

P62938

K03767

Enzymes

Isomerases

Cis-trans-Isomerases

Cis-trans Isomerases (only sub-subclass identified to date)

Peptidylprolyl isomerase

1rmh

1ro6

PDE4B_HUMAN

Q07343

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

1ro6

1rq9

Q5RTL1_9HIV1

Q5RTL1

KO_id not found

Others

1rq9

1rrm

FUCO_ECOLI

P0A9S1

K01206

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Alpha-L-fucosidase

1rrm

1rrv

Q9AFC7_AMYOR

Q9AFC7

KO_id not found

Others

1rrv

1rsz

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1rsz

1rt1

POL_HV1H2

P04585

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1rt1

1rvv

RISB_BACSU

P11998

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

1rvv

1rxj

SAV_STRAV

P22629

KO_id not found

Others

1rxj

1ry0

AK1C3_HUMAN

P42330

K00089

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

3alpha-hydroxysteroid dehydrogenase (A-specific)

1ry0

1rzy

HINT1_RABIT

P80912

KO_id not found

Others

1rzy

1s2c

AK1C3_HUMAN

P42330

K00089

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

3alpha-hydroxysteroid dehydrogenase (A-specific)

1s2c

1s3v

DYR_HUMAN

P00374

K00287

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Dihydrofolate reductase

1s3v

1s64

FNTA_RAT

Q04631

K05955

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Protein farnesyltransferase

1s64

1s9d

ARF1_BOVIN

P84080

K07937

GTP-binding proteins

Small (Monomeric) G-proteins

Arf-Sar Family

Arf-Arl1

ARF1; ADP-ribosylation factor 1

1s9d

Enzymes

1s9j

1s9j-bbm-2.40-h-1

0.86204

oncolytic

mitogen-activated protein kinase kinase 1

EC2.- (transferases)

kinases (serine-threonine)

MEK1

anticancer

inhibition (enzyme); non-competitive

bbm

2.40

915304-20-0

[C1=CC(=C(C=C1I)F)NC=2C(=CC(=C(C2F)F)Br)C(=O)NOC[C@H](CO)O]

915304-20-0

CAS

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA

Nat Struct Mol Biol 11(12):1192-7

2004

10.1038/nsmb859

1s9p

ERR3_MOUSE

P62509

K01689

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Phosphopyruvate hydratase

1s9p

1sb1

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

1sb1

1sbr

YKOF_BACSU

O34911

KO_id not found

Others

1sbr

1sd1

MTAP_HUMAN

Q13126

K00772

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

S-methyl-5'-thioadenosine phosphorylase

1sd1

1sd2

MTAP_HUMAN

Q13126

K00772

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

S-methyl-5'-thioadenosine phosphorylase

1sd2

1sjw

Q9RN59_STRNO

Q9RN59

KO_id not found

Others

1sjw

1srg

SAV_STRAV

P22629

KO_id not found

Other proteins

Bacterial proteins

binding proteins

streptavidin

Others

1srg

1895

1srj

SAV_STRAV

P22629

KO_id not found

Others

1srj

1sua

SUBT_BACAM

P00782

K01342

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Subtilisin

1sua

Other proteins

1swn

1swn-btn-2.20-d-1

antiinfective

streptavidin

Bacterial proteins

binding proteins

streptavidin

fundamental research

stabilisation of streptavidin
tool for universal test systems in immunology and molecular diagnostics
system for analysis of intermolecular interactions of the tight binding of the small molecule ligand biotin to the protein

btn

2.20

biotin

OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12

58-85-5

CAS

Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex

Freitag S, Le Trong I, Chilkoti A, Klumb LA, Stayton PS, Stenkamp RE

J Mol Biol 279(1):211-21

1998

10.1006/jmbi.1998.1735

1sx3

CH60_ECOLI

P0A6F5

K04077

Chaperones and folding catalysts

Heat shock proteins

HSP60 - Chaperonin

GroEL, HSPD1; chaperonin GroELMitochondria

Others

1sx3

1szm

KAPCA_BOVIN

P00517

K04345

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

CAMP-dependent protein kinase

1szm

1t2w

Q9S446_STAAU

Q9S446

KO_id not found

Others

1t2w

1t47

HPPD_STRAW

Q53586

K00457

Enzymes

Oxidoreductases

Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2

With incorporation of two atoms of oxygen

4-hydroxyphenylpyruvate dioxygenase

1t47

1t57

O27711_METTH

O27711

KO_id not found

Others

1t57

1t5b

AZOR_SALTY

P63462

KO_id not found

Others

1t5b

1t64

HDAC8_HUMAN

Q9BY41

K11405

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Histone deacetylase

1t64

1t7j

POL_HV1Y2

P35963

KO_id not found

Others

1t7j

1tbb

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

1tbb

1tbf

PDE5A_HUMAN

O76074

K13762

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-GMP phosphodiesterase

1tbf

1tez

PHR_SYNP6

P05327

K01669

Enzymes

Lyases

Carbon-carbon lyases

Other carbon-carbon lyases

Deoxyribodipyrimidine photo-lyase

1tez

1tgv

UDP_ECOLI

P12758

K00757

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uridine phosphorylase

1tgv

1th8

SP2AB_GEOSE

O32727

K06379

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

1th8

1tjp

TRPA_SALTY

P00929

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

1tjp

1tkx

POL_HV1H2

P04585

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1tkx

1tl1

POL_HV1H2

P04585

KO_id not found

Enzymes

2. Transferases

reverse transcriptases

RT (HIV-1)

Others

1tl1

1tou

FABP4_HUMAN

P15090

KO_id not found

Others

1tou

1tqf

BACE1_HUMAN

P56817

K04521

Peptidases

Aspartic Peptidase

Family A1 pepsin family

Beta-secretase 1

Others

1tqf

9606

1tu6

CATK_HUMAN

P43235

K01371

Chaperones and folding catalysts

Intramolecular chaperones

Papain family

CTSK; cathepsin K

Others

1tu6

1tvo

MK01_HUMAN

P28482

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1tvo

1ty8

YMX7_YEAST

Q04299

KO_id not found

Others

1ty8

1u1c

UDP_ECOLI

P12758

K00757

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uridine phosphorylase

1u1c

1u1d

UDP_ECOLI

P12758

K00757

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uridine phosphorylase

1u1d

1u1f

UDP_ECOLI

P12758

K00757

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uridine phosphorylase

1u1f

1u1g

UDP_ECOLI

P12758

K00757

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uridine phosphorylase

1u1g

1u3r

ESR2_HUMAN

Q92731

K08551

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A2, ESR2; estrogen receptor beta

Others

1u3r

1u59

ZAP70_HUMAN

P43403

K07360

Cellular antigens

Non-CD molecules

ZAP70; zeta-chain (TCR) associated protein kinase 70kDa

Others

1u59

1u71

DYR_HUMAN

P00374

K00287

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Dihydrofolate reductase

1u71

1u9z

KPRS_METJA

Q58761

K00948

Enzymes

Transferases

Transferring phosphorus-containing groups

Diphosphotransferases

Ribose-phosphate diphosphokinase

1u9z

Enzymes

1udu

1udu-cia-2.80-x-1-s

1.285607755

cardiovascular

phosphodiesterase 5A

EC3.- (hydrolases)

phosphodiesterases

PDE 5A

cardiovascular diseases

inhibition of cGMP degradation

cia

2.80

tadalafil

CN1CC(=O)N2[C@@H](C1=O)CC=3C4=CC=CC=C4NC3[C@H]2C5=CC=C6C(=C5)OCO6

171596-29-5

CAS

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

Sung BJ, Hwang KY, Jeon YH, Lee JI, Heo YS, Kim JH, Moon J, Yoon JM, Hyun YL, Kim E, Eum SJ, Park SY, Lee JO, Lee TG, Ro S, Cho JM

Nature 425(6953):98-102

2003

10.1038/nature01914

1uio

ADA_MOUSE

P03958

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1uio

Enzymes

1ung

1ung-alh-2.30-h-1

1.92692

oncolytic
neurological

cdk5
cell division kinase 5
pssalre
cyclin-dependent kinase 5
pdpk
proline-directed protein kinase 33kDa subunit
Proline-directed protein kinase F(A)
serine/threonine protein kinase pssalre
tpk II catalytic subunit
tau protein kinase II catalytic subunit

EC2.- (transferases)

kinases (serine-threonine)

CDK5

cognitive defects
cancer

inhibition (enzyme); competitive

alh

2.30

496864-16-5

[CCCCC=1C2=C(NC1C3=CC=C(C=C3)O)N=CC=N2]

496864-16-5

CAS

Mechanism of CDK5/p25 binding by CDK inhibitors

Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A

J Med Chem 48(3):671-9

2005

10.1021/jm049323m

1uoo

PPCE_PIG

P23687

K01322

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Prolyl oligopeptidase

1uoo

1uop

PPCE_PIG

P23687

K01322

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Prolyl oligopeptidase

1uop

1uoq

PPCE_PIG

P23687

K01322

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Prolyl oligopeptidase

1uoq

Enzymes

1upf

1upf-urf-2.30-d-1

1043

antiinfective

parasitic uracil phosphoribosyltransferase (from Toxoplasma gondii)

EC2.- (transferases)

phosphoribosyl transferases

UPRTase (T.gondii)

parasitic infection

interference with parasitic pyrimidine salvage pathway
inhibition of transfer of a ribosyl phosphate group from alpha-D-5-phosphoribosyl-1-pyrophosphate to the N1 nitrogen of uracil to form uridine monophosphate

urf

2.30

5-fluorouracil

FC1=CNC(=O)NC1=O

51-21-8

CAS

Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding

Schumacher MA, Carter D, Scott DM, Roos DS, Ullman B, Brennan RG

EMBO J 17(12):3219-32

1998

10.1093/emboj/17.12.3219

Enzymes

1ur8

1ur8-nag-1.90-d-1-s

antiinfective

Serratia marcescens chitinase

EC3.- (hydrolases)

glycosidases

chitinase (S.marcescens)

bacterial infection

inhibition of bacterial chitinase

nag

1.90

80019-02-9

CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](NC(=O)C)C(=O)O[C@@H]2CO

80019-02-9

CAS

Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono-delta-lactone

Vaaje-Kolstad G, Vasella A, Peter MG, Netter C, Houston DR, Westereng B, Synstad B, Eijsink VG, van Aalten DM

J Biol Chem 279(5):3612-9

2004

10.1074/jbc.M310057200

Enzymes

1ur8

1ur8-nag-1.90-d-1

antiinfective

Serratia marcescens chitinase

EC3.- (hydrolases)

glycosidases

chitinase (S.marcescens)

bacterial infection

inhibition of bacterial chitinase

nag

1.90

80019-02-9

CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](NC(=O)C)C(=O)O[C@@H]2CO

80019-02-9

CAS

Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono-delta-lactone

Vaaje-Kolstad G, Vasella A, Peter MG, Netter C, Houston DR, Westereng B, Synstad B, Eijsink VG, van Aalten DM

J Biol Chem 279(5):3612-9

2004

10.1074/jbc.M310057200

Enzymes

1urw

1urw-i1p-1.60-h-1

10.45488

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

i1p

1.60

453547-81-4

[CN(C)CCCNS(=O)(=O)C1=CC=C(C=C1)NC=2N=CC=C(N2)C3=CN=C4N3N=CC=C4]

453547-81-4

CAS

Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors

Byth, K.F., Cooper, N., Culshaw, J.D., Heaton, D.W., Oakes, S.E., Minshull, C.A., Norman, R.A., Pauptit, R.A., Tucker, J.A., Breed, J., Pannifer, A., Rowsell, S., Stanway, J.J., Valentine, A.L., Thomas, A.P.

Bioorg Med Chem Lett 14:2249-2252

2004

10.1016/j.bmcl.2004.02.008

1usn

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

1usn

1uu3

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

1uu3

1uu7

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

1uu7

Enzymes

1uu9

1uu9-bi3-1.95-h-1-s

oncolytic

pdk1
3-phosphoinositide-dependent kinase 1
hPDK1

EC2.- (transferases)

kinases (serine-threonine)

PDK1

cancer
diabetes

no info

bi3

1.95

bisindolylmaleimide III

NCCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15

137592-43-9

CAS

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

Komander D, Kular GS, Schuttelkopf AW, Deak M, Prakash KR, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, van Aalten DM

Structure (Camb) 12(2):215-26

2004

Enzymes

1uu9

1uu9-bi3-1.95-h-1

269

oncolytic

pdk1
3-phosphoinositide-dependent kinase 1
hPDK1

EC2.- (transferases)

kinases (serine-threonine)

PDK1

cancer
diabetes

no info

bi3

1.95

bisindolylmaleimide III

NCCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15

137592-43-9

CAS

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

Komander D, Kular GS, Schuttelkopf AW, Deak M, Prakash KR, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, van Aalten DM

Structure (Camb) 12(2):215-26

2004

Enzymes

1v1j

1v1j-fa3-2.20-d-1

0.80536913

antiinfective

bacterial 3-dehydroquinate dehydratase

EC4.- (lyases)

hydro-lyases

type II DHQase (S.coelicolor)

bacterial infection

inhibition of bacterial 3-dehydroquinate dehydratase
interference with biosynthetic shikimate pathway
interference with biosynthesis of aromatic compounds

fa3

2.20

486430-83-5

O=C(O)[C@]1(O)C=C(F)[C@@H](O)[C@H](O)C1

486430-83-5

cas

(1R,4S,5R)-3-Fluoro-1,4,5-Trihydroxy-2-Cyclohexene-1-Carboxylic Acid: The Fluoro Analogue of the Enolate Intermediate in the Reaction Catalyzed by Type II Dehydroquinases

Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C

Org Biomol Chem 2(11):1592-6

2004

10.1039/b404535a

1v1k

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1v1k

1v45

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1v45

1v79

ADA_BOVIN

P56658

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1v79

1v7a

ADA_BOVIN

P56658

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1v7a

1v9t

PPIA_ECO57

P0AFL5

K03767

Enzymes

Isomerases

Cis-trans-Isomerases

Cis-trans Isomerases (only sub-subclass identified to date)

Peptidylprolyl isomerase

1v9t

1vbt

PPIA_CHLAE

P62938

K03767

Enzymes

Isomerases

Cis-trans-Isomerases

Cis-trans Isomerases (only sub-subclass identified to date)

Peptidylprolyl isomerase

1vbt

1vhw

DEOD1_VIBCH

Q9KPM0

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1vhw

1vwe

SAV_STRAV

P22629

KO_id not found

Others

1vwe

Enzymes

1vyz

1vyz-n5b-2.21-d-1

2772

oncolytic

cyclin-dependent kinase 2
CDK2

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer

inhibition of cell cycle controlling enzyme CDK2
apoptosis in tumour cells

n5b

2.21

326822-81-5

O=C(Nc1cc([nH]n1)C2CC2)c3ccccc3

326822-81-5

cas

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding

Pevarello P, Brasca MG, Amici R, Orsini P, Traquandi G, Corti L, Piutti C, Sansonna P, Villa M, Pierce BS, Pulici M, Giordano P, Martina K, Fritzen EL, Nugent RA, Casale E, Cameron A, Ciomei M, Roletto F, Isacchi A, Fogliatto G, Pesenti E, Pastori W, Marsiglio A, Leach KL, Clare PM, Fiorentini F, Varasi M, Vulpetti A, Warpehoski MA

J Med Chem 47(13):3367-80

2004

10.1021/jm031145u

Enzymes

1w0c

1w0c-taq-2.60-d-1

0.285908351367147

antiinfective

leishmania major pteridine reductase

EC1.- (oxydo-reductases)

pteridine reductases

PTR1 (L.major)

parasitic infection

inhibition of parasitic pteridine reductase
salvage of pterins

taq

2.60

NSC 158574

C1=CC=2C(C=C1N)=C(N=C(N2)N)N

13741-90-7

CAS

Inhibition of Leishmania major pteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex

McLuskey K, Gibellini F, Carvalho P, Avery MA, W. N. Hunter WN

Acta Cryst D60, 1780-1785

2004

10.1107/S0907444904018955

1w0h

ERI1_HUMAN

Q8IV48

KO_id not found

Others

1w0h

Enzymes

1w0x

1w0x-olo-2.20-h-1-s

1628

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

olo

2.20

Olomoucine

Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

101622-51-9

CAS

Crystals Structure of Human Cdk2 in Complex with the Inhibitor Olomoucine

Schulze-Gahmen U, Meijer L, Kim SH

to be published

2005

1w0x

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1w0x

Enzymes

1w1y

1w1y-typ-1.90-d-1

1365

antiinfective

Serratia marcescens chitinase

EC3.- (hydrolases)

glycosidases

chitinase (S.marcescens)

bacterial infection

inhibition of bacterial chitinase

typ

1.90

maculosin

Oc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCN3C2=O)cc1

4549-02-4

CAS

Structure-based exploration of cyclic dipeptide chitinase inhibitors

Houston DR, Synstad B, Eijsink VG, Stark MJ, Eggleston IM, van Aalten DM

J Med Chem 47(23):5713-20

2004

10.1021/jm049940a

1w2h

KTHY_MYCTU

O05891

K00943

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with a phosphate group as acceptor

DTMP kinase

1w2h

1w82

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1w82

1w96

ACAC_YEAST

Q00955

K11262

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

1w96

1w9q

SDCB1_HUMAN

O00560

KO_id not found

Others

1w9q

Enzymes

1w9u

1w9u-rig-1.85-d-1

1917

antiinfective

aspergillus fumigatus chitinase

EC3.- (hydrolases)

glycosidases

ChiB1 (A.fumigatus)

fungal infection

inhibition of fungal chitinase
interference with cell wall

rig

1.85

argadin

CC(=O)NC(=N)NCCC[C@@H]1NC(=O)[C@H](CCCC(=O)O)NC(=O)[C@H](Cc2cnc[nH]2)N3[C@H](O)C[C@H](NC(=O)[C@H]4CCCN4C1=O)C3=O

289665-92-5

cas

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases

Rao FV, Houston DR, Boot RG, Aerts JM, Hodkinson M, Adams DJ, Shiomi K, Omura S, van Aalten DM

Chem Biol 12(1):65-76

2005

10.1016/j.chembiol.2004.10.013

1w9v

Q873X9_ASPFM

Q873X9

KO_id not found

Enzymes

3. Hydrolases

glycosidases

ChiB1 (A.fumigatus)

Others

1w9v

1wb0

CHIT1_HUMAN

Q13231

K01183

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Chitinase

1wb0

1wbs

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1wbs

1wbv

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1wbv

1wbw

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1wbw

1wdk

FADB_PSEFR

P28793

K13767

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Enoyl-CoA hydratase

1wdk

1wl4

THIC_HUMAN

Q9BWD1

K00626

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Acetyl-CoA C-acetyltransferase

1wl4

1wok

PARP1_HUMAN

P09874

K10798

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

1wok

Enzymes

1wrr

1wrr-unc-1.60-d-1

2146

antiinfective

aspergillus flavus urate oxidase

EC1.- (oxydo-reductases)

urate oxidases

Uox (A.flavus)

fungal infection

inhibition of fungal urate oxidase
interference with purine degradation

unc

1.60

INT-NSC 99321-art-1-d

NC1=C(NC(=O)NC1=O)N(=O)=O

INT-NSC 99321-art-1-d

int

Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site

Retailleau P, Colloc'h N, Vivares D, Bonnete F, Castro B, El Hajji M, Prange T

Acta Crystallogr D Biol Crystallogr 61(Pt 3):218-29

2005

10.1107/S0907444904031531

1ws1

DEF1_BACCR

Q819U0

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

1ws1

1wsv

GCST_HUMAN

P48728

K00605

Enzymes

Transferases

Transferring one-carbon groups

Hydroxymethyl-, formyl- and related transferases

Aminomethyltransferase

1wsv

1wxj

TRPA_THET2

P16608

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

1wxj

1wxz

ADA_BOVIN

P56658

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

1wxz

1wzy

MK01_HUMAN

P28482

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

1wzy

1x8b

WEE1_HUMAN

P30291

K06632

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

1x8b

1x97

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

1x97

1xan

GSHR_HUMAN

P00390

K00383

Enzymes

Oxidoreductases

Acting on a sulfur group of donors

With NAD+ or NADP+ as acceptor

Glutathione-disulfide reductase

1xan

1xbc

KSYK_HUMAN

P43405

K05855

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

1xbc

1xgi

AMPC_ECOLI

P00811

K01467

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amides

Beta-lactamase

1xgi

1xjj

O33839_THEMT

O33839

K00525

Enzymes

Oxidoreductases

Acting on CH or CH2 groups

With a disulfide as acceptor

Ribonucleoside-diphosphate reductase

1xjj

1xlx

PDE4B_HUMAN

Q07343

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

1xlx

1xnn

ANDR_RAT

P15207

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

1xnn

Enzymes

1xo2

1xo2-fse-2.90-h-1

0.18941

oncolytic

plstire
cdk6
cyclin-dependent kinase 6
serine/theronine protein kinase plstire

EC2.- (transferases)

kinases (serine-threonine)

CDK6

cancer

inhibition (enzyme); competitive

fse

2.90

Fisetin (6CI)

[C=1C=C(C(=CC1C2=C(C(=O)C3=CC=C(C=C3O2)O)O)O)O]

528-48-3

CAS

Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin

Lu, H.S., Chang, D.J., Baratte, B., Meijer, L., Schulze-Gahmen, U.

J Med Chem 48: 737-747

2005

10.1021/jm049353p S0022-2623(04)09353-7

1xo2

CGH2_SHV21

Q01043

KO_id not found

Enzymes

2. Transferases

kinases (serine-threonine)

CDK6

Others

1xo2

1xom

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

1xom

1xoq

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

1xoq

1xor

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

1xor

1xow

ANDR_HUMAN

P10275

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

1xow

Enzymes

1xoz

1xoz-cia-1.37-x-1-s

0.155108128

cardiovascular

phosphodiesterase 5A

EC3.- (hydrolases)

phosphodiesterases

PDE 5A

cardiovascular diseases

inhibition of cGMP degradation

cia

1.37

tadalafil

CN1CC(=O)N2[C@@H](C1=O)CC=3C4=CC=CC=C4NC3[C@H]2C5=CC=C6C(=C5)OCO6

171596-29-5

CAS

Structural basis for the activity of drugs that inhibit phosphodiesterases

Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY

Structure 12(12):2233-47

2004

10.1016/j.str.2004.10.004

Enzymes

1xoz

1xoz-cia-1.37-x-1

4.298284862

cardiovascular

phosphodiesterase 5A

EC3.- (hydrolases)

phosphodiesterases

PDE 5A

cardiovascular diseases

inhibition of cGMP degradation

cia

1.37

tadalafil

CN1CC(=O)N2[C@@H](C1=O)CC=3C4=CC=CC=C4NC3[C@H]2C5=CC=C6C(=C5)OCO6

171596-29-5

CAS

Structural basis for the activity of drugs that inhibit phosphodiesterases

Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY

Structure 12(12):2233-47

2004

10.1016/j.str.2004.10.004

1xpz

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1xpz

1xq0

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

1xq0

1xqp

AGOG_PYRAE

Q8ZVK6

K01741

Enzymes

Lyases

Carbon-oxygen lyases

Other carbon-oxygen lyases

DNA-(apurinic or apyrimidinic site) lyase

1xqp

1xwf

SAHH_RAT

P10760

K01251

Enzymes

Hydrolases

Acting on ether bonds

Thioether and trialkylsulfonium hydrolases

Adenosylhomocysteinase

1xwf

1y2e

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

1y2e

1y5v

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

1y5v

1y8j

NEP_HUMAN

P08473

K01389

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neprilysin

1y8j

Enzymes

1y8y

1y8y-ct7-2.00-h-1

8.64877

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

ct7

2.00

771498-73-8

[CS(=O)(=O)C1=CC=C(C=C1)NC2=CC(=NC=3N2N=CC3)Cl]

771498-73-8

CAS

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2

Williamson, D.S., Parratt, M.J., Bower, J.F., Moore, J.D., Richardson, C.M., Dokurno, P., Cansfield, A.D., Francis, G.L., Hebdon, R.J., Howes, R., Jackson, P.S., Lockie, A.M., Murray, J.B., Nunns, C.L., Powles, J., Robertson, A., Surgenor, A.E., Torrance, C.J.

Bioorg Med Chem Lett 15:863-867

2005

10.1016/j.bmcl.2004.12.073

1y8y

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1y8y

Enzymes

1y91

1y91-ct9-2.15-h-1

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

modulation of cell division, inhibition of signal transduction pathways

ct9

2.15

771499-44-6

CS(=O)(=O)c1ccc(Nc2cc(Cl)nc3ccnn23)cc1

771499-44-6

CAS

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2

Williamson DS, Parratt MJ, Bower JF, Moore JD, Richardson CM, Dokurno P, Cansfield AD, Francis GL, Hebdon RJ, Howes R, Jackson PS, Lockie AM, Murray JB, Nunns CL, Powles J, Robertson A, Surgenor AE, Torrance CJ

Bioorg Med Chem Lett 15(4):863-7

2005

10.1016/j.bmcl.2004.12.073

1ygk

PDXK_SHEEP

P82197

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

1ygk

1yhj

PDXK_SHEEP

P82197

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

1yhj

1ykd

P94182_9NOST

P94182

KO_id not found

Others

1ykd

1ykr

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

1ykr

1yp4

GLGS_SOLTU

P23509

K00975

Enzymes

Transferases

Transferring phosphorus-containing groups

Nucleotidyltransferases

Glucose-1-phosphate adenylyltransferase

1yp4

1yry

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

1yry

1ysz

ENPL_CANFA

P41148

K09487

Chaperones and folding catalysts

Heat shock proteins

HSP90

K09487 HSP90B, TRA1; heat shock protein 90kDa beta

Endoplasmic reticulum

1ysz

1yt7

CATK_HUMAN

P43235

K01371

Chaperones and folding catalysts

Intramolecular chaperones

Papain family

CTSK; cathepsin K

Others

1yt7

1z1h

POL_HV1A2

P03369

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1z1h

1z1r

POL_HV1A2

P03369

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

1z1r

Enzymes

1z4r

1z4r-aco-1.74-t-2

2445

oncolytic

general control of amino acid synthesis protein 5-like 2 (histone acetyltransferase GCN5L2)

EC2.- (transferases)

acyltransferases

GCN5

cancer

GCN5L2 inhibition influences transcription and is suggested to moderate other DNA-based mechanisms as well (e.g. cell-cycle progression, DNA recombination, DNA repair, and apoptosis).

aco

1.74

acetyl coenzyme A

CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO[P@@](=O)(O)O[P@@](=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)OP(=O)(O)O)O

72-89-9

cas

Crystal Structure of Human Acetyltransferase GCN5

Bernstein G, Dong A, Schuetz A, Antoshenko T, Wu H, Loppnau P, Bochkarev A, Plotnikov A

to be published

2006

Enzymes

1z5m

1z5m-li8-2.17-h-1

oncolytic

pdk1
3-phosphoinositide-dependent kinase 1
hPDK1

EC2.- (transferases)

kinases (serine-threonine)

PDK1

cancer
diabetes

no info

li8

2.17

CC(C)(C(=O)N)C(=O)N/C=C\CNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br

CAS

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1

Feldman RI, Wu JM, Polokoff MA, Kochanny MJ, Dinter H, Zhu D, Biroc SL, Alicke B, Bryant J, Yuan S, Buckman BO, Lentz D, Ferrer M, Whitlow M, Adler M, Finster S, Chang Z, Arnaiz DO

J Biol Chem 280(20):19867-74

2005

10.1074/jbc.M501367200

1z5m

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

1z5m

1z5o

MTNN_ECO57

P0AF14

K01243

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

Adenosylhomocysteine nucleosidase

1z5o

1z7y

CYSK1_ARATH

P47998

K01738

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Cysteine synthase

1z7y

1zaf

ESR2_HUMAN

Q92731

K08551

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A2, ESR2; estrogen receptor beta

Others

1zaf

1zd4

HYES_HUMAN

P34913

K08726

Enzymes

Hydrolases

Acting on ether bonds

Ether hydrolases

Soluble epoxide hydrolase

1zd4

1zdp

THER_BACTH

P00800

KO_id not found

Others

1zdp

1zfj

IMDH_STRPY

P0C0H6

K00088

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

IMP dehydrogenase

1zfj

1zgi

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

1zgi

1zgs

LEC_PARPC

P83304

KO_id not found

Others

1zgs

1zht

KES1_YEAST

P35844

KO_id not found

Others

1zht

1zkk

SETD8_HUMAN

Q9NQR1

K11428

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Histone-lysine N-methyltransferase

1zkk

1zp5

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

1zp5

1zxc

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

1zxc

2a3i

MCR_HUMAN

P08235

K08555

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C2, MR; mineralocorticoid receptor

Others

2a3i

2a58

RIB4_SCHPO

Q9UUB1

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

2a58

2a59

RIB4_SCHPO

Q9UUB1

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

2a59

2a7x

PANC_MYCTU

P0A5R0

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

2a7x

2a94

LDH_PLAFD

Q27743

K00016

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

L-lactate dehydrogenase

2a94

2aa3

Q4PRK9_PLAVI

Q4PRK9

KO_id not found

Others

2aa3

2aax

MCR_HUMAN

P08235

K08555

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C2, MR; mineralocorticoid receptor

Others

2aax

2ab2

MCR_HUMAN

P08235

K08555

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C2, MR; mineralocorticoid receptor

Others

2ab2

Enzymes

2aia

2aia-sb8-1.70-d-1-s

0.29977629

antiinfective

bacterial peptide deformylase

EC3.- (hydrolases)

amidases

PDF (S.pneumoniae)

bacterial infection

interference with bacterial protein maturation

sb8

1.70

SB-543668

C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2)OCCN(C=O)O

372951-18-3

cas

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

Smith KJ, Petit CM, Aubart K, Smyth M, McManus E, Jones J, Fosberry A, Lewis C, Lonetto M, Christensen SB

Protein Sci 12(2):349-60

2003

10.1110/ps.0229303

Enzymes

2aia

2aia-sb8-1.70-d-1

1.47651007

antiinfective

bacterial peptide deformylase

EC3.- (hydrolases)

amidases

PDF (S.pneumoniae)

bacterial infection

interference with bacterial protein maturation

sb8

1.70

SB-543668

C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2)OCCN(C=O)O

372951-18-3

cas

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species

Smith KJ, Petit CM, Aubart K, Smyth M, McManus E, Jones J, Fosberry A, Lewis C, Lonetto M, Christensen SB

Protein Sci 12(2):349-60

2003

10.1110/ps.0229303

2aia

DEF_STRR6

Q8DP79

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

2aia

2aio

BLA1_STEMA

P52700

K06479 (inferred by homologyHUMAN)

CAM ligands

1. Immunoglobulin Superfamily

Immune system

CD2 family

Metallo-beta-lactamase L1

2aio

40324

2ax6

ANDR_HUMAN

P10275

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

2ax6

2ax9

ANDR_HUMAN

P10275

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

2ax9

2axr

Q6PW77_ACRST

Q6PW77

KO_id not found

Others

2axr

2bb3

O29536_ARCFU

O29536

K03399

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Precorrin-6Y C5,15-methyltransferase (decarboxylating)

2bb3

2bfq

Y1521_ARCFU

O28751

KO_id not found

Others

2bfq

2bfr

Y1521_ARCFU

O28751

KO_id not found

Others

2bfr

2bfy

AUKBA_XENLA

Q6DE08

K11479

Chromosome

Eukaryotic Type

Centromeric chromatin formation proteins

Kinetochore proteins

Serine-threonine-protein kinase 12-A

2bfy

8355

2bgd

PTN1_HUMAN

P18031

K05696

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-monoester hydrolases

Protein-tyrosine-phosphatase

2bgd

Enzymes

2bhh

2bhh-ryu-2.60-h-1-s

0.17151

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

ryu

2.60

860817-52-3

[C[C@@]1(C2=CC=CC=C2NC1=C3C=4C=C(C=CC4NC3=O)S(=O)(=O)N5CCC(CC5)O)O]

860817-52-3

CAS

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

Jautelat, R., Brumby, T., Schafer, M., Briem, H., Eisenbrand, G., Schwahn, S., Kruger, M., Lucking, U., Prien, O., Siemeister, G.

Chembiochem 6:531-540

2005

10.1002/cbic.200400108

Enzymes

2bhh

2bhh-ryu-2.60-h-1

2.43102

oncolytic

cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase

EC2.- (transferases)

kinases (serine-threonine)

CDK2

cancer
cardiovascular diseases
viral infection

inhibition (enzyme); competitive

ryu

2.60

860817-52-3

[C[C@@]1(C2=CC=CC=C2NC1=C3C=4C=C(C=CC4NC3=O)S(=O)(=O)N5CCC(CC5)O)O]

860817-52-3

CAS

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

Jautelat, R., Brumby, T., Schafer, M., Briem, H., Eisenbrand, G., Schwahn, S., Kruger, M., Lucking, U., Prien, O., Siemeister, G.

Chembiochem 6:531-540

2005

10.1002/cbic.200400108

2ble

GMPR1_HUMAN

P36959

K00364

Enzymes

Oxidoreductases

Acting on other nitrogenous compounds as donors

With NAD+ or NADP+ as acceptor

GMP reductase

2ble

2bmc

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2bmc

2boh

FA10_HUMAN

P00742

K01314

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F10; coagulation factor X

Others

2boh

2bpm

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2bpm

2bqv

O92139_9HIV1

O92139

KO_id not found

Others

2bqv

Enzymes

2br1

2br1-pfp-2.00-h-1-s

413

no info

serin-threonin kinase

EC2.- (transferases)

kinases (serine-threonine)

Chk1

cancer

no info

pfp

2.00

378775-98-5

COc1ccc(cc1)c2oc3ncnc(NCCO)c3c2c4ccc(OC)cc4

378775-98-5

CAS

Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity

Foloppe N, Fisher LM, Howes R, Kierstan P, Potter A, Robertson AG, Surgenor AE

J Med Chem 48(13):4332-45

2005

10.1021/jm049022c

2br1

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2br1

2brb

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2brb

2brm

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2brm

Enzymes

2brn

2brn-df1-2.80-h-1-s

620

no info

serin-threonin kinase

EC2.- (transferases)

kinases (serine-threonine)

Chk1

cancer

no info

df1

2.80

859501-29-4

C[C@@H](O)CNc1ncnc2[nH]c(c(c3ccccc3)c12)c4ccccc4

859501-29-4

CAS

Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity

Foloppe N, Fisher LM, Howes R, Kierstan P, Potter A, Robertson AG, Surgenor AE

J Med Chem 48(13):4332-45

2005

10.1021/jm049022c

2brn

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2brn

Enzymes

2bro

2bro-df2-2.20-h-1-s

390

no info

serin-threonin kinase

EC2.- (transferases)

kinases (serine-threonine)

Chk1

cancer

no info

df2

2.20

859501-30-7

OC[C@H](O)CNc1ncnc2[nH]c(c(c3ccccc3)c12)c4ccccc4

859501-30-7

CAS

Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity

Foloppe N, Fisher LM, Howes R, Kierstan P, Potter A, Robertson AG, Surgenor AE

J Med Chem 48(13):4332-45

2005

10.1021/jm049022c

2bro

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2bro

2bsx

Q8T9Z7_PLAFA

Q8T9Z7

KO_id not found

Others

2bsx

2btr

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2btr

2bts

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2bts

Enzymes

2c57

2c57-fa1-3.10-d-1

0.03281133

antiinfective

bacterial 3-dehydroquinate dehydratase

EC4.- (lyases)

hydro-lyases

type II DHQase (H.pylori)

gastric ulcer
bacterial infection

inhibition of bacterial 3-dehydroquinate dehydratase
interference with biosynthetic shikimate pathway
interference with biosynthesis of aromatic compounds

fa1

3.10

227002-11-1

O=C(O)[C@]1(O)C=C[C@@H](O)[C@H](O)C1

227002-11-1

cas

Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design

Robinson DA, Stewart KA, Price NC, Chalk PA, Coggins JR, Lapthorn AJ

J Med Chem 49(4):1282-90

2006

10.1021/jm0505361

2c5x

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2c5x

2c69

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2c69

2c6i

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2c6i

2c6m

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2c6m

2c9b

RISB_MYCTU

P66034

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

2c9b

2cgw

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2cgw

Enzymes

2cnf

2cnf-f32-2.20-d-1-s

0.01789709

endocrine

protein tyrosine phosphatase 1B

EC3.- (hydrolases)

phosphatases

PTP 1B

diabetes
obesity

dephosphorylation of insulin receptor and insulin receptor substrate tyrosine residues
prevention of insulin resistance

f32

2.20

850326-88-4

C1=CC=C2C(=C1)NC(=N2)[C@H](CC3=CC=C(C=C3)[C@@H]4CC(=O)NS4(=O)=O)NC5=NC6=CC=CC=C6S5

850326-88-4

cas

Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein Tyrosine Phosphatase 1B

Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B, Polam P, Crawley ML, Mclaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP, Burn TC, Hollis GF, Wynn R

to be published

2006

Enzymes

2cnf

2cnf-f32-2.20-d-1

0.06860552

endocrine

protein tyrosine phosphatase 1B

EC3.- (hydrolases)

phosphatases

PTP 1B

diabetes
obesity

dephosphorylation of insulin receptor and insulin receptor substrate tyrosine residues
prevention of insulin resistance

f32

2.20

850326-88-4

C1=CC=C2C(=C1)NC(=N2)[C@H](CC3=CC=C(C=C3)[C@@H]4CC(=O)NS4(=O)=O)NC5=NC6=CC=CC=C6S5

850326-88-4

cas

Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein Tyrosine Phosphatase 1B

Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B, Polam P, Crawley ML, Mclaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP, Burn TC, Hollis GF, Wynn R

to be published

2006

Enzymes

2cni

2cni-izf-2.00-d-1-s

0.03579418

endocrine

protein tyrosine phosphatase 1B

EC3.- (hydrolases)

phosphatases

PTP 1B

diabetes
obesity

dephosphorylation of insulin receptor and insulin receptor substrate tyrosine residues
prevention of insulin resistance

izf

2.00

INT-850318-08-0-art-1-d

COC(=O)C=1C(=CC=CC1OCCCCCNC(=O)[C@H](CC=2C=CC(=C(C2)Cl)[C@@H]3CC(=O)NS3(=O)=O)NS(=O)(=O)C4=CC=CC=C4)O

INT-850318-08-0-art-1-d

int

Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein Tyrosine Phosphatase 1B

Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B, Polam P, Crawley ML, Mclaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP, Burn TC, Hollis GF, Wynn R

to be published

2006

Enzymes

2cni

2cni-izf-2.00-d-1

0.05070843

endocrine

protein tyrosine phosphatase 1B

EC3.- (hydrolases)

phosphatases

PTP 1B

diabetes
obesity

dephosphorylation of insulin receptor and insulin receptor substrate tyrosine residues
prevention of insulin resistance

izf

2.00

INT-850318-08-0-art-1-d

COC(=O)C=1C(=CC=CC1OCCCCCNC(=O)[C@H](CC=2C=CC(=C(C2)Cl)[C@@H]3CC(=O)NS3(=O)=O)NS(=O)(=O)C4=CC=CC=C4)O

INT-850318-08-0-art-1-d

int

Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein Tyrosine Phosphatase 1B

Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B, Polam P, Crawley ML, Mclaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP, Burn TC, Hollis GF, Wynn R

to be published

2006

2cvu

RIR1_YEAST

P21524

K10807

DNA repair and recombination proteins

Eukaryotic Type

Other factors with a suspected DNA repair function

Modulation of nucleotide pools

RRM1; ribonucleoside-diphosphate reductase subunit M1

2cvu

2cvv

RIR1_YEAST

P21524

K10807

DNA repair and recombination proteins

Eukaryotic Type

Other factors with a suspected DNA repair function

Modulation of nucleotide pools

RRM1; ribonucleoside-diphosphate reductase subunit M1

2cvv

2czc

G3P_PYRHO

O59494

K00150

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)

2czc

2d1s

LUCI_LUCCR

P13129

KO_id not found

Others

2d1s

2d3s

LEC1_PSOTE

O24313

KO_id not found

Others

2d3s

2ddo

PDXK_ECOLI

P40191

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

2ddo

2ds1

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2ds1

2duv

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2duv

2e14

MK01_HUMAN

P28482

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

2e14

2e1q

XDH_HUMAN

P47989

K00106

Enzymes

Oxidoreductases

Acting on CH or CH2 groups

With oxygen as acceptor

Xanthine oxidase

2e1q

2e1w

ADA_BOVIN

P56658

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

2e1w

2e9u

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2e9u

2e9v

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2e9v

2egh

DXR_ECOLI

P45568

K00099

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

1-deoxy-D-xylulose-5-phosphate reductoisomerase

2egh

2egv

RSME_AQUAE

O66552

K09761

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

16S rRNA (uracil1498-N3)-methyltransferase

2egv

2euf

CGH2_SHV21

Q01043

KO_id not found

Others

2euf

Enzymes

2ew5

2ew5-y12-2.20-d-1

3.0797912

antiinfective

bacterial peptide deformylase

EC3.- (hydrolases)

amidases

PDF (H.pylori)

bacterial infection

interference with bacterial protein maturation

y12

2.20

913283-06-4

CC(=O)OC1=CC=C(C=C1OC(=O)C)C=CC(=O)NCCC=2C=CC=CC2

913283-06-4

cas

Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation

Cai J, Han C, Hu T, Zhang J, Wu D, Wang F, Liu Y, Ding J, Chen K, Yue J, Shen X, Jiang H

Protein Sci 15(9):2071-81

2006

10.1110/ps.062238406

Enzymes

2ew6

2ew6-y13-2.20-d-2

0.33407905

antiinfective

bacterial peptide deformylase

EC3.- (hydrolases)

amidases

PDF (H.pylori)

bacterial infection

interference with bacterial protein maturation

y13

2.20

N-trans-caffeoyltyramine

C=1C=C(C=CC1CCNC(=O)C=CC=2C=CC(=C(C2)O)O)O

103188-48-3

cas

Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation

Cai J, Han C, Hu T, Zhang J, Wu D, Wang F, Liu Y, Ding J, Chen K, Yue J, Shen X, Jiang H

Protein Sci 15(9):2071-81

2006

10.1110/ps.062238406

2ex1

Q15KI8_PASMD

Q15KI8

KO_id not found

Others

2ex1

2f1o

NQO1_HUMAN

P15559

K00355

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With a quinone or similar compound as acceptor

NAD(P)H dehydrogenase (quinone)

2f1o

2f8p

OBL_OBELO

Q27709

KO_id not found

Others

2f8p

2f99

O52646_9ACTO

O52646

KO_id not found

Others

2f99

2fes

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

2fes

2fhl

AVR4_CHICK

P56734

KO_id not found

Others

2fhl

2fqw

TMPC_TREPA

P29724

KO_id not found

Others

2fqw

2fqx

TMPC_TREPA

P29724

KO_id not found

Others

2fqx

Enzymes

2fub

2fub-aza-2.30-d-2

1159

antiinfective

aspergillus flavus urate oxidase

EC1.- (oxydo-reductases)

urate oxidases

Uox (A.flavus)

fungal infection

inhibition of fungal urate oxidase
interference with purine degradation

aza

2.30

8-azaxanthine

O=c1[nH]c(=O)c2[nH]nnc2[nH]1

1468-26-4

cas

High pressure macromolecular crystallography: the 140-MPa crystal structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric assembly

Colloc'h N, Girard E, Dhaussy AC, Kahn R, Ascone I, Mezouar M, Fourme R

Biochim Biophys Acta 1764(3):391-7

2006

10.1016/j.bbapap.2006.01.006

2g0e

QACR_STAHA

P0A0N5

KO_id not found

Others

2g0e

2gc2

G6PI_PYRFU

P83194

K01810

Enzymes

Isomerases

Intramolecular oxidoreductases

Interconverting aldoses and ketoses, and related compounds

Glucose-6-phosphate isomerase

2gc2

2gmv

PCKGC_HUMAN

P35558

K01596

Enzymes

Lyases

Carbon-carbon lyases

Carboxy-lyases

Phosphoenolpyruvate carboxykinase (GTP)

2gmv

2h15

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

2h15

2h5z

LYS1_MUSDO

Q7YT16

K00290

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Saccharopine dehydrogenase (NAD+, L-lysine-forming)

2h5z

2h7c

EST1_HUMAN

P23141

K01044

Enzymes

Hydrolases

Acting on ester bonds

Carboxylic-ester hydrolases

Carboxylesterase

2h7c

2h8m

ENPL_CANFA

P41148

K09487

Chaperones and folding catalysts

Heat shock proteins

HSP90

K09487 HSP90B, TRA1; heat shock protein 90kDa beta

Endoplasmic reticulum

2h8m

2hbh

VDRA_DANRE

Q9PTN2

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

2hbh

2hc4

VDRA_DANRE

Q9PTN2

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

2hc4

2hct

CD38_HUMAN

P28907

K01242

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

NAD+ nucleosidase

2hct

2hkj

TOP6B_SULSH

O05207

KO_id not found

Others

2hkj

2hl2

SYT_PYRAB

Q9UZ14

K01868

Enzymes

Ligases

Forming carbon-oxygen bonds

Ligases forming aminoacyl-tRNA and related compounds

Threonine---tRNA ligase

2hl2

2hoc

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

2hoc

2hog

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2hog

2hpv

AZOR_ENTFA

Q831B2

KO_id not found

Others

2hpv

2hxl

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2hxl

2hxm

UNG_HUMAN

P13051

K03648

DNA repair and recombination proteins

Prokaryotic Type

SSBR (single strand breaks repair)

BER (base exicision repair)

DNA glycosylases

2hxm

2hxz

CATS_HUMAN

P25774

K01368

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Cysteine endopeptidases

Cathepsin S

2hxz

2i0d

O38732_9HIV1

O38732

KO_id not found

Others

2i0d

2i2c

PPNK1_LISMO

Q8Y8D7

K00858

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

NAD+ kinase

2i2c

2i2d

PPNK1_LISMO

Q8Y8D7

K00858

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

NAD+ kinase

2i2d

2i3g

ARGC_MYCTU

P63562

K00145

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

N-acetyl-gamma-glutamyl-phosphate reductase

2i3g

2i4i

DDX3X_HUMAN

O00571

K11594

Enzymes

Hydrolases

Acting on acid anhydrides

Acting on acid anhydrides to facilitate cellular and subcellular movement

RNA helicase

2i4i

2ieg

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

2ieg

2igb

PYRR_BACCL

P41007

K02825

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uracil phosphoribosyltransferase

2igb

2igq

EHMT1_HUMAN

Q9H9B1

K11420

Chromosome

Eukaryotic Type

Histone modification proteins

HMTs (histone methyltransferases)

HKMTs (histone lysine methyltransferases)

2igq

2ih2

MTTA_THEAQ

P14385

KO_id not found

Others

2ih2

2ihq

ANDR_RAT

P15207

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

2ihq

2ikg

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

2ikg

2ikh

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

2ikh

2ilt

DHI1_HUMAN

P28845

K15680

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

11beta-hydroxysteroid dehydrogenase

2ilt

2imp

ALDA_ECOLI

P25553

K07248

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

Glycolaldehyde dehydrogenase

2imp

2io6

WEE1_HUMAN

P30291

K06632

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2io6

2iod

P93799_VITVI

P93799

KO_id not found

Others

2iod

2ipf

AK1CL_MOUSE

Q91WR5

KO_id not found

Others

2ipf

2iu8

LPXD_CHLT2

B0B7F9

K02536

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

2iu8

2ivs

RET_HUMAN

P07949

K05126

Cytokine receptors

Receptor tyrosine kinase

RTK class XIV (RET receptor family)

RET; proto-oncogene tyrosine-protein kinase Ret

Others

2ivs

2iw9

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2iw9

Other proteins

2izl

2izl-imi-1.48-d-2

108

antiinfective

streptavidin

Bacterial proteins

binding proteins

streptavidin

fundamental research

imi

1.48

iminobiotin

OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=N)N[C@H]12

13395-35-2

CAS

Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH

Katz BA

J Mol Biol 274(5):776-800

1997

10.1006/jmbi.1997.1444

2izu

KC1G3_HUMAN

Q9Y6M4

K08958

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2izu

2j07

PHR_THET8

P61497

K01669

Enzymes

Lyases

Carbon-carbon lyases

Other carbon-carbon lyases

Deoxyribodipyrimidine photo-lyase

2j07

2j08

PHR_THET8

P61497

K01669

Enzymes

Lyases

Carbon-carbon lyases

Other carbon-carbon lyases

Deoxyribodipyrimidine photo-lyase

2j08

2j2u

FA10_HUMAN

P00742

K01314

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F10; coagulation factor X

Others

2j2u

2j50

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2j50

2j51

SLK_HUMAN

Q9H2G2

K08836

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2j51

2j62

OGA_CLOP1

Q0TR53

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2j62

2j7c

BGLA_THEMA

Q08638

K01223

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

6-phospho-beta-glucosidase

2j7c

2j7d

BGLA_THEMA

Q08638

K01223

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

6-phospho-beta-glucosidase

2j7d

2j7e

BGLA_THEMA

Q08638

K01223

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

6-phospho-beta-glucosidase

2j7e

2j7y

ESR2_RAT

Q62986

K08551

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A2, ESR2; estrogen receptor beta

Others

2j7y

2j94

FA10_HUMAN

P00742

K01314

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F10; coagulation factor X

Others

2j94

2j9m

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2j9m

2jc6

KCC1D_HUMAN

Q8IU85

K08794

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Ca2+-calmodulin-dependent protein kinase

2jc6

2jf6

SG1_RAUSE

Q8GU20

KO_id not found

Others

2jf6

2jg7

Q4KTQ7_ACASC

Q4KTQ7

KO_id not found

Others

2jg7

2jh0

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

2jh0

2jh5

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

2jh5

2jh6

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

2jh6

2jj8

DNK_DROME

Q9XZT6

K05961

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Deoxynucleoside kinase

2jj8

2jjk

F16P1_HUMAN

P09467

K03841

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-monoester hydrolases

Fructose-bisphosphatase

2jjk

2jle

Q72547_9HIV1

Q72547

KO_id not found

Others

2jle

2jxr

CARP_YEAST

P07267

K01381

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Saccharopepsin

2jxr

2kzz

DPO1_ECOLI

P00582

K02335

Enzymes

Transferases

Transferring phosphorus-containing groups

Nucleotidyltransferases

DNA-directed DNA polymerase

2kzz

2nm2

FOLB_STAAU

P56740

K13649

Others

Cellular Processes

Transport and catabolism

Endocytosis

FOLR; folate receptor

2nm2

2nnl

P93799_VITVI

P93799

KO_id not found

Others

2nnl

2npn

Q6NIF5_CORDI

Q6NIF5

K02228

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Precorrin-6A synthase (deacetylating)

2npn

2nvc

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

2nvc

2nxx

A1JUG2_TRICA

A1JUG2

KO_id not found

Others

2nxx

2o06

SPEE_HUMAN

P19623

K00797

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Spermidine synthase

2o06

2o1u

ENPL_CANFA

P41148

K09487

Chaperones and folding catalysts

Heat shock proteins

HSP90

K09487 HSP90B, TRA1; heat shock protein 90kDa beta

Endoplasmic reticulum

2o1u

2o2c

G6PI_TRYBB

P13377

K01810

Enzymes

Isomerases

Intramolecular oxidoreductases

Interconverting aldoses and ketoses, and related compounds

Glucose-6-phosphate isomerase

2o2c

2o4j

VDR_RAT

P13053

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

2o4j

2o4r

VDR_RAT

P13053

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

2o4r

2o4s

POL_HV1BR

P03367

KO_id not found

Others

2o4s

2o6h

RISB1_BRUME

Q8YGH2

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

2o6h

2o7o

TETR4_ECOLX

P0ACT4

KO_id not found

Others

2o7o

2o8h

PDE10_RAT

Q9QYJ6

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

2o8h

2o9r

BGLB_PAEPO

P22505

K01223

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

6-phospho-beta-glucosidase

2o9r

2oaz

AMPM2_HUMAN

P50579

K01265

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aminopeptidases

Methionyl aminopeptidase

2oaz

2obx

RISB2_RHILO

Q986N2

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

2obx

2oht

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

2oht

2ohu

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

2ohu

2oi0

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

2oi0

2ojg

MK01_HUMAN

P28482

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

2ojg

2ojj

MK01_HUMAN

P28482

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

2ojj

2on6

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

2on6

2ops

POL_HV1H2

P04585

KO_id not found

Others

2ops

2os1

DEF_ENTFA

Q82ZJ0

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

2os1

2os3

DEF_STRP1

P68771

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

2os3

2our

PDE10_HUMAN

Q9Y233

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

2our

2ovh

PRGR_HUMAN

P06401

K08556

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C3, PGR; progesterone receptor

Others

2ovh

2oxn

NAGZ_VIBCH

Q9KU37

K01207

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Beta-N-acetylhexosaminidase

2oxn

2p0e

NRK1_HUMAN

Q9NWW6

K10524

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Ribosylnicotinamide kinase

2p0e

2pdg

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

2pdg

2pdw

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

2pdw

2pe2

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2pe2

2pnu

ANDR_HUMAN

P10275

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

2pnu

2pou

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

2pou

2pow

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

2pow

2prm

PYRD_HUMAN

Q02127

K00254

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With a quinone or related compound as acceptor

Dihydroorotate dehydrogenase (quinone)

2prm

2psj

LUCI_RENRE

P27652

KO_id not found

Others

2psj

2pvj

CSK2A_MAIZE

P28523

KO_id not found

Others

2pvj

2pvn

CSK2A_MAIZE

P28523

KO_id not found

Others

2pvn

2pw3

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

2pw3

2pza

NADE_BACAN

Q81RP3

K01916

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-ammonia (or amine) ligases (amide synthases)

NAD+ synthase

2pza

2pzi

PKNG_MYCTU

P65728

K14949

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2pzi

2q11

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

2q11

2q15

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

2q15

2q4h

GALT_ARATH

Q9FK51

K00965

Enzymes

Transferases

Transferring phosphorus-containing groups

Nucleotidyltransferases

UDP-glucose---hexose-1-phosphate uridylyltransferase

2q4h

2q54

O38732_9HIV1

O38732

KO_id not found

Others

2q54

2q55

O38732_9HIV1

O38732

KO_id not found

Others

2q55

2q5k

O38732_9HIV1

O38732

KO_id not found

Others

2q5k

2q6f

Q3Y5H1_9GAMC

Q3Y5H1

KO_id not found

Others

2q6f

2q7o

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

2q7o

2q8g

PDK1_HUMAN

Q15118

K12077

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

[pyruvate dehydrogenase (acetyl-transferring)] kinase

2q8g

2q8i

PDK3_HUMAN

Q15120

K00898

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

[pyruvate dehydrogenase (acetyl-transferring)] kinase

2q8i

2q95

AMPM_ECOLI

P0AE18

K01265

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aminopeptidases

Methionyl aminopeptidase

2q95

2q9u

Q86QZ1_GIAIN

Q86QZ1

KO_id not found

Others

2q9u

2qa9

PRTB_STRGR

P00777

K01336

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Cerevisin

2qa9

2qab

ESR1_HUMAN

P03372

K08550

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A1, ESR1; estrogen receptor alpha

Others

2qab

2qbu

O27402_METTH

O27402

K03394

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Precorrin-2 C20-methyltransferase

2qbu

2qgt

ESR1_HUMAN

P03372

K08550

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A1, ESR1; estrogen receptor alpha

Others

2qgt

2qhx

PTR1_LEIMA

Q01782

KO_id not found

Others

2qhx

2qhy

O38732_9HIV1

O38732

KO_id not found

Others

2qhy

2qi5

O38732_9HIV1

O38732

KO_id not found

Others

2qi5

2qkm

DCP1_SCHPO

Q9P805

K12611

Enzymes

Hydrolases

-.-

-.-.-

2qkm

2qkn

CKX1_MAIZE

Q9T0N8

K00279

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With other acceptors

Cytokinin dehydrogenase

2qkn

2qln

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

2qln

2qn7

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

2qn7

2qn8

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

2qn8

2qn9

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

2qn9

2qnb

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

2qnb

2qrq

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

2qrq

2qtg

MTN1_ARATH

Q9T0I8

K01244

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

Methylthioadenosine nucleosidase

2qtg

2qtn

Q6HT60_BACAN

Q6HT60

K00969

Enzymes

Transferases

Transferring phosphorus-containing groups

Nucleotidyltransferases

Nicotinate-nucleotide adenylyltransferase

2qtn

2qtt

MTN1_ARATH

Q9T0I8

K01244

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

Methylthioadenosine nucleosidase

2qtt

2qv7

DAGK_STAAR

Q6GFF9

KO_id not found

Others

2qv7

2qvn

A5KE01_PLAVS

A5KE01

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

2qvn

2qwx

NQO2_HUMAN

P16083

K08071

Enzymes

Oxidoreductases

Acting on diphenols and related substances as donors

With other acceptors

Ribosyldihydronicotinamide dehydrogenase (quinone)

2qwx

2qzr

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

2qzr

2r0p

Q8KI25_NOCAE

Q8KI25

KO_id not found

Others

2r0p

2r2l

Q5RKJ4_RAT

Q5RKJ4

KO_id not found

Others

2r2l

2r3j

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2r3j

2r3k

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2r3k

2r3m

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2r3m

2r64

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2r64

2r6h

Q7MT22_PORGI

Q7MT22

K00351

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With a quinone or similar compound as acceptor

2r6h

2r6r

FTSZ_AQUAE

O66809

KO_id not found

Others

2r6r

2rbe

DHI1_HUMAN

P28845

K15680

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

11beta-hydroxysteroid dehydrogenase

2rbe

2rcw

PARP1_HUMAN

P09874

K10798

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

2rcw

2rh6

Q8PIS1_XANAC

Q8PIS1

KO_id not found

Others

2rh6

2rh9

TRPA_SALTY

P00929

K01695

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Tryptophan synthase

2rh9

2rhr

ACT3_STRCO

P16544

K12420

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

2rhr

2rhs

SYFA_STAHJ

Q4L5E3

K01889

Enzymes

Ligases

Forming carbon-oxygen bonds

Ligases forming aminoacyl-tRNA and related compounds

Phenylalanine---tRNA ligase

2rhs

2rht

BPHD_BURXL

P47229

K10222

Enzymes

Hydrolases

Acting on carbon-carbon bonds

In ketonic substances

2,6-dioxo-6-phenylhexa-3-enoate hydrolase

2rht

Signaling proteins

2trt

2trt-tac-2.50-d-1-s

1816

antiinfective

tetracycline repressor protein

Intracellular transduction

DNA repressors

TetR

fundamental research
bacterial infection

resistance to tetracycline antibiotics at the transcriptional level

tac

2.50

tetracycline

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O

60-54-8

cas

Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance

Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W

Science 264(5157):418-20

1994

2tsr

TYSY_RAT

P45352

K00560

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Thymidylate synthase

2tsr

2upj

POL_HV1BR

P03367

KO_id not found

Others

2upj

2usn

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

2usn

2uue

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2uue

2uv2

SLK_HUMAN

Q9H2G2

K08836

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2uv2

2uxh

TTGR_PSEPU

Q9AIU0

KO_id not found

Others

2uxh

2uxz

POL_HV1B1

P03366

KO_id not found

Others

2uxz

2uy0

POL_HV1B1

P03366

KO_id not found

Others

2uy0

2uzd

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2uzd

2uzh

A0R559_MYCS2

A0R559

K01770

Enzymes

Lyases

Phosphorus-oxygen lyases

Phosphorus-oxygen lyases (only sub-subclass identified to date)

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

2uzh

2uzo

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2uzo

2v2q

ISPE_AQUAE

O67060

K00919

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

2v2q

2v2z

ISPE_AQUAE

O67060

K00919

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

2v2z

2v4l

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

2v4l

2v57

Q58L87_MYCSM

Q58L87

KO_id not found

Others

2v57

2v58

ACCC_ECOLI

P24182

K01961

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

2v58

2v59

ACCC_ECOLI

P24182

K01961

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

2v59

2v5a

ACCC_ECOLI

P24182

K01961

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

2v5a

2v8p

ISPE_AQUAE

O67060

K00919

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

2v8p

2va6

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

2va6

2va7

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

2va7

2vap

FTSZ1_METJA

Q57816

KO_id not found

Others

2vap

2vf3

ISPE_AQUAE

O67060

K00919

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

2vf3

2vg5

POL_HV1B1

P03366

KO_id not found

Others

2vg5

2vg7

POL_HV1B1

P03366

KO_id not found

Others

2vg7

2vgo

AUKBA_XENLA

Q6DE08

K11479

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2vgo

2vi5

RISB_MYCTU

P66034

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

2vi5

2vig

ACADS_HUMAN

P16219

K00248

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With a flavin as acceptor

Short-chain acyl-CoA dehydrogenase

2vig

2vkh

Q46342_CLOSO

Q46342

KO_id not found

Others

2vkh

2vl8

Q46342_CLOSO

Q46342

KO_id not found

Others

2vl8

2vpr

Q799E2_PASMD

Q799E2

KO_id not found

Others

2vpr

2vqs

DNK_DROME

Q9XZT6

K05961

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Deoxynucleoside kinase

2vqs

2vrx

AUKBA_XENLA

Q6DE08

K11479

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2vrx

2vto

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2vto

2vur

OGA_CLOP1

Q0TR53

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2vur

2vvs

OGA_BACTN

Q89ZI2

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2vvs

2vwx

EPHB4_HUMAN

P54760

K05113

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

2vwx

2vwy

EPHB4_HUMAN

P54760

K05113

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

2vwy

2vwz

EPHB4_HUMAN

P54760

K05113

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

2vwz

2vx0

EPHB4_HUMAN

P54760

K05113

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

2vx0

2vx1

EPHB4_HUMAN

P54760

K05113

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

2vx1

2vz6

KCC2A_HUMAN

Q9UQM7

K04515

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Ca2+-calmodulin-dependent protein kinase

2vz6

2vze

ACS2A_HUMAN

Q08AH3

K01896

Enzymes

Ligases

Forming carbon-sulfur bonds

Acid-thiol ligases

Butyrate---CoA ligase

2vze

2w1e

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2w1e

2w1h

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2w1h

2w3r

O54051_RHOCA

O54051

KO_id not found

Others

2w3r

2w3s

O54050_RHOCA

O54050

KO_id not found

Others

2w3s

2w3v

O30463_MYCAV

O30463

KO_id not found

Others

2w3v

2w4o

KCC4_HUMAN

Q16566

K05869

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Ca2+-calmodulin-dependent protein kinase

2w4o

2w4x

OGA_BACTN

Q89ZI2

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2w4x

2w6m

ACCC_ECOLI

P24182

K01961

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

2w6m

2w6n

ACCC_ECOLI

P24182

K01961

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

2w6n

2w71

ACCC_ECOLI

P24182

K01961

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

2w71

2w8r

SSDH_HUMAN

P51649

K00139

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

Succinate-semialdehyde dehydrogenase (NAD+)

2w8r

2w98

PTGR2_HUMAN

Q8N8N7

K13949

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With NAD+ or NADP+ as acceptor

15-oxoprostaglandin 13-oxidase

2w98

2wa9

CLPS_ECOLI

P0A8Q6

KO_id not found

Others

2wa9

2wb5

OGA_CLOP1

Q0TR53

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2wb5

2wbk

Q8AAK6_BACTN

Q8AAK6

K01192

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Beta-mannosidase

2wbk

2wca

OGA_BACTN

Q89ZI2

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2wca

2wd1

MET_HUMAN

P08581

K05099

Cellular antigens

Non-CD molecules

MET; met proto-oncogene (hepatocyte growth factor receptor)

Others

2wd1

2wd7

O76290_TRYBB

O76290

KO_id not found

Others

2wd7

2wea

PENP_PENJA

P00798

KO_id not found

Others

2wea

2web

PENP_PENJA

P00798

KO_id not found

Others

2web

2wec

PENP_PENJA

P00798

KO_id not found

Others

2wec

2weh

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

2weh

2wgs

GLNA1_MYCTU

P0A590

K01915

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-ammonia (or amine) ligases (amide synthases)

Glutamate---ammonia ligase

2wgs

2wks

AROQ_HELPY

Q48255

K03786

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

3-dehydroquinate dehydratase

2wks

2wkz

POL_HV1B1

P03366

KO_id not found

Others

2wkz

2wl0

POL_HV1B1

P03366

KO_id not found

Others

2wl0

2wmd

NMRL1_HUMAN

Q9HBL8

KO_id not found

Others

2wmd

2wmr

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2wmr

2wms

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2wms

2wn9

Q8WSF8_APLCA

Q8WSF8

KO_id not found

Others

2wn9

2wo9

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

2wo9

2won

POL_HV1H2

P04585

KO_id not found

Others

2won

2wqb

TIE2_HUMAN

Q02763

K05121

Cellular antigens

CD (clusters of differentiation) molecules

CD202b; TEK tyrosine kinase, endothelial

Others

2wqb

2wtc

CHK2_HUMAN

O96017

K06641

DNA repair and recombination proteins

Eukaryotic Type

Check point factors

Other check point factors

CHK2; serine-threonine-protein kinase Chk2

2wtc

2wtd

CHK2_HUMAN

O96017

K06641

DNA repair and recombination proteins

Eukaryotic Type

Check point factors

Other check point factors

CHK2; serine-threonine-protein kinase Chk2

2wtd

2wu6

CLK3_HUMAN

P49761

K08823

Enzymes

Transferases

Transferring phosphorus-containing groups

Dual-specificity kinases (those acting on Ser-Thr and Tyr residues)

Dual-specificity kinase

2wu6

2wuf

HSAD_MYCTU

P96851

K16050

Enzymes

Hydrolases

Acting on carbon-carbon bonds

In ketonic substances

4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

2wuf

2wvz

Q8A0N1_BACTN

Q8A0N1

KO_id not found

Others

2wvz

2ww3

Q8A0N1_BACTN

Q8A0N1

KO_id not found

Others

2ww3

2wxf

Q3UDT3_MOUSE

Q3UDT3

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

2wxf

2wxm

Q3UDT3_MOUSE

Q3UDT3

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

2wxm

2wxn

Q3UDT3_MOUSE

Q3UDT3

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

2wxn

2wxp

Q3UDT3_MOUSE

Q3UDT3

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

2wxp

2wxq

Q3UDT3_MOUSE

Q3UDT3

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

2wxq

2wxv

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2wxv

2wyg

FA10_HUMAN

P00742

K01314

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F10; coagulation factor X

Others

2wyg

2wzh

OGA_BACTN

Q89ZI2

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2wzh

2x0y

OGA_CLOP1

Q0TR53

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2x0y

2x1n

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

2x1n

2x2l

RET_HUMAN

P07949

K05126

Cytokine receptors

Receptor tyrosine kinase

RTK class XIV (RET receptor family)

RET; proto-oncogene tyrosine-protein kinase Ret

Others

2x2l

2x38

Q3UDT3_MOUSE

Q3UDT3

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

2x38

2x7f

TNIK_HUMAN

Q9UKE5

K08840

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2x7f

2x7t

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

2x7t

2x9f

EPHB4_HUMAN

P54760

K05113

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

2x9f

2x9g

O76290_TRYBB

O76290

KO_id not found

Others

2x9g

2x9n

O76290_TRYBB

O76290

KO_id not found

Others

2x9n

2xb9

AROQ_HELPY

Q48255

K03786

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

3-dehydroquinate dehydratase

2xb9

2xhm

ACE_DROME

Q10714

K01283

Cellular antigens

CD (clusters of differentiation) molecules

CD143; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Others

2xhm

2xiq

MUTA_HUMAN

P22033

K01847

Enzymes

Isomerases

Intramolecular transferases

Transferring other groups

Methylmalonyl-CoA mutase

2xiq

2xm1

OGA_BACTN

Q89ZI2

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2xm1

2xm2

OGA_BACTN

Q89ZI2

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

2xm2

2xng

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2xng

2xoc

CHFR_HUMAN

Q96EP1

K10644

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Ubiquitin---protein ligase

2xoc

2xpu

TETR4_ECOLX

P0ACT4

KO_id not found

Others

2xpu

2xrl

TETR4_ECOLX

P0ACT4

KO_id not found

Others

2xrl

2xsb

Q2CEE3_9RHOB

Q2CEE3

KO_id not found

Others

2xsb

2xtb

Q584S0_TRYB2

Q584S0

K00856

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Adenosine kinase

2xtb

2xtk

B0Y2Y2_ASPFC

B0Y2Y2

KO_id not found

Others

2xtk

2xxb

LDH_THET8

Q5SJA1

K00016

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

L-lactate dehydrogenase

2xxb

2xye

POL_HV1B1

P03366

KO_id not found

Others

2xye

2xyf

POL_HV1B1

P03366

KO_id not found

Others

2xyf

2xyu

EPHA4_MOUSE

Q03137

K05105

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

2xyu

2y4o

B4EL89_BURCJ

B4EL89

K01912

Enzymes

Ligases

Forming carbon-sulfur bonds

Acid-thiol ligases

Phenylacetate---CoA ligase

2y4o

2y5k

F16P1_HUMAN

P09467

K03841

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-monoester hydrolases

Fructose-bisphosphatase

2y5k

2ybo

P95417_PSEAI

P95417

K02303

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Uroporphyrinogen-III C-methyltransferase

2ybo

2ybu

CHIA_HUMAN

Q9BZP6

K01183

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Chitinase

2ybu

2ydo

AA2AR_HUMAN

P29274

K04266

G Protein-Coupled Receptors

Class A. Rhodopsin family

Base and nucleoside

Adenosine

Adenosine receptor A2a

2ydo

9606

2ydv

AA2AR_HUMAN

P29274

K04266

G Protein-Coupled Receptors

Class A. Rhodopsin family

Base and nucleoside

Adenosine

Adenosine receptor A2a

2ydv

9606

2yer

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2yer

2yjd

ESR2_HUMAN

Q92731

K08551

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A2, ESR2; estrogen receptor beta

Others

2yjd

2yk5

LST_NEIMB

P72097

K00785

Enzymes

Transferases

Glycosyltransferases

Transferring other glycosyl groups

2yk5

2yk7

LST_NEIMB

P72097

K00785

Enzymes

Transferases

Glycosyltransferases

Transferring other glycosyl groups

2yk7

2yxu

PDXK_HUMAN

O00764

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

2yxu

2z0y

Q5SKI6_THET8

Q5SKI6

K09761

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

16S rRNA (uracil1498-N3)-methyltransferase

2z0y

2z2w

WEE1_HUMAN

P30291

K06632

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2z2w

2z4t

A8QYL1_9GAMM

A8QYL1

KO_id not found

Others

2z4t

2z6i

Q9FBC5_STREE

Q9FBC5

KO_id not found

Others

2z6i

2z6r

DPHB_PYRHO

O58456

K00586

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Diphthine synthase

2z6r

2z7g

ADA_BOVIN

P56658

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

2z7g

2z7l

MK01_RAT

P63086

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

2z7l

2z98

AZOR_ECOLI

P41407

KO_id not found

Others

2z98

2zba

O94197_FUSSP

O94197

KO_id not found

Others

2zba

2zdv

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

2zdv

2zff

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

2zff

2zfp

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

2zfp

2zjw

CSK21_HUMAN

P68400

K03097

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

2zjw

2zl2

CLPP_HELPY

P56156

K01358

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Endopeptidase Clp

2zl2

2zm1

LCK_HUMAN

P06239

K05856

CAM ligands

Immunoglobulin Superfamily

Immune system

CD2 family

CD48, BCM1; CD48 antigen [KO- ]

2zm1

2zoq

MK03_HUMAN

P27361

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

2zoq

2zoz

Q8NMG3_CORGL

Q8NMG3

KO_id not found

Others

2zoz

2zv9

LYN_MOUSE

P25911

K05854

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

2zv9

2zvb

Q53WA6_THET8

Q53WA6

K05934

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Precorrin-3B C17-methyltransferase

2zvb

2zwi

A5LHX0_PHOPO

A5LHX0

KO_id not found

Others

2zwi

3a14

DXR_THEMA

Q9WZZ1

K00099

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

1-deoxy-D-xylulose-5-phosphate reductoisomerase

3a14

3a26

TYW2_PYRHO

O58523

K07055

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

3a26

3a2q

NYLA_FLASK

P13398

KO_id not found

Others

3a2q

3a37

GET3_YEAST

Q12154

K01551

Enzymes

Hydrolases

Acting on acid anhydrides

Acting on acid anhydrides to catalyse transmembrane movement of substances

Arsenite-transporting ATPase

3a37

3a3w

Q93LD7_RHIRD

Q93LD7

KO_id not found

Others

3a3w

3a3z

VDR_HUMAN

P11473

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

3a3z

3ac1

LCK_HUMAN

P06239

K05856

CAM ligands

Immunoglobulin Superfamily

Immune system

CD2 family

CD48, BCM1; CD48 antigen [KO- ]

3ac1

3ac3

LCK_HUMAN

P06239

K05856

CAM ligands

Immunoglobulin Superfamily

Immune system

CD2 family

CD48, BCM1; CD48 antigen [KO- ]

3ac3

3ad6

LCK_HUMAN

P06239

K05856

CAM ligands

Immunoglobulin Superfamily

Immune system

CD2 family

CD48, BCM1; CD48 antigen [KO- ]

3ad6

3adt

PPARG_HUMAN

P37231

K08530

Nuclear receptors

Thyroid hormone like

C. Peroxisome proliferator-activated receptor (PPAR)

NR1C3, PPARG; peroxisome proliferator-activated receptor gamma

Others

3adt

3afo

POS5_YEAST

Q06892

KO_id not found

Others

3afo

3ais

Q1XH05_WHEAT

Q1XH05

KO_id not found

Others

3ais

3ama

KAPCA_HUMAN

P17612

K04345

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

CAMP-dependent protein kinase

3ama

3amb

KAPCA_HUMAN

P17612

K04345

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

CAMP-dependent protein kinase

3amb

3anx

SPEE_THET8

Q5SK28

K00797

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Spermidine synthase

3anx

3atw

R1A_CVHSA

P0C6U8

KO_id not found

Others

3atw

3aty

Q8I6L9_TRYCR

Q8I6L9

KO_id not found

Others

3aty

3atz

Q8I6L9_TRYCR

Q8I6L9

KO_id not found

Others

3atz

3avp

COAA_MYCTU

P63810

K00867

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pantothenate kinase

3avp

3aw0

R1A_CVHSA

P0C6U8

KO_id not found

Others

3aw0

3ax8

VDR_HUMAN

P11473

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

3ax8

3b1n

Q2SZE4_BURTA

Q2SZE4

K00856

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Adenosine kinase

3b1n

3b1q

Q2SZE4_BURTA

Q2SZE4

K00856

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Adenosine kinase

3b1q

3b2s

Q9HDE2_GIBZA

Q9HDE2

KO_id not found

Others

3b2s

3b4f

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3b4f

3b66

ANDR_HUMAN

P10275

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

3b66

3b68

ANDR_HUMAN

P10275

K08557

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C4, AR; androgen receptor

Others

3b68

3b92

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3b92

3b9o

A4IU28_GEOTN

A4IU28

KO_id not found

Others

3b9o

3baa

DNLJ_ENTFA

Q837V6

K01972

Enzymes

Ligases

Forming phosphoric-ester bonds

Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

DNA ligase (NAD+)

3baa

3bab

DNLJ_ENTFA

Q837V6

K01972

Enzymes

Ligases

Forming phosphoric-ester bonds

Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

DNA ligase (NAD+)

3bab

3bac

DNLJ_HAEIN

P43813

K01972

Enzymes

Ligases

Forming phosphoric-ester bonds

Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

DNA ligase (NAD+)

3bac

3bdj

XDH_BOVIN

P80457

K00106

Enzymes

Oxidoreductases

Acting on CH or CH2 groups

With oxygen as acceptor

Xanthine oxidase

3bdj

3bea

CSF1R_HUMAN

P07333

K05090

Cellular antigens

CD (clusters of differentiation) molecules

CD115; colony stimulating factor 1 receptor (macrophage)

Others

3bea

3bgi

TPMT_MOUSE

O55060

K00569

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Thiopurine S-methyltransferase

3bgi

3bgs

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3bgs

3bhh

KCC2B_HUMAN

Q13554

K04515

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Ca2+-calmodulin-dependent protein kinase

3bhh

3bhj

CBR1_HUMAN

P16152

K00079

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Carbonyl reductase (NADPH)

3bhj

3bhm

CBR1_HUMAN

P16152

K00079

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Carbonyl reductase (NADPH)

3bhm

3bhu

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3bhu

3bhv

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3bhv

3bjc

PDE5A_HUMAN

O76074

K13762

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-GMP phosphodiesterase

3bjc

3bjh

Q9U9J6_APIME

Q9U9J6

KO_id not found

Others

3bjh

3bk2

Q72JJ7_THET2

Q72JJ7

KO_id not found

Others

3bk2

3bl9

DCPS_HUMAN

Q96C86

K12584

Enzymes

Hydrolases

-.-

-.-.-

3bl9

3bla

DCPS_HUMAN

Q96C86

K12584

Enzymes

Hydrolases

-.-

-.-.-

3bla

3bll

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

3bll

3blo

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

3blo

3bmc

O76290_TRYBB

O76290

KO_id not found

Others

3bmc

3bo5

SETMR_HUMAN

Q53H47

K11433

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Histone-lysine N-methyltransferase

3bo5

3bpr

MERTK_HUMAN

Q12866

K05117

Cytokine receptors

Receptor tyrosine kinase

RTK class IX (AXL receptor family)

MERTK, MER; c-mer proto-oncogene tyrosine kinase

Others

3bpr

3bqm

ITAL_HUMAN

P20701

K05718

Cellular antigens

CD (clusters of differentiation) molecules

CD11a; integrin alpha L

Others

3bqm

3bus

Q8KI52_NOCAE

Q8KI52

KO_id not found

Others

3bus

3bw2

Q9FDD4_9ACTO

Q9FDD4

KO_id not found

Others

3bw2

3bxr

POL_HV1A2

P03369

KO_id not found

Others

3bxr

3bxs

POL_HV1A2

P03369

KO_id not found

Others

3bxs

3bxx

P93799_VITVI

P93799

KO_id not found

Others

3bxx

3bys

LCK_HUMAN

P06239

K05856

CAM ligands

Immunoglobulin Superfamily

Immune system

CD2 family

CD48, BCM1; CD48 antigen [KO- ]

3bys

3bz8

MYS2_DICDI

P08799

K10352

Cytoskeleton proteins

Eukaryotic cytoskeleton proteins

Actin filaments - Microfilaments

Actin-binding proteins

Myosins

3bz8

3bzu

DHI1_HUMAN

P28845

K15680

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

11beta-hydroxysteroid dehydrogenase

3bzu

3c79

Q8WSF8_APLCA

Q8WSF8

KO_id not found

Others

3c79

3cb2

TBG1_HUMAN

P23258

K10389

Cytoskeleton proteins

Eukaryotic cytoskeleton proteins

Microtubules

Tubulins

TUBG; tubulin gamma

3cb2

3cds

PPARG_HUMAN

P37231

K08530

Nuclear receptors

Thyroid hormone like

C. Peroxisome proliferator-activated receptor (PPAR)

NR1C3, PPARG; peroxisome proliferator-activated receptor gamma

Others

3cds

3cf6

A2ASW3_MOUSE

A2ASW3

KO_id not found

Others

3cf6

3cow

PANC_MYCTU

P0A5R0

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

3cow

3coy

PANC_MYCTU

P0A5R0

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

3coy

3coz

PANC_MYCTU

P0A5R0

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

3coz

3cpb

VGFR2_HUMAN

P35968

K05098

Cellular antigens

CD (clusters of differentiation) molecules

CD309; kinase insert domain receptor

Others

3cpb

3cqe

WEE1_HUMAN

P30291

K06632

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3cqe

3cw9

Q8GN86_9BURK

Q8GN86

KO_id not found

Others

3cw9

3cy3

PIM1_HUMAN

P11309

K04702

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3cy3

3d14

AURKA_MOUSE

P97477

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3d14

3d15

AURKA_MOUSE

P97477

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3d15

3d28

POLG_HCVBK

P26663

KO_id not found

Others

3d28

3d2i

AURKA_MOUSE

P97477

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3d2i

3d2k

AURKA_MOUSE

P97477

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3d2k

3d2r

PDK4_HUMAN

Q16654

K00898

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

[pyruvate dehydrogenase (acetyl-transferring)] kinase

3d2r

3d7k

Q9F4L3_PSEFL

Q9F4L3

KO_id not found

Others

3d7k

3d8w

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3d8w

3d9z

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3d9z

3da9

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

3da9

3dba

PDE6C_CHICK

P52731

K13757

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-GMP phosphodiesterase

3dba

3dbs

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3dbs

3dbu

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3dbu

3dcc

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3dcc

3dcj

P71554_MYCTU

P71554

K11175

Enzymes

Transferases

Transferring one-carbon groups

Hydroxymethyl-, formyl- and related transferases

Phosphoribosylglycinamide formyltransferase

3dcj

3dcv

PIM1_HUMAN

P11309

K04702

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3dcv

3ddu

PPCE_HUMAN

P48147

K01322

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Prolyl oligopeptidase

3ddu

3dh7

Q53W52_THET8

Q53W52

K01823

Enzymes

Isomerases

Intramolecular oxidoreductases

Transposing C=C bonds

Isopentenyl-diphosphate Delta-isomerase

3dh7

3dhe

DHB1_HUMAN

P14061

K00044

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Estradiol 17beta-dehydrogenase

3dhe

3dhy

SAHH_MYCTU

P60176

K01251

Enzymes

Hydrolases

Acting on ether bonds

Thioether and trialkylsulfonium hydrolases

Adenosylhomocysteinase

3dhy

3di6

POL_HV1H2

P04585

KO_id not found

Others

3di6

3djk

POL_HV1BR

P03367

KO_id not found

Others

3djk

3dk1

POL_HV1BR

P03367

KO_id not found

Others

3dk1

3dn5

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

3dn5

3dng

MMP8_HUMAN

P22894

K01402

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Neutrophil collagenase

3dng

3dox

POL_HV1H2

P04585

KO_id not found

Others

3dox

3dpk

CSF1R_HUMAN

P07333

K05090

Cellular antigens

CD (clusters of differentiation) molecules

CD115; colony stimulating factor 1 receptor (macrophage)

Others

3dpk

3drw

K6PF_PYRHO

O59355

K00850

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

6-phosphofructokinase

3drw

3dsl

VM3BP_BOTJA

O93523

KO_id not found

Others

3dsl

3dtc

M3K9_HUMAN

P80192

K04417

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase kinase kinase

3dtc

3dv1

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3dv1

3dxz

TRMB_ECOLI

P0A8I5

K03439

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

TRNA (guanine46-N7)-methyltransferase

3dxz

3dyl

PDE9A_HUMAN

O76083

K13761

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-GMP phosphodiesterase

3dyl

3dz4

DCAM_HUMAN

P17707

K01611

Enzymes

Lyases

Carbon-carbon lyases

Carboxy-lyases

Adenosylmethionine decarboxylase

3dz4

3dz6

DCAM_HUMAN

P17707

K01611

Enzymes

Lyases

Carbon-carbon lyases

Carboxy-lyases

Adenosylmethionine decarboxylase

3dz6

3dz7

DCAM_HUMAN

P17707

K01611

Enzymes

Lyases

Carbon-carbon lyases

Carboxy-lyases

Adenosylmethionine decarboxylase

3dz7

3e5a

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3e5a

3e6e

Q837J0_ENTFA

Q837J0

K01775

Enzymes

Isomerases

Racemases and epimerases

Acting on amino acids and derivatives

Alanine racemase

3e6e

3e6n

NOS2_MOUSE

P29477

K13241

Enzymes

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Nitric-oxide synthase (NADPH dependent)

3e6n

3e7v

HASP_HUMAN

Q8TF76

K16315

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3e7v

3e8r

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3e8r

3e9z

Q9BMI9_SCHMA

Q9BMI9

KO_id not found

Others

3e9z

3edo

Q5FKC3_LACAC

Q5FKC3

KO_id not found

Others

3edo

3elz

Q6IMW5_DANRE

Q6IMW5

KO_id not found

Others

3elz

3ene

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3ene

3eou

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

3eou

3eq7

PPCE_PIG

P23687

K01322

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Prolyl oligopeptidase

3eq7

3etn

Q5LIW1_BACFN

Q5LIW1

K06041

Enzymes

Isomerases

Intramolecular oxidoreductases

Interconverting aldoses and ketoses, and related compounds

Arabinose-5-phosphate isomerase

3etn

3euf

UPP1_HUMAN

Q16831

K00757

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uridine phosphorylase

3euf

3ewj

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3ewj

3ewr

R1A_CVH22

P0C6U2

KO_id not found

Others

3ewr

3eyg

JAK1_HUMAN

P23458

K11217

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

3eyg

3f10

Q97FM4_CLOAB

Q97FM4

K03660

Enzymes

Lyases

Carbon-oxygen lyases

Other carbon-oxygen lyases

DNA-(apurinic or apyrimidinic site) lyase

3f10

3f16

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3f16

3f1q

PYRD_HUMAN

Q02127

K00254

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With a quinone or related compound as acceptor

Dihydroorotate dehydrogenase (quinone)

3f1q

3f2v

Q73QT9_TREDE

Q73QT9

KO_id not found

Others

3f2v

3f3z

Q5CYL9_CRYPI

Q5CYL9

K13412

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3f3z

3f4x

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3f4x

3f6r

FLAV_DESDE

P26492

K05278

Enzymes

Oxidoreductases

Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2

With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Flavonol synthase

3f6r

3f7b

CAH4_HUMAN

P22748

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3f7b

3f7o

Q01471_9HYPO

Q01471

KO_id not found

Others

3f7o

3f7z

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

3f7z

3f88

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

3f88

3f8p

Q97W27_SULSO

Q97W27

K00384

Enzymes

Oxidoreductases

Acting on a sulfur group of donors

With NAD+ or NADP+ as acceptor

Thioredoxin-disulfide reductase

3f8p

3f8w

Q9BMI9_SCHMA

Q9BMI9

KO_id not found

Others

3f8w

3faz

Q9BMI9_SCHMA

Q9BMI9

KO_id not found

Others

3faz

3fcf

UNG_HUMAN

P13051

K03648

DNA repair and recombination proteins

Prokaryotic Type

SSBR (single strand breaks repair)

BER (base exicision repair)

DNA glycosylases

3fcf

3fci

UNG_HUMAN

P13051

K03648

DNA repair and recombination proteins

Prokaryotic Type

SSBR (single strand breaks repair)

BER (base exicision repair)

DNA glycosylases

3fci

3fdn

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3fdn

3fh0

A6T8F5_KLEP7

A6T8F5

KO_id not found

Others

3fh0

3fhx

PDXK_HUMAN

O00764

K00868

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Pyridoxal kinase

3fhx

3fi4

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fi4

3fiu

Q2A4B6_FRATH

Q2A4B6

K01916

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-ammonia (or amine) ligases (amide synthases)

NAD+ synthase

3fiu

3fkl

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fkl

3fl8

Q81R22_BACAN

Q81R22

K00287

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Dihydrofolate reductase

3fl8

3fls

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fls

3flw

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3flw

3fly

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fly

3flz

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3flz

3fmh

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fmh

3fmk

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fmk

3fml

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fml

3fmn

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fmn

3frg

PDE4B_HUMAN

Q07343

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

3frg

3frq

Q9EVJ6_ECOLX

Q9EVJ6

KO_id not found

Others

3frq

3fsj

MDLC_PSEPU

P20906

KO_id not found

Others

3fsj

3fsk

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3fsk

3ftf

RSMA_AQUAE

O67680

K02528

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

16S rRNA (adenine1518-N6-adenine1519-N6)-dimethyltransferase

3ftf

3ftv

LKHA4_HUMAN

P09960

K01254

Enzymes

Hydrolases

Acting on ether bonds

Ether hydrolases

Leukotriene-A4 hydrolase

3ftv

3fuj

LKHA4_HUMAN

P09960

K01254

Enzymes

Hydrolases

Acting on ether bonds

Ether hydrolases

Leukotriene-A4 hydrolase

3fuj

3fuu

RSMA_THET8

Q5SM60

K02528

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

16S rRNA (adenine1518-N6-adenine1519-N6)-dimethyltransferase

3fuu

3fuw

RSMA_THET8

Q5SM60

K02528

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

16S rRNA (adenine1518-N6-adenine1519-N6)-dimethyltransferase

3fuw

3fxw

MAPK3_HUMAN

Q16644

K04444

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3fxw

3fxx

EPHA3_HUMAN

P29320

K05104

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

3fxx

3fzr

FAK2_HUMAN

Q14289

K05871

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

3fzr

3fzs

FAK2_HUMAN

Q14289

K05871

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

3fzs

3g0y

FABF_ECOLI

P0AAI5

K09458

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Beta-ketoacyl-acyl-carrier-protein synthase II

3g0y

3g11

FABF_ECOLI

P0AAI5

K09458

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Beta-ketoacyl-acyl-carrier-protein synthase II

3g11

3g3e

OXDA_HUMAN

P14920

K00273

Enzymes

Oxidoreductases

Acting on the CH-NH2 group of donors

With oxygen as acceptor

D-amino-acid oxidase

3g3e

3g4k

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

3g4k

3g5k

DEFM_HUMAN

Q9HBH1

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

3g5k

3gc0

A8BZ95_GIAIC

A8BZ95

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3gc0

3gcq

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3gcq

3gcu

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3gcu

3gga

Q9Q2G8_9HIV1

Q9Q2G8

KO_id not found

Others

3gga

3ggf

MST4_HUMAN

Q9P289

K16314

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3ggf

3gid

ACACB_HUMAN

O00763

K11262

Enzymes

Ligases

Forming carbon-nitrogen bonds

Other carbon-nitrogen ligases

Biotin carboxylase

3gid

3gie

DESK_BACSU

O34757

K07778

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-histidine kinases

Histidine kinase

3gie

3gko

URIC_ASPFL

Q00511

K00365

Enzymes

Oxidoreductases

Acting on other nitrogenous compounds as donors

With oxygen as acceptor

Factor-independent urate hydroxylase

3gko

3glv

RIBL_THEVO

Q979C2

KO_id not found

Others

3glv

3gn8

NCOA2_HUMAN

Q15596

KO_id not found

Others

3gn8

3gob

Q5S3I3_STEMA

Q5S3I3

KO_id not found

Others

3gob

3grr

RSMA_METJA

Q58435

K02528

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

16S rRNA (adenine1518-N6-adenine1519-N6)-dimethyltransferase

3grr

3grv

RSMA_METJA

Q58435

K02528

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

16S rRNA (adenine1518-N6-adenine1519-N6)-dimethyltransferase

3grv

3gsi

Q9AGP8_ARTGO

Q9AGP8

KO_id not found

Others

3gsi

3gvi

MDH_BRUA2

Q2YLR9

K00024

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Malate dehydrogenase

3gvi

3gx9

Q51990_PSEPU

Q51990

KO_id not found

Others

3gx9

3gy9

B1YEL6_EXIS2

B1YEL6

KO_id not found

Others

3gy9

3gye

Q4QEW7_LEIMA

Q4QEW7

K00226

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With other, known, acceptors

Dihydroorotate dehydrogenase (fumarate)

3gye

3h0b

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3h0b

3h0w

DCAM_HUMAN

P17707

K01611

Enzymes

Lyases

Carbon-carbon lyases

Carboxy-lyases

Adenosylmethionine decarboxylase

3h0w

3h0z

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3h0z

3h1q

Q3AE93_CARHZ

Q3AE93

KO_id not found

Others

3h1q

3h1v

HXK4_HUMAN

P35557

K12407

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Glucokinase

3h1v

3h23

B1UXN2_BACAN

B1UXN2

KO_id not found

Others

3h23

3h24

B1UXN2_BACAN

B1UXN2

KO_id not found

Others

3h24

3h2a

B1UXN2_BACAN

B1UXN2

KO_id not found

Others

3h2a

3h2n

B1UXN2_BACAN

B1UXN2

KO_id not found

Others

3h2n

3h2y

Q81LQ0_BACAN

Q81LQ0

KO_id not found

Others

3h2y

3h3c

FAK2_HUMAN

Q14289

K05871

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

3h3c

3h3q

C43BP_HUMAN

Q9Y5P4

K08283

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Goodpasture-antigen-binding protein kinase

3h3q

3h3r

C43BP_HUMAN

Q9Y5P4

K08283

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Goodpasture-antigen-binding protein kinase

3h3r

3h4t

P96558_AMYOR

P96558

KO_id not found

Others

3h4t

3h5b

POL_HV1BR

P03367

KO_id not found

Others

3h5b

3h65

HMD_METJA

Q58194

K13942

Enzymes

Oxidoreductases

Acting on hydrogen as donor

With other, known, acceptors

5,10-methenyltetrahydromethanopterin hydrogenase

3h65

3h6l

SETD2_HUMAN

Q9BYW2

K11423

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Histone-lysine N-methyltransferase

3h6l

3h6v

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3h6v

3h9o

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3h9o

3ha6

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3ha6

3hbn

PSEG_CAMJE

Q0P8U5

K15897

Enzymes

Hydrolases

Acting on acid anhydrides

In phosphorus-containing anhydrides

UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase

3hbn

3hdh

HCDH_PIG

P00348

K00022

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

3-hydroxyacyl-CoA dehydrogenase

3hdh

3hfw

ADPRH_HUMAN

P54922

K01245

Enzymes

Hydrolases

Glycosylases

Hydrolysing N-glycosyl compounds

[protein ADP-ribosylarginine] hydrolase

3hfw

3hgy

Q7B8P6_CAMJU

Q7B8P6

KO_id not found

Others

3hgy

3hku

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3hku

3hlj

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3hlj

3hlv

ESR1_HUMAN

P03372

K08550

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A1, ESR1; estrogen receptor alpha

Others

3hlv

3hmi

ABL2_HUMAN

P42684

K08887

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

3hmi

3hnz

FABF_ECOLI

P0AAI5

K09458

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Beta-ketoacyl-acyl-carrier-protein synthase II

3hnz

3ho2

FABF_ECOLI

P0AAI5

K09458

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Beta-ketoacyl-acyl-carrier-protein synthase II

3ho2

3ho9

FABF_ECOLI

P0AAI5

K09458

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Beta-ketoacyl-acyl-carrier-protein synthase II

3ho9

3hs4

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3hs4

3hth

Q79SH7_STRLI

Q79SH7

KO_id not found

Others

3hth

3huc

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3huc

3hv6

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3hv6

3hv7

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3hv7

3hvh

COMT_RAT

P22734

K00545

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Catechol O-methyltransferase

3hvh

3i0r

POL_HV1H2

P04585

KO_id not found

Others

3i0r

3i1l

Q70KP4_9NIDO

Q70KP4

KO_id not found

Others

3i1l

3i28

HYES_HUMAN

P34913

K08726

Enzymes

Hydrolases

Acting on ether bonds

Ether hydrolases

Soluble epoxide hydrolase

3i28

3i4b

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

3i4b

3i52

Q4W2K4_VITVI

Q4W2K4

KO_id not found

Others

3i52

3i6r

PYRD_PLAF7

Q08210

K00254

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With a quinone or related compound as acceptor

Dihydroorotate dehydrogenase (quinone)

3i6r

3i73

VATA_PYRHO

O57728

K02117

Enzymes

Hydrolases

Acting on acid anhydrides

Acting on acid anhydrides to catalyse transmembrane movement of substances

H+-transporting two-sector ATPase

3i73

3i8p

FABF_ECOLI

P0AAI5

K09458

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Beta-ketoacyl-acyl-carrier-protein synthase II

3i8p

3i9l

NADA_APLCA

P29241

K03517

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Quinolinate synthase

3i9l

3iaa

Q8KNE0_MICEC

Q8KNE0

KO_id not found

Others

3iaa

3iad

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

3iad

3iai

CAH9_HUMAN

Q16790

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3iai

3iar

ADA_HUMAN

P00813

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

3iar

3iem

RNSE_THET8

Q5SLP1

KO_id not found

Others

3iem

3iex

Q9BMI9_SCHMA

Q9BMI9

KO_id not found

Others

3iex

3ig7

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3ig7

3igg

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3igg

3ihg

Q54530_9ACTO

Q54530

KO_id not found

Others

3ihg

3ij8

AMYP_HUMAN

P04746

K01176

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Alpha-amylase

3ij8

3ik6

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3ik6

3ilt

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3ilt

3ilu

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3ilu

3in3

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3in3

3in4

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3in4

3inj

ALDH2_HUMAN

P05091

K00128

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

Aldehyde dehydrogenase (NAD+)

3inj

3inn

PANC_BRUME

Q8YFC9

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

3inn

3iob

PANC_MYCTU

P0A5R0

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

3iob

3ioe

PANC_MYCTU

P0A5R0

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

3ioe

3iom

PUNA_MYCTU

P0A538

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3iom

3ioq

Q84XA1_CARCN

Q84XA1

KO_id not found

Others

3ioq

3ip8

AMDA_BORBO

Q05115

KO_id not found

Others

3ip8

3iq7

HASP_HUMAN

Q8TF76

K16315

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3iq7

3itl

Q75WH8_PSEST

Q75WH8

KO_id not found

Others

3itl

3iu9

AMPM2_MYCTU

P0A5J2

K01265

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aminopeptidases

Methionyl aminopeptidase

3iu9

3ivm

Q9X6R4_AERPU

Q9X6R4

KO_id not found

Others

3ivm

3iwj

Q93YB2_PEA

Q93YB2

KO_id not found

Others

3iwj

3jq6

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jq6

3jq7

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jq7

3jq8

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jq8

3jq9

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jq9

3jqa

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jqa

3jqb

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jqb

3jqc

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jqc

3jqd

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jqd

3jqe

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jqe

3jqg

Q581W1_TRYB2

Q581W1

K03793

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Pteridine reductase

3jqg

3jsu

A7UD79_PLAFA

A7UD79

KO_id not found

Others

3jsu

3jsx

NQO1_HUMAN

P15559

K00355

Enzymes

Oxidoreductases

Acting on NADH or NADPH

With a quinone or similar compound as acceptor

NAD(P)H dehydrogenase (quinone)

3jsx

3jtk

NMT1_HUMAN

P30419

K00671

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Glycylpeptide N-tetradecanoyltransferase

3jtk

3k24

CATL1_HUMAN

P07711

K01365

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Cysteine endopeptidases

Cathepsin L

3k24

3k2f

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3k2f

3k31

Q2GKM8_ANAPZ

Q2GKM8

K00208

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With NAD+ or NADP+ as acceptor

Enoyl-[acyl-carrier-protein] reductase (NADH)

3k31

3k3j

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3k3j

3k4l

Q7ZA32_TRAOC

Q7ZA32

KO_id not found

Others

3k4l

3k6b

A4_CAEEL

Q10651

K04520

Heparan sulfate-heparin binding proteins

Others

APP; amyloid beta A4 proteinPlaque formation

Others

3k6b

3k6l

DEF_ECOLI

P0A6K3

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

3k6l

3k73

G3P1_STAAR

Q6GIL8

K00134

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

3k73

3k8q

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3k8q

3k8t

RIR1_YEAST

P21524

K10807

DNA repair and recombination proteins

Eukaryotic Type

Other factors with a suspected DNA repair function

Modulation of nucleotide pools

RRM1; ribonucleoside-diphosphate reductase subunit M1

3k8t

3kb8

C3P9L0_BACAA

C3P9L0

K00760

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Hypoxanthine phosphoribosyltransferase

3kb8

3kdb

POL_HV1BR

P03367

KO_id not found

Others

3kdb

3kdc

POL_HV1BR

P03367

KO_id not found

Others

3kdc

3kdd

POL_HV1BR

P03367

KO_id not found

Others

3kdd

3kfy

DYR_ECOLI

P0ABQ4

K00287

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Dihydrofolate reductase

3kfy

3kgc

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3kgc

3ki3

CHXA_VIBCL

Q5EK40

KO_id not found

Others

3ki3

3ki4

CHXA_VIBCL

Q5EK40

KO_id not found

Others

3ki4

3ki5

CHXA_VIBCL

Q5EK40

KO_id not found

Others

3ki5

3ki6

CHXA_VIBCL

Q5EK40

KO_id not found

Others

3ki6

3kig

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3kig

3kk6

PGH1_SHEEP

P05979

K00509

Enzymes

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

Miscellaneous

Prostaglandin-endoperoxide synthase

3kk6

3km8

ADA_MOUSE

P03958

K01488

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Adenosine deaminase

3km8

3kmc

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3kmc

3kme

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3kme

3kn0

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3kn0

3kne

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3kne

3ko5

Q8IIS0_PLAF7

Q8IIS0

KO_id not found

Others

3ko5

3kti

CLPP_BACSU

P80244

K01358

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Serine endopeptidases

Endopeptidase Clp

3kti

3ku2

Q9BJF5_TOXGO

Q9BJF5

KO_id not found

Others

3ku2

3kzb

Q7NWW7_CHRVO

Q7NWW7

K00854

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Xylulokinase

3kzb

3l03

ESR1_HUMAN

P03372

K08550

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A1, ESR1; estrogen receptor alpha

Others

3l03

3l0v

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3l0v

3l14

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3l14

3l16

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3l16

3l17

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3l17

3l30

PA21B_PIG

P00592

K01047

Enzymes

Hydrolases

Acting on ester bonds

Carboxylic-ester hydrolases

Phospholipase A2

3l30

3l3l

PARP1_HUMAN

P09874

K10798

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

3l3l

3l5c

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3l5c

3l5d

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3l5d

3l5f

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3l5f

3l5r

MIF_HUMAN

P14174

K07253

Enzymes

Isomerases

Intramolecular oxidoreductases

Interconverting keto- and enol-groups

Phenylpyruvate tautomerase

3l5r

3l5u

MIF_HUMAN

P14174

K07253

Enzymes

Isomerases

Intramolecular oxidoreductases

Interconverting keto- and enol-groups

Phenylpyruvate tautomerase

3l5u

3l8w

URIC_ASPFL

Q00511

K00365

Enzymes

Oxidoreductases

Acting on other nitrogenous compounds as donors

With oxygen as acceptor

Factor-independent urate hydroxylase

3l8w

3lal

POL_HV1H2

P04585

KO_id not found

Others

3lal

3lcc

HOL1_ARATH

Q0WP12

KO_id not found

Others

3lcc

3ld4

URIC_ASPFL

Q00511

K00365

Enzymes

Oxidoreductases

Acting on other nitrogenous compounds as donors

With oxygen as acceptor

Factor-independent urate hydroxylase

3ld4

3ldr

Q1W3Z7_ASPJA

Q1W3Z7

KO_id not found

Others

3ldr

3le9

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3le9

3lfb

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3lfb

3lfn

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3lfn

3lfs

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3lfs

3lhh

Q8EDE1_SHEON

Q8EDE1

K03699

Bacterial toxins

Type II toxins- Membrane damaging toxins

Pore-forming toxins, Other

K03699 tlyC; putative hemolysin

Others

3lhh

3lin

Q82134_9DELA

Q82134

KO_id not found

Others

3lin

3lix

Q82134_9DELA

Q82134

KO_id not found

Others

3lix

3ljg

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3ljg

3lk8

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3lk8

3lka

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3lka

3lkh

POLG_HCVJ4

O92972

KO_id not found

Others

3lkh

3lm0

ST17B_HUMAN

O94768

K08804

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3lm0

3lm5

ST17B_HUMAN

O94768

K08804

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3lm5

3lnv

Q5ZTD3_LEGPH

Q5ZTD3

KO_id not found

Others

3lnv

3lu8

ALBU_HUMAN

P02768

KO_id not found

Others

3lu8

3lxe

CAH1_HUMAN

P00915

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3lxe

3lxg

PDE10_RAT

Q9QYJ6

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

3lxg

3lzu

Q9QB59_9HIV1

Q9QB59

KO_id not found

Others

3lzu

3m04

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3m04

3m14

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3m14

3m2p

Q814Z6_BACCR

Q814Z6

KO_id not found

Others

3m2p

3m2w

MAPK2_HUMAN

P49137

K04443

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3m2w

3m2x

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3m2x

3m3l

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3m3l

3m42

MAPK2_HUMAN

P49137

K04443

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3m42

3m67

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3m67

3m7u

PRLA_LYSEN

P00778

KO_id not found

Others

3m7u

3m8q

POL_HV1H2

P04585

KO_id not found

Others

3m8q

3m96

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3m96

3m98

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3m98

3mc5

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

3mc5

3mcv

O76290_TRYBB

O76290

KO_id not found

Others

3mcv

3mcy

Q9S497_ECOLX

Q9S497

KO_id not found

Others

3mcy

3mdz

CAH7_HUMAN

P43166

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3mdz

3mg5

SAV_STRAV

P22629

KO_id not found

Others

3mg5

3mhc

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3mhc

3mhj

TNKS2_HUMAN

Q9H2K2

K10799

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

3mhj

3mhk

TNKS2_HUMAN

Q9H2K2

K10799

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

3mhk

3mjw

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3mjw

3ml5

CAH7_HUMAN

P43166

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3ml5

3ml8

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3ml8

3mnp

GCR_MOUSE

P06537

K05771

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C1, GR; glucocorticoid receptor

Others

3mnp

3ms2

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

3ms2

3ms4

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

3ms4

3msl

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3msl

3mt7

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

3mt7

3mt8

PYGM_RABIT

P00489

K00688

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

Phosphorylase

3mt8

3mtl

CDK16_HUMAN

Q00536

K08820

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3mtl

3myq

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3myq

3mz6

HDAC8_HUMAN

Q9BY41

K11405

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Histone deacetylase

3mz6

3n1s

HINT_ECOLI

P0ACE7

KO_id not found

Others

3n1s

3n2u

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3n2u

3n3i

POL_HV1H2

P04585

KO_id not found

Others

3n3i

3n4k

TRML_YERPE

Q74Y93

K03216

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

TRNA (cytidine34-2'-O)-methyltransferase

3n4k

3n83

ALDH2_HUMAN

P05091

K00128

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

Aldehyde dehydrogenase (NAD+)

3n83

3ncg

A3FQ16_CRYPI

A3FQ16

K13412

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3ncg

3nd1

O68102_RHOCA

O68102

K02228

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Precorrin-6A synthase (deacetylating)

3nd1

3nd7

COAD_ENTFA

Q831P9

K00954

Enzymes

Transferases

Transferring phosphorus-containing groups

Nucleotidyltransferases

Pantetheine-phosphate adenylyltransferase

3nd7

3ndc

COBM_RHOCB

O68100

K05936

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Precorrin-4 C11-methyltransferase

3ndc

3nef

PYL1_ARATH

Q8VZS8

KO_id not found

Others

3nef

3nf6

Q76353_9HIV1

Q76353

KO_id not found

Others

3nf6

3ngn

CNO6L_HUMAN

Q96LI5

KO_id not found

Others

3ngn

3ni5

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3ni5

3njo

PYR1_ARATH

O49686

K11540

Enzymes

Transferases

Transferring one-carbon groups

Carboxy- and carbamoyltransferases

Aspartate carbamoyltransferase

3njo

3nls

POL_HV1BR

P03367

KO_id not found

Others

3nls

3nmh

PYL2_ARATH

O80992

KO_id not found

Others

3nmh

3ns9

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3ns9

3nun

Q9UPJ8_HUMAN

Q9UPJ8

KO_id not found

Others

3nun

3nut

O68097_RHOCA

O68097

K05934

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Precorrin-3B C17-methyltransferase

3nut

3nvw

XDH_BOVIN

P80457

K00106

Enzymes

Oxidoreductases

Acting on CH or CH2 groups

With oxygen as acceptor

Xanthine oxidase

3nvw

3nwb

COMT_RAT

P22734

K00545

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Catechol O-methyltransferase

3nwb

3nxt

DYR_HUMAN

P00374

K00287

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

Dihydrofolate reductase

3nxt

3ny6

CHXA_VIBCL

Q5EK40

KO_id not found

Others

3ny6

3nyn

GRK6_HUMAN

P43250

K08291

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

G-protein-coupled receptor kinase

3nyn

3nzi

HTRA1_HUMAN

Q92743

K08784

Chaperones and folding catalysts

Other chaperones and cochaperones

DegP - HtrA

HTRA1, PRSS11; HtrA serine peptidase 1 Cytoplasm

Others

3nzi

3nzt

Q5NHS8_FRATT

Q5NHS8

K01919

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Glutamate---cysteine ligase

3nzt

3nzu

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3nzu

3o0g

CDK5_HUMAN

Q00535

K02090

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3o0g

3o1x

HINT1_RABIT

P80912

KO_id not found

Others

3o1x

3o56

PDE4B_HUMAN

Q07343

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

3o56

3o64

ADA17_HUMAN

P78536

K06059

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

ADAM 17 endopeptidase

3o64

3o6d

PDXJ_CAMJE

Q9PN59

K03474

Enzymes

Transferases

Transferring nitrogenous groups

Transferring other nitrogenous groups

Pyridoxine 5'-phosphate synthase

3o6d

3o82

B2HVG8_ACIBC

B2HVG8

K02363

Polyketide biosynthesis proteins

Nonribosomal peptide synthetase (NRPS)

Iterative NRPS

Enterobactin synthetase

Peptide arylation enzyme

3o82

405416

3oaw

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3oaw

3od0

KGP1_HUMAN

Q13976

K07376

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

CGMP-dependent protein kinase

3od0

3of1

KAPR_YEAST

P07278

K04739

Others

Organismal Systems

Endocrine system

Insulin signaling pathway

PRKAR; cAMP-dependent protein kinase regulator

3of1

3ogs

Q70SY0_HYPJE

Q70SY0

KO_id not found

Others

3ogs

3ogv

Q70SY0_HYPJE

Q70SY0

KO_id not found

Others

3ogv

3ohl

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

3ohl

3oho

MMP3_HUMAN

P08254

K01394

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Stromelysin 1

3oho

3oik

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3oik

3oil

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3oil

3oix

Q8DVA1_STRMU

Q8DVA1

K00226

Enzymes

Oxidoreductases

Acting on the CH-CH group of donors

With other, known, acceptors

Dihydroorotate dehydrogenase (fumarate)

3oix

3ojl

P95708_STAAU

P95708

KO_id not found

Others

3ojl

3okv

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3okv

3omo

ESR2_HUMAN

Q92731

K08551

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A2, ESR2; estrogen receptor beta

Others

3omo

3omp

ESR2_HUMAN

Q92731

K08551

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A2, ESR2; estrogen receptor beta

Others

3omp

3ooi

NSD1_HUMAN

Q96L73

K15588

Chromosome

Eukaryotic Type

Histone modification proteins

HMTs (histone methyltransferases)

HKMTs (histone lysine methyltransferases)

3ooi

3orf

DHPR_DICDI

Q86A17

K00357

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With NAD+ or NADP+ as acceptor

6,7-dihydropteridine reductase

3orf

3osh

PA2A3_NAJSG

P60045

KO_id not found

Others

3osh

3otg

Q8KNF2_MICEC

Q8KNF2

KO_id not found

Others

3otg

3oti

Q8KND7_MICEC

Q8KND7

KO_id not found

Others

3oti

3ou2

D7PC21_9ACTO

D7PC21

KO_id not found

Others

3ou2

3ou6

D7PC21_9ACTO

D7PC21

KO_id not found

Others

3ou6

3ox1

NQO2_HUMAN

P16083

K08071

Enzymes

Oxidoreductases

Acting on diphenols and related substances as donors

With other acceptors

Ribosyldihydronicotinamide dehydrogenase (quinone)

3ox1

3oxf

SMYD3_HUMAN

Q9H7B4

K11426

Chromosome

Eukaryotic Type

Histone modification proteins

HMTs (histone methyltransferases)

SMYD; SET and MYND domain-containing protein

3oxf

3oy4

POL_HV1A2

P03369

KO_id not found

Others

3oy4

3ozo

Q06GJ0_OSTFU

Q06GJ0

KO_id not found

Others

3ozo

3ozp

Q06GJ0_OSTFU

Q06GJ0

KO_id not found

Others

3ozp

3p0e

UPP2_HUMAN

O95045

K00757

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Uridine phosphorylase

3p0e

3p17

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

3p17

3p1f

CBP_HUMAN

Q92793

K04498

Chromosome

Eukaryotic Type

Histone modification proteins

HATs (histone acetyltransferases)

EP300, CREBBP, KAT3; E1A-CREB-binding protein

3p1f

3p25

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3p25

3p2v

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

3p2v

3p4v

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3p4v

3p86

CTR1_ARATH

Q05609

K14510

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3p86

3pbb

QPCT_HUMAN

Q16769

K00683

Enzymes

Transferases

Acyltransferases

Aminoacyltransferases

Glutaminyl-peptide cyclotransferase

3pbb

3pd5

SYT_PYRAB

Q9UZ14

K01868

Enzymes

Ligases

Forming carbon-oxygen bonds

Ligases forming aminoacyl-tRNA and related compounds

Threonine---tRNA ligase

3pd5

3pdc

HYES_HUMAN

P34913

K08726

Enzymes

Hydrolases

Acting on ether bonds

Ether hydrolases

Soluble epoxide hydrolase

3pdc

3pej

Q8I0V4_PLAF7

Q8I0V4

KO_id not found

Others

3pej

3phb

PNPH_HUMAN

P00491

K03783

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3phb

3pkb

AMPM2_MYCTU

P0A5J2

K01265

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aminopeptidases

Methionyl aminopeptidase

3pkb

3pkc

AMPM2_MYCTU

P0A5J2

K01265

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aminopeptidases

Methionyl aminopeptidase

3pkc

3pkd

AMPM2_MYCTU

P0A5J2

K01265

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aminopeptidases

Methionyl aminopeptidase

3pkd

3pkg

URIC_ASPFL

Q00511

K00365

Enzymes

Oxidoreductases

Acting on other nitrogenous compounds as donors

With oxygen as acceptor

Factor-independent urate hydroxylase

3pkg

3plr

C4XAX5_KLEPN

C4XAX5

K00012

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

UDP-glucose 6-dehydrogenase

3plr

3pm1

QACR_STAAM

P0A0N3

KO_id not found

Others

3pm1

3pn1

DNLJ_HAEIN

P43813

K01972

Enzymes

Ligases

Forming phosphoric-ester bonds

Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

DNA ligase (NAD+)

3pn1

3pn4

DEF1B_ARATH

Q9FUZ2

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

3pn4

3png

NOS1_RAT

P29476

K13240

Enzymes

Oxidoreductases

Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2

With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Nitric-oxide synthase

3png

3pnh

NOS3_BOVIN

P29473

K13242

Enzymes

Oxidoreductases

Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2

With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Nitric-oxide synthase

3pnh

3pnl

DHAK_ECOLI

P76015

K05878

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

3pnl

3po6

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3po6

3po7

AOFB_HUMAN

P27338

K00274

Enzymes

Oxidoreductases

Acting on the CH-NH2 group of donors

With oxygen as acceptor

Monoamine oxidase

3po7

3poo

KAPCA_HUMAN

P17612

K04345

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

CAMP-dependent protein kinase

3poo

3pre

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3pre

3prz

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3prz

3ps6

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3ps6

3ptq

Q01KB2_ORYSA

Q01KB2

KO_id not found

Others

3ptq

3pxy

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3pxy

3pye

ISPE_MYCTU

P65178

K00919

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

3pye

3pz1

PGTA_MOUSE

Q9JHK4

K14050

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Protein geranylgeranyltransferase type II

3pz1

3q2f

BAZ2B_HUMAN

Q9UIF8

KO_id not found

Others

3q2f

3q2m

O06916_LEGPN

O06916

KO_id not found

Others

3q2m

3q4t

AVR2A_HUMAN

P27037

K04670

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Receptor protein serine-threonine kinase

3q4t

3q6w

MET_HUMAN

P08581

K05099

Cellular antigens

Non-CD molecules

MET; met proto-oncogene (hepatocyte growth factor receptor)

Others

3q6w

3q70

CARP2_CANAL

P0DJ06

K06005

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Candidapepsin

3q70

3q71

PAR14_HUMAN

Q460N5

K15261

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

3q71

3qak

AA2AR_HUMAN

P29274

K04266

G protein-coupled receptors

Class A. Rhodopsin family

Base and nucleoside

Adenosine

ADORA2A; adenosine receptor A2a

3qak

3qar

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3qar

3qbc

Q99W87_STAAM

Q99W87

K00950

Enzymes

Transferases

Transferring phosphorus-containing groups

Diphosphotransferases

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

3qbc

3qbw

ANMK_PSEAE

Q9I5Q5

K09001

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Anhydro-N-acetylmuramic acid kinase

3qbw

3qcq

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3qcq

3qcs

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3qcs

3qcx

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3qcx

3qcy

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3qcy

3qd0

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3qd0

3qfv

Q86XZ8_HUMAN

Q86XZ8

K16307

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3qfv

3qfx

DRTS_TRYBB

Q27783

KO_id not found

Others

3qfx

3qgz

HINT1_RABIT

P80912

KO_id not found

Others

3qgz

3qk0

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3qk0

3qp2

D3W065_CHRVL

D3W065

KO_id not found

Others

3qp2

3qqg

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qqg

3qqh

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qqh

3qqj

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qqj

3qqp

DHI1_HUMAN

P28845

K15680

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

11beta-hydroxysteroid dehydrogenase

3qqp

3qrt

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qrt

3qru

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qru

3qsa

TRPD_MYCTU

P66992

K00766

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Anthranilate phosphoribosyltransferase

3qsa

3qui

HFQ_PSEAE

Q9HUM0

KO_id not found

Others

3qui

3qwi

O93874_COCLU

O93874

KO_id not found

Others

3qwi

3qwj

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qwj

3qwk

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qwk

3qx2

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qx2

3qx4

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qx4

3qzf

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qzf

3qzg

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qzg

3qzh

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qzh

3qzi

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3qzi

3r0f

E7E815_9ENTO

E7E815

KO_id not found

Others

3r0f

3r0y

Q000H7_9HIV1

Q000H7

KO_id not found

Others

3r0y

3r1s

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r1s

3r1y

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r1y

3r21

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3r21

3r22

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3r22

3r28

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r28

3r58

AK1C3_HUMAN

P42330

K00089

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

3alpha-hydroxysteroid dehydrogenase (A-specific)

3r58

3r71

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r71

3r73

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r73

3r7o

MET_HUMAN

P08581

K05099

Cellular antigens

Non-CD molecules

MET; met proto-oncogene (hepatocyte growth factor receptor)

Others

3r7o

3r7v

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r7v

3r7y

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r7y

3r83

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r83

3r8l

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r8l

3r8p

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3r8p

3r96

Q47510_ECOLX

Q47510

KO_id not found

Others

3r96

3r9g

Q47510_ECOLX

Q47510

KO_id not found

Others

3r9g

3rdp

KITH_HHV11

P03176

K00857

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Thymidine kinase

3rdp

3rdq

SAV_STRAV

P22629

KO_id not found

Others

3rdq

3rfx

Q7CRQ0_AGRT5

Q7CRQ0

KO_id not found

Others

3rfx

3rga

LSD19_STRLS

B6ZK72

KO_id not found

Others

3rga

3rhx

FGFR1_HUMAN

P11362

K04362

Heparan sulfate-heparin binding proteins

Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis

FGFR1; fibroblast growth factor receptor 1 Mitogenesis

Others

3rhx

3ri1

FGFR2_HUMAN

P21802

K05093

Heparan sulfate-heparin binding proteins

Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis

FGFR2; fibroblast growth factor receptor 2 Mitogenesis

Others

3ri1

3rk0

Q8U2K6_PYRFU

Q8U2K6

KO_id not found

Others

3rk0

3rl7

DLG1_HUMAN

Q12959

KO_id not found

Others

3rl7

3rm7

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3rm7

3roe

NNRE_MOUSE

Q8K4Z3

KO_id not found

Others

3roe

3rog

NNRE_MOUSE

Q8K4Z3

KO_id not found

Others

3rog

3roy

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3roy

3rq4

SV422_HUMAN

Q86Y97

K11429

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Histone-lysine N-methyltransferase

3rq4

3rr4

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

3rr4

3rsv

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3rsv

3rtn

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3rtn

3rts

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3rts

3rtt

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3rtt

3rtu

MMP12_HUMAN

P39900

K01413

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Metalloendopeptidases

Macrophage elastase

3rtu

3rwp

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3rwp

3rwq

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3rwq

3s1d

CKX1_MAIZE

Q9T0N8

K00279

Enzymes

Oxidoreductases

Acting on the CH-NH group of donors

With other acceptors

Cytokinin dehydrogenase

3s1d

3s2a

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3s2a

3s2o

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3s2o

3s2p

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3s2p

3s3g

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

3s3g

3s71

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3s71

3s72

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3s72

3s73

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3s73

3s74

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3s74

3s76

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3s76

3s7l

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

3s7l

3s89

Q8AAN6_BACTN

Q8AAN6

K01912

Enzymes

Ligases

Forming carbon-sulfur bonds

Acid-thiol ligases

Phenylacetate---CoA ligase

3s89

3s9t

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3s9t

3sax

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3sax

3say

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

3say

3sc1

PDPK1_HUMAN

O15530

K06276

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3sc1

3scs

BGL07_ORYSJ

Q75I93

K05350

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Beta-glucosidase

3scs

3shr

KGP1_BOVIN

P00516

K07376

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

CGMP-dependent protein kinase

3shr

3si3

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

3si3

3si4

THRB_HUMAN

P00734

K01313

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F2; coagulation factor II (thrombin)

Others

3si4

3sl8

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

3sl8

3smi

PAR14_HUMAN

Q460N5

K15261

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

3smi

3smj

PAR14_HUMAN

Q460N5

K15261

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

3smj

3soc

AVR2A_HUMAN

P27037

K04670

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Receptor protein serine-threonine kinase

3soc

3sp1

SYC_BORBU

O51545

K01883

Enzymes

Ligases

Forming carbon-oxygen bonds

Ligases forming aminoacyl-tRNA and related compounds

Cysteine---tRNA ligase

3sp1

3spl

APTX_SCHPO

O74859

K10863

DNA repair and recombination proteins

Eukaryotic Type

DSBR (double strand breaks repair)

NHEJ (non-homologous end-joining)

Other NHEJ factors

3spl

3srz

Q189K5_CLOD6

Q189K5

K11063

Bacterial toxins

Type III toxins- Intracellular toxins

Others

Toxin A-B

TcdAB; toxin A-B

3srz

3sxs

BMX_HUMAN

P51813

K08896

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

3sxs

3szl

ISPH_ECOLI

P62623

K03527

Enzymes

Oxidoreductases

Acting on CH or CH2 groups

With NAD+ or NADP+ as acceptor

4-hydroxy-3-methylbut-2-enyl diphosphate reductase

3szl

3t4l

AHK4_ARATH

Q9C5U0

K14489

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-histidine kinases

Histidine kinase

3t4l

3t4n

SNF1_YEAST

P06782

K12761

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3t4n

3t4o

AHK4_ARATH

Q9C5U0

K14489

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-histidine kinases

Histidine kinase

3t4o

3t4s

AHK4_ARATH

Q9C5U0

K14489

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-histidine kinases

Histidine kinase

3t4s

3t4t

AHK4_ARATH

Q9C5U0

K14489

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-histidine kinases

Histidine kinase

3t4t

3t5u

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3t5u

3t5z

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3t5z

3t70

Q8II92_PLAF7

Q8II92

K01520

Enzymes

Hydrolases

Acting on acid anhydrides

In phosphorus-containing anhydrides

DUTP diphosphatase

3t70

3t80

ISPF_SALTY

Q8ZMF7

K01770

Enzymes

Lyases

Phosphorus-oxygen lyases

Phosphorus-oxygen lyases (only sub-subclass identified to date)

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

3t80

3t82

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3t82

3t84

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3t84

3t85

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

3t85

3t94

MTAP_SULSO

Q97W94

K00772

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

S-methyl-5'-thioadenosine phosphorylase

3t94

3t9v

GRIA2_RAT

P19491

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3t9v

3tax

OGT1_HUMAN

O15294

K09667

Enzymes

Transferases

Glycosyltransferases

Hexosyltransferases

3tax

3tb9

RIR1_YEAST

P21524

K10807

DNA repair and recombination proteins

Eukaryotic Type

Other factors with a suspected DNA repair function

Modulation of nucleotide pools

RRM1; ribonucleoside-diphosphate reductase subunit M1

3tb9

3tdh

SNF1_YEAST

P06782

K12761

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3tdh

3te5

SNF1_YEAST

P06782

K12761

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3te5

3tfq

DHI1_HUMAN

P28845

K15680

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

11beta-hydroxysteroid dehydrogenase

3tfq

3tfu

BIOA_MYCTU

P0A4X6

K00833

Enzymes

Transferases

Transferring nitrogenous groups

Transaminases

Adenosylmethionine---8-amino-7-oxononanoate transaminase

3tfu

3thr

GNMT_RAT

P13255

K00552

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Glycine N-methyltransferase

3thr

3tl5

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3tl5

3tlh

POL_HV1B1

P03366

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

3tlh

3tn8

CDK9_HUMAN

P50750

K02211

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3tn8

3tnw

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

3tnw

3tr9

Q83BY6_COXBU

Q83BY6

K00796

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Dihydropteroate synthase

3tr9

3tsd

Q81W29_BACAN

Q81W29

K00088

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

IMP dehydrogenase

3tsd

3tv1

RTCA_ECOLI

P46849

K01974

Enzymes

Ligases

Forming phosphoric-ester bonds

Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

RNA-3'-phosphate cyclase

3tv1

3tyc

Q81VW8_BACAN

Q81VW8

K00796

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Dihydropteroate synthase

3tyc

3tye

Q81VW8_BACAN

Q81VW8

K00796

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Dihydropteroate synthase

3tye

3tyu

Q7CKJ1_YERPE

Q7CKJ1

K00796

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Dihydropteroate synthase

3tyu

3tzm

TGFR1_HUMAN

P36897

K04674

Cytokine receptors

TGF-beta receptors

Type I TGF-beta receptor

TGFBR1; TGF-beta receptor type-1

Others

3tzm

3u04

Q2GI30_EHRCR

Q2GI30

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

3u04

3u2c

ALDR_HUMAN

P15121

K00011

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

Aldehyde reductase

3u2c

3u40

C4LXG4_ENTHI

C4LXG4

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3u40

3u4u

CSK21_HUMAN

P68400

K03097

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3u4u

3u7k

DEF_STAAC

Q5HGZ3

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

3u7k

3u7l

DEF_STAAC

Q5HGZ3

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

3u7l

3u7n

DEF_STAAC

Q5HGZ3

K01462

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In linear amides

Peptide deformylase

3u7n

3ua8

GRIA2_HUMAN

P42262

K05198

Ion Channels

Glutamate-gated cation channels

Glutamate (ionotropic), non-NMDA

GRIA2; glutamate receptor 2

Others

3ua8

3uaw

DEOD_BACCE

Q5EEL8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3uaw

3uay

DEOD_BACCE

Q5EEL8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3uay

3uaz

DEOD_BACCE

Q5EEL8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3uaz

3uel

PARG_RAT

Q9QYM2

K07759

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Poly(ADP-ribose) glycohydrolase

3uel

3uh2

TNKS1_HUMAN

O95271

K10799

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

3uh2

3ujh

B6KMQ4_TOXGO

B6KMQ4

K01810

Enzymes

Isomerases

Intramolecular oxidoreductases

Interconverting aldoses and ketoses, and related compounds

Glucose-6-phosphate isomerase

3ujh

3uk2

PANC_BURTA

Q2T095

K01918

Enzymes

Ligases

Forming carbon-nitrogen bonds

Acid-D-amino-acid ligases (peptide synthases)

Pantoate---beta-alanine ligase

3uk2

3usb

Q81W29_BACAN

Q81W29

K00088

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

IMP dehydrogenase

3usb

3ut6

DEOD_ECOLI

P0ABP8

K03784

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

Purine-nucleoside phosphorylase

3ut6

3uu7

ESR1_HUMAN

P03372

K08550

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A1, ESR1; estrogen receptor alpha

Others

3uu7

3uuc

ESR1_HUMAN

P03372

K08550

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A1, ESR1; estrogen receptor alpha

Others

3uuc

3uwe

AK1C3_HUMAN

P42330

K00089

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

3alpha-hydroxysteroid dehydrogenase (A-specific)

3uwe

3uwp

DOT1L_HUMAN

Q8TEK3

K11427

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Histone-lysine N-methyltransferase

3uwp

3uxj

C3LTF1_VIBCM

C3LTF1

K06879

Enzymes

Oxidoreductases

Acting on other nitrogenous compounds as donors

With NAD+ or NADP+ as acceptor

PreQ1 synthase

3uxj

3v0y

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

3v0y

3v80

PPNK1_LISMO

Q8Y8D7

K00858

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

NAD+ kinase

3v80

3v8m

PPNK1_LISMO

Q8Y8D7

K00858

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

NAD+ kinase

3v8m

3v9b

PDE4D_HUMAN

Q08499

K01120

Enzymes

Hydrolases

Acting on ester bonds

Phosphoric-diester hydrolases

3',5'-cyclic-nucleotide phosphodiesterase

3v9b

3vc4

PIM1_HUMAN

P11309

K04702

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

3vc4

3vd4

BGAL_ECOLI

P00722

K12309

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Beta-galactosidase

3vd4

3vd7

BGAL_ECOLI

P00722

K12309

Enzymes

Hydrolases

Glycosylases

Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Beta-galactosidase

3vd7

3vey

HXK4_HUMAN

P35557

K12407

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Glucokinase

3vey

3vf9

KSYK_HUMAN

P43405

K05855

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

3vf9

3vhv

MCR_HUMAN

P08235

K08555

Nuclear receptors

Estrogen like

C. 3-Ketosteroid receptor

NR3C2, MR; mineralocorticoid receptor

Others

3vhv

3vid

VGFR2_HUMAN

P35968

K05098

Cellular antigens

CD (clusters of differentiation) molecules

CD309; kinase insert domain receptor

Others

3vid

3vqu

TTK_HUMAN

P33981

K08866

Enzymes

Transferases

Transferring phosphorus-containing groups

Dual-specificity kinases (those acting on Ser-Thr and Tyr residues)

Dual-specificity kinase

3vqu

3vrt

VDR_RAT

P13053

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

3vrt

3vru

VDR_RAT

P13053

K08539

Nuclear receptors

Thyroid hormone like

I. Vitamin D3 like receptor

NR1I1, VDR; vitamin D3 receptor

Others

3vru

3vsc

CYSO_AERPE

Q9YBL2

K10150

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Cysteine synthase

3vsc

3zrm

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

3zrm

3zs5

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

3zs5

3ztc

ELOB_HUMAN

Q15370

K03873

DNA repair and recombination proteins

Eukaryotic Type

SSBR (single strand breaks repair)

NER (nucleotide excision repair)

TCEB2; transcription elongation factor B, polypeptide 2

3ztc

3zw3

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

3zw3

3zwx

NADA_APLCA

P29241

K03517

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Quinolinate synthase

3zwx

3zzn

LDH_THET8

Q5SJA1

K00016

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

L-lactate dehydrogenase

3zzn

4a0m

BADH_SPIOL

P17202

K00130

Enzymes

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD+ or NADP+ as acceptor

Betaine-aldehyde dehydrogenase

4a0m

4a16

ACES_MOUSE

P21836

K01049

Enzymes

Hydrolases

Acting on ester bonds

Carboxylic-ester hydrolases

Acetylcholinesterase

4a16

4a7i

FA10_HUMAN

P00742

K01314

Heparan sulfate-heparin binding proteins

Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control

F10; coagulation factor X

Others

4a7i

4aa0

MK14_HUMAN

Q16539

K04441

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

4aa0

4acc

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

4acc

4acg

GSK3B_HUMAN

P49841

K03083

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Tau-protein kinase

4acg

4acm

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

4acm

4af3

AURKB_HUMAN

Q96GD4

K11479

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

4af3

4aic

DXR_MYCTU

P64012

K00099

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

1-deoxy-D-xylulose-5-phosphate reductoisomerase

4aic

4aiu

OGA_BACTN

Q89ZI2

K01197

Heparan sulfate-heparin binding proteins

Enzymes(General comment) Variety

Hya; hyaluronoglucosaminidase

Others

4aiu

4ajw

PK3CD_MOUSE

O35904

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

4ajw

4anx

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

4anx

4at5

NTRK2_HUMAN

Q16620

K04360

Cytokine receptors

Receptor tyrosine kinase

RTK class VII (TRK receptor family)

NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2

Others

4at5

4avu

TNKS2_HUMAN

Q9H2K2

K10799

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

4avu

4avw

TNKS2_HUMAN

Q9H2K2

K10799

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

NAD+ ADP-ribosyltransferase

4avw

4aw5

EPHB4_HUMAN

P54760

K05113

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Receptor protein-tyrosine kinase

4aw5

4dbs

AK1C3_HUMAN

P42330

K00089

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

3alpha-hydroxysteroid dehydrogenase (A-specific)

4dbs

4dch

HXK4_HUMAN

P35557

K12407

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Glucokinase

4dch

4dfn

KSYK_HUMAN

P43405

K05855

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

4dfn

4dhf

AURKA_HUMAN

O14965

K11481

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

4dhf

4djy

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

4djy

4dma

ESR1_HUMAN

P03372

K08550

Nuclear receptors

Estrogen like

A. Estrogen receptor

NR3A1, ESR1; estrogen receptor alpha

Others

4dma

4drq

FKBP5_HUMAN

Q13451

K09571

Enzymes

Isomerases

Cis-trans-Isomerases

Cis-trans Isomerases (only sub-subclass identified to date)

Peptidylprolyl isomerase

4drq

4dz3

Q3JK38_BURP1

Q3JK38

K01802

Enzymes

Isomerases

Cis-trans-Isomerases

Cis-trans Isomerases (only sub-subclass identified to date)

Peptidylprolyl isomerase

4dz3

4e3f

CAH2_HUMAN

P00918

K01672

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

Carbonate dehydratase

4e3f

4eg2

CDD_VIBCH

Q9KSM5

K01489

Enzymes

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Cytidine deaminase

4eg2

4egb

Q81TP0_BACAN

Q81TP0

K01710

Enzymes

Lyases

Carbon-oxygen lyases

Hydro-lyases

DTDP-glucose 4,6-dehydratase

4egb

4ei4

JAK1_HUMAN

P23458

K11217

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-tyrosine kinases

Non-specific protein-tyrosine kinase

4ei4

4emd

B1MKD5_MYCA9

B1MKD5

K00919

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

4emd

4eqz

DOT1L_HUMAN

Q8TEK3

K11427

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Histone-lysine N-methyltransferase

4eqz

4er3

DOT1L_HUMAN

Q8TEK3

K11427

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

Histone-lysine N-methyltransferase

4er3

4erk

MK01_RAT

P63086

K04371

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase

4erk

4ez3

CDK2_HUMAN

P24941

K02206

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Cyclin-dependent kinase

4ez3

4f0r

Q7NZ90_CHRVO

Q7NZ90

K05394

Enzymes

Hydrolases

Acting on halide bonds

In carbon-halide compounds

Atrazine chlorohydrolase

4f0r

4f0s

Q7NZ90_CHRVO

Q7NZ90

K05394

Enzymes

Hydrolases

Acting on halide bonds

In carbon-halide compounds

Atrazine chlorohydrolase

4f0s

4f1s

PK3CG_HUMAN

P48736

K00922

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Phosphatidylinositol-4,5-bisphosphate 3-kinase

4f1s

4f2d

ARAA_ECOLI

P08202

K01804

Enzymes

Isomerases

Intramolecular oxidoreductases

Interconverting aldoses and ketoses, and related compounds

L-arabinose isomerase

4f2d

4f32

A4JL30_BURVG

A4JL30

K09458

Enzymes

Transferases

Acyltransferases

Transferring groups other than aminoacyl groups

Beta-ketoacyl-acyl-carrier-protein synthase II

4f32

4fak

RLMH_STAAU

P0C1V0

K00783

Enzymes

Transferases

Transferring one-carbon groups

Methyltransferases

23S rRNA (pseudouridine1915-N3)-methyltransferase

4fak

4fev

B0VD92_ACIBY

B0VD92

K00897

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Kanamycin kinase

4fev

4few

B0VD92_ACIBY

B0VD92

K00897

Enzymes

Transferases

Transferring phosphorus-containing groups

Phosphotransferases with an alcohol group as acceptor

Kanamycin kinase

4few

4fgc

QUEF_BACSU

O31678

K09457

Enzymes

Oxidoreductases

Acting on other nitrogenous compounds as donors

With NAD+ or NADP+ as acceptor

PreQ1 synthase

4fgc

4fhd

A4IQU1_GEOTN

A4IQU1

K03716

Enzymes

Lyases

Carbon-carbon lyases

Other carbon-carbon lyases

Spore photoproduct lyase

4fhd

4fo4

Q9KTW3_VIBCH

Q9KTW3

K00088

Enzymes

Oxidoreductases

Acting on the CH-OH group of donors

With NAD+ or NADP+ as acceptor

IMP dehydrogenase

4fo4

4frs

BACE1_HUMAN

P56817

K04521

Enzymes

Hydrolases

Acting on peptide bonds (peptidases)

Aspartic endopeptidases

Memapsin 2

4frs

4fsw

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

4fsw

4fsy

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

4fsy

4fsz

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

4fsz

4ft9

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

4ft9

4ftt

CHK1_HUMAN

O14757

K02216

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Non-specific serine-threonine protein kinase

4ftt

4g3e

M3K14_MOUSE

Q9WUL6

K04466

Enzymes

Transferases

Transferring phosphorus-containing groups

Protein-serine-threonine kinases

Mitogen-activated protein kinase kinase kinase

4g3e

4g55

CLH1_HUMAN

Q00610

K08099

Enzymes

Hydrolases

Acting on ester bonds

Carboxylic-ester hydrolases

Chlorophyllase

4g55

4gcx

TGT_ZYMMO

P28720

K00773

Enzymes

Transferases

Glycosyltransferases

Pentosyltransferases

TRNA-guanine transglycosylase

4gcx

4gef

Q6FXA8_CANGA

Q6FXA8

K00794

Enzymes

Transferases

Transferring alkyl or aryl groups, other than methyl groups

Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

6,7-dimethyl-8-ribityllumazine synthase

4gef

6cox

PGH2_MOUSE

Q05769

K11987

Enzymes

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

Miscellaneous

Prostaglandin-endoperoxide synthase

6cox

7upj

POL_HV1BR

P03367

KO_id not found

Enzymes

3. Hydrolases

proteases (aspartic)

protease (HIV-1)

Others

7upj