pharmacophore.Pharma-ID pharmacophore/metadata/Gene-Name pharmacophore/metadata/Uniprot-AC pharmacophore/metadata/Kegg-Identifier pharmacophore/metadata/Target-Class pharmacophore/metadata/Target-Class-A pharmacophore/metadata/Target-Class-B pharmacophore/metadata/Target-Class-C pharmacophore/metadata/Target-Class-D pharmacophore/metadata/pdb.complex_id pharmacophore/metadata/Taxonomic-ID pharmacophore.name pharmacophore.selectivity_index pharmacophore/metadata/drug-classification pharmacophore/metadata/target pharmacophore/metadata/target-subclass pharmacophore/metadata/target-family pharmacophore/metadata/target-acronym pharmacophore/metadata/therapeutic-classification pharmacophore/metadata/mode-of-action pharmacophore/metadata/pdb.ligand_id pharmacophore/metadata/pdb.resolution pharmacophore/actives/molecule.name pharmacophore/actives/molecule.smiles pharmacophore/actives/molecule.registry pharmacophore/actives/molecule.regtype pharmacophore/bibliography/reference.title pharmacophore/bibliography/reference.author pharmacophore/bibliography/reference.source pharmacophore/bibliography/reference.year pharmacophore/bibliography/reference.doi
1a42 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 1a42                                          
1afq CTRA_BOVIN P00766 KO_id not found Others Others Others Others Others 1afq                                          
1agw FGFR1_HUMAN P11362 K04362 Heparan sulfate-heparin binding proteins Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis FGFR1; fibroblast growth factor receptor 1 Mitogenesis Others Others 1agw                                          
1ah3 ALDR_PIG P80276 K00011 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Aldehyde reductase 1ah3                                          
1aqb RET4_PIG P27485 KO_id not found Others Others Others Others Others 1aqb                                          
1b3d MMP3_HUMAN P08254 K01394 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Stromelysin 1 1b3d                                          
1bmk MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 1bmk                                          
1byg CSK_HUMAN P41240 K05728 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 1byg                                          
1bzs MMP8_HUMAN P22894 K01402 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Neutrophil collagenase 1bzs                                          
1c1c POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1c1c                                          
1cg6 MTAP_HUMAN Q13126 K00772 Enzymes Transferases Glycosyltransferases Pentosyltransferases S-methyl-5'-thioadenosine phosphorylase 1cg6                                          
1coy CHOD_BREST P22637 K10078 (inferred by homologyHUMAN) Glycan Binding Proteins C-Type lectin Group 8 Layilin and related receptors CHODL; chondrolectin Cholesterol oxidase 1coy 1702                                        
1crb RET1_RAT P02696 KO_id not found Others Others Others Others Others 1crb                                          
1d2s SHBG_HUMAN P04278 KO_id not found Others Others Others Others Others 1d2s                                          
1d3d THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 1d3d                                          
1d7o FABI_BRANA P80030 K00208 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor Enoyl-[acyl-carrier-protein] reductase (NADH) 1d7o                                          
1d7u DGDA_BURCE P16932 KO_id not found Enzymes 4. Lyases decarboxylases DGD (bacterial) Others 1d7u                                          
1d7x MMP3_HUMAN P08254 K01394 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Stromelysin 1 1d7x                                          
1dht DHB1_HUMAN P14061 K00044 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Estradiol 17beta-dehydrogenase 1dht                                          
1di8 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 1di8                                          
1di9 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 1di9                                          
1e3k PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 1e3k                                          
1e3v SDIS_PSEPU P07445 KO_id not found Enzymes 5. Isomerases steroid delta-isomerases KSI (bacterial) Others 1e3v                                          
        Enzymes         1e9h   1e9h-inr-2.5-h-1-s 929 oncolytic cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase
EC2.- (transferases) kinases (serine-threonine) CDK2 cancer
cardiovascular diseases
viral infection
modulation of cell division, inhibition of signal transduction pathways inr 2.50 244021-67-8 OS(=O)(=O)c1ccc2NC(=O)/C(=C/3\Nc4ccccc4C3=O)/c2c1 244021-67-8 CAS Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble ME Structure (Camb) 9(5):389-97 2001 10.1016/S0969-2126(01)00598-6
        Enzymes         1e9h   1e9h-inr-2.50-h-1-s 1.50037 oncolytic cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase
EC2.- (transferases) kinases (serine-threonine) CDK2 cancer
cardiovascular diseases
viral infection
inhibition (enzyme); competitive inr 2.50 478283-10-2 [C=1C=CC2=C(C1)C(=O)\C(=C\3/C=4C=C(C=CC4NC3=O)S(=O)(=O)O)\N2] 478283-10-2 CAS Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble ME. Structure 9(5):389-97 2001 10.1016/S0969-2126(01)00598-6
        Enzymes         1e9h   1e9h-inr-2.50-h-1 10.07159 oncolytic cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase
EC2.- (transferases) kinases (serine-threonine) CDK2 cancer
cardiovascular diseases
viral infection
inhibition (enzyme); competitive inr 2.50 478283-10-2 [C=1C=CC2=C(C1)C(=O)\C(=C\3/C=4C=C(C=CC4NC3=O)S(=O)(=O)O)\N2] 478283-10-2 CAS Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble ME. Structure 9(5):389-97 2001 10.1016/S0969-2126(01)00598-6
1efy PARP1_CHICK P26446 K10798 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 1efy                                          
1erb RET4_BOVIN P18902 KO_id not found Others Others Others Others Others 1erb                                          
1f4e TYSY_ECOLI P0A884 K00560 Enzymes Transferases Transferring one-carbon groups Methyltransferases Thymidylate synthase 1f4e                                          
1fgi FGFR1_HUMAN P11362 K04362 Heparan sulfate-heparin binding proteins Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis FGFR1; fibroblast growth factor receptor 1 Mitogenesis Others Others 1fgi                                          
        Enzymes         1fk9   1fk9-efz-2.50-d-1-s 194 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 2.50 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase Ren J, Milton J, Weaver KL, Short SA, Stuart DI, Stammers DK Structure Fold Des 8(10):1089-94 2000 10.1016/S0969-2126(00)00513-X
        Enzymes         1fk9   1fk9-efz-2.50-d-1 1314 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 2.50 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase Ren J, Milton J, Weaver KL, Short SA, Stuart DI, Stammers DK Structure Fold Des 8(10):1089-94 2000 10.1016/S0969-2126(00)00513-X
1fk9 POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1fk9                                          
1fkh FKB1A_HUMAN P62942 K09568 Enzymes Isomerases Cis-trans-Isomerases Cis-trans Isomerases (only sub-subclass identified to date) Peptidylprolyl isomerase 1fkh                                          
        Enzymes         1fko   1fko-efz-2.90-d-1-s 201 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 2.90 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase Ren J, Milton J, Weaver KL, Short SA, Stuart DI, Stammers DK Structure Fold Des 8(10):1089-94 2000 10.1016/S0969-2126(00)00513-X
        Enzymes         1fko   1fko-efz-2.90-d-1 1425 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 2.90 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase Ren J, Milton J, Weaver KL, Short SA, Stuart DI, Stammers DK Structure Fold Des 8(10):1089-94 2000 10.1016/S0969-2126(00)00513-X
1fm7 CFI1_MEDSA P28012 K01859 Enzymes Isomerases Intramolecular lyases Intramolecular lyases (only sub-subclass identified to date) Chalcone isomerase 1fm7                                          
1fvv CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 1fvv                                          
1gg5 NQO1_HUMAN P15559 K00355 Enzymes Oxidoreductases Acting on NADH or NADPH With a quinone or similar compound as acceptor NAD(P)H dehydrogenase (quinone) 1gg5                                          
1gii CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 1gii                                          
1gx8 LACB_BOVIN P02754 KO_id not found Others Others Others Others Others 1gx8                                          
1h69 NQO1_HUMAN P15559 K00355 Enzymes Oxidoreductases Acting on NADH or NADPH With a quinone or similar compound as acceptor NAD(P)H dehydrogenase (quinone) 1h69                                          
        Transport proteins         1h9z   1h9z-rwf-2.50-h-1 13576 immunologic Serum albumin extracellular proteins serum proteins HSA inflammation Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. rwf 2.50 (S)-Warfarin CC(=O)C[C@H](c1ccccc1)c2c(O)c3ccccc3oc2=O 5543-57-7 CAS Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I Petitpas I, Bhattacharya AA, Twine S, East M, Curry S J Biol Chem 276(25):22804-9 2001 10.1074/jbc.M100575200
        Transport proteins         1ha2   1ha2-swf-2.50-h-1 12247 immunologic Serum albumin extracellular proteins serum proteins HSA inflammation Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. swf 2.50 (R)-Warfarin CC(=O)C[C@@H](c1ccccc1)c2c(O)c3ccccc3oc2=O 5543-58-8 CAS Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I Petitpas I, Bhattacharya AA, Twine S, East M, Curry S J Biol Chem 276(25):22804-9 2001 10.1074/jbc.M100575200
1he3 BLVRB_HUMAN P30043 K05901 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor Biliverdin reductase 1he3                                          
        Enzymes         1hnv   1hnv-tbo-3.00-d-1-s 2541 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
tbo 3.00 tivirapine C[C@H]1Cn2c(=S)[nH]c3ccc(Cl)c(CN1CC=C(C)C)c23 137332-54-8 cas Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution Ding J, Das K, Tantillo C, Zhang W, Clark AD Jr, Jessen S, Lu X, Hsiou Y, Jacobo-Molina A, Andries K, et al. Structure 3(4):365-79 1995 10.1016/S0969-2126(01)00168-X
1hpz POL_HV1B1 P03366 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1hpz                                          
        Structuring proteins         1hrv   1hrv-sdz-3.00-d-2-s 598 antiinfective HRV coat protein Cellular level viral coat proteins VP1-4 (HRV) common cold inhibition of viral entry into host cell and/or uncoating
occupation of a hydrophobic pocket and consequent stabilisation of viral capsid
sdz 3.00 INT-SDZ 35-682-art-1-d O[C@H](COc1ccc(cc1)C2CCCCC2)CN3CCN(CC3)c4ccccn4 INT-SDZ 35-682-art-1-d INT SDZ 35-682, a new picornavirus capsid-binding agent with potent antiviral activity Rosenwirth B, Oren DA, Arnold E, Kis ZL, Eggers HJ Antiviral Res 26(1):65-82 1995 10.1016/0166-3542(94)00066-H
1hzx OPSD_BOVIN P02699 K04250 G protein-coupled receptors Class A. Rhodopsin family Vision Opsin RHO, OPN2; rhodopsin 1hzx                                          
        Enzymes         1i2z   1i2z-654-2.80-d-1-s 2.03430276 antiinfective bacterial enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (e.coli) bacterial infection inhibition of final step in bacterial fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in bacteria
654 2.80 310465-11-3 Cc3ccc(Cn2cnc(c1cccs1)c2)cc3 310465-11-3 cas 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF Bioorg Med Chem Lett 11(16):2061-5 2001 10.1016/S0960-894X(01)00404-8
1i38 ANDR_RAT P15207 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 1i38                                          
1i7i PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 1i7i                                          
1i8z CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 1i8z                                          
1i90 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 1i90                                          
1if9 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 1if9                                          
1iiu RET4_CHICK P41263 KO_id not found Others Others Others Others Others 1iiu                                          
1ij8 AVID_CHICK P02701 KO_id not found Others Others Others Others Others 1ij8                                          
        Enzymes         1ikv   1ikv-efz-3.00-d-1-s 1202 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 3.00 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant Lindberg J, Sigurdsson S, Lowgren S, Andersson HO, Sahlberg C, Noreen R, Fridborg K, Zhang H, Unge T Eur J Biochem 269(6):1670-7 2002 10.1046/j.1432-1327.2002.02811.x
        Enzymes         1ikw   1ikw-efz-3.00-d-1-s 1148 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 3.00 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant Lindberg J, Sigurdsson S, Lowgren S, Andersson HO, Sahlberg C, Noreen R, Fridborg K, Zhang H, Unge T Eur J Biochem 269(6):1670-7 2002 10.1046/j.1432-1327.2002.02811.x
1iky POL_HV1B1 P03366 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1iky                                          
1iqh FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 1iqh                                          
1iqj FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 1iqj                                          
1j4i FKB1A_HUMAN P62942 K09568 Enzymes Isomerases Cis-trans-Isomerases Cis-trans Isomerases (only sub-subclass identified to date) Peptidylprolyl isomerase 1j4i                                          
1jg0 TYSY_ECOLI P0A884 K00560 Enzymes Transferases Transferring one-carbon groups Methyltransferases Thymidylate synthase 1jg0                                          
1jiz MMP12_HUMAN P39900 K01413 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Macrophage elastase 1jiz                                          
        Enzymes         1jkh   1jkh-efz-2.50-d-1-s 192 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 2.50 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors Ren J, Nichols C, Bird L, Chamberlain P, Weaver K, Short S, Stuart DI, Stammers DK J Mol Biol 312(4):795-805 2001 10.1006/jmbi.2001.4988
        Enzymes         1jkh   1jkh-efz-2.50-d-1 1360 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
efz 2.50 efavirenz FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc21)C#CC3CC3 154598-52-4 cas Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors Ren J, Nichols C, Bird L, Chamberlain P, Weaver K, Short S, Stuart DI, Stammers DK J Mol Biol 312(4):795-805 2001 10.1006/jmbi.2001.4988
1jla POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1jla                                          
        Enzymes         1jlq   1jlq-sbn-3.00-d-1-s 1274 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
sbn 3.00 739W94 Cc1cc(C)cc(c1)S(=O)(=O)c2cccc(N)c2C#N 171102-55-9 cas 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1 Chan JH, Hong JS, Hunter RN 3rd, Orr GF, Cowan JR, Sherman DB, Sparks SM, Reitter BE, Andrews CW 3rd, Hazen RJ, St Clair M, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Ott RJ, Ren J, Hopkins A, Stuart DI, Stammers DK J Med Chem 44(12):1866-82 2001 10.1021/jm0004906
1jlq POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1jlq                                          
1jtv DHB1_HUMAN P14061 K00044 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Estradiol 17beta-dehydrogenase 1jtv                                          
1kbq NQO1_HUMAN P15559 K00355 Enzymes Oxidoreductases Acting on NADH or NADPH With a quinone or similar compound as acceptor NAD(P)H dehydrogenase (quinone) 1kbq                                          
1kgj TTHY_RAT P02767 KO_id not found Others Others Others Others Others 1kgj                                          
1klm POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 1klm                                          
1kqw Q8UVG6_DANRE Q8UVG6 KO_id not found Others Others Others Others Others 1kqw                                          
1kt6 RET4_BOVIN P18902 KO_id not found Others Others Others Others Others 1kt6                                          
1l2s AMPC_ECOLI P00811 K01467 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In cyclic amides Beta-lactamase 1l2s                                          
1lhv SHBG_HUMAN P04278 KO_id not found Others Others Others Others Others 1lhv                                          
1lkd BPHC_BURXL P47228 K00462 Enzymes Oxidoreductases Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2 With incorporation of two atoms of oxygen Biphenyl-2,3-diol 1,2-dioxygenase 1lkd                                          
1lox LOX15_RABIT P12530 K00460 Enzymes Oxidoreductases Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2 With incorporation of two atoms of oxygen Arachidonate 15-lipoxygenase 1lox                                          
        Enzymes         1lxc   1lxc-aym-2.40-d-1-s 1.70618941 antiinfective bacterial enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (e.coli) bacterial infection inhibition of final step in bacterial fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in bacteria
aym 2.40 335027-53-7 CN(Cc2cc1ccccc1n2C)C(=O)C=Cc3ccc(N)nc3 335027-53-7 cas Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI) Miller WH, Seefeld MA, Newlander KA, Uzinskas IN, Burgess WJ, Heerding DA, Yuan CC, Head MS, Payne DJ, Rittenhouse SF, Moore TD, Pearson SC, Berry V, DeWolf WE Jr, Keller PM, Polizzi BJ, Qiu X, Janson CA, Huffman WF J Med Chem 45(15):3246-56 2002 10.1021/jm020050+
1m2r CSK2A_MAIZE P28523 KO_id not found Others Others Others Others Others 1m2r                                          
        Enzymes         1mfp   1mfp-idn-2.33-d-1-s 0.98881432 antiinfective bacterial enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (e.coli) bacterial infection inhibition of final step in bacterial fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in bacteria
idn 2.33 335029-32-8 CN(Cc1cn(C)c2ccccc12)C(=O)C=Cc4c[nH]c3=NC(=O)CCc3c4 335029-32-8 cas Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK Seefeld MA, Miller WH, Newlander KA, Burgess WJ, DeWolf WE Jr, Elkins PA, Head MS, Jakas DR, Janson CA, Keller PM, Manley PJ, Moore TD, Payne DJ, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Uzinskas IN, Wallis NG, Huffman WF J Med Chem 46(9):1627-35 2003 10.1021/jm0204035
1nfw FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 1nfw                                          
        Enzymes         1nfx   1nfx-rdr-2.15-h-1 1481 Cardiovascular disease coagulation factor Xa
Factor Xa
Fxa
activated coagulation factor X
EC3.- (hydrolases) proteases (serine) FXa cardiovascular diseases
thrombosis
no info rdr 2.15 RPR 208944 OCCn1c(CN2CCN(CC2=O)S(=O)(=O)c3cc4ccc(Cl)cc4s3)cc5cnccc15 234100-47-1 CAS Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket Maignan S, Guilloteau JP, Choi-Sledeski YM, Becker MR, Ewing WR, Pauls HW, Spada AP, Mikol V J Med Chem 46(5):685-90. 2003 10.1021/jm0203837
1nfx FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 1nfx                                          
1nhg Q9BH77_PLAFA Q9BH77 KO_id not found Enzymes 1. Oxidoreductases CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) Others 1nhg                                          
1nhw Q9BH77_PLAFA Q9BH77 KO_id not found Enzymes 1. Oxidoreductases CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) Others 1nhw                                          
1nhz GCR_HUMAN P04150 K05771 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C1, GR; glucocorticoid receptor Others 1nhz                                          
1nlu PICP_PSESR P42790 KO_id not found Others Others Others Others Others 1nlu                                          
        Enzymes         1nnu   1nnu-tct-2.50-d-1 0.36241611 antiinfective parasitic enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) malaria
parasitic infection
inhibition of final step in parasitic fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in parasites
tct 2.50 434320-70-4 Oc3ccc2cc(Oc1cc(Cl)ccc1O)ccc2c3 434320-70-4 cas Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase Perozzo R, Kuo M, Sidhu AS, Valiyaveettil JT, Bittman R, Jacobs WR Jr, Fidock DA, Sacchettini JC J Biol Chem 277(15):13106-14 2002 10.1074/jbc.M112000200
1nup NMNA3_HUMAN Q96T66 K06210 Enzymes Transferases Transferring phosphorus-containing groups Nucleotidyltransferases Nicotinamide-nucleotide adenylyltransferase 1nup                                          
1nwk ACTS_RABIT P68135 K10354 Others Eukaryotic cytoskeleton proteins Actin filaments - Microfilaments Actins Actins 1nwk                                          
        Receptors         1nyx   1nyx-drf-2.65-p-1-s 1597 metabolic peroxisome proliferator-activated receptor gamma Transduction factor receptors nuclear hormone receptors PPAR-gamma obesity activation of peroxisome proliferator-activated receptor gamma
central regulator of adipocyte differentiation, fatty acid metabolism and glucose homeostasis; inhibition of inflammatory cytokines and other proteins
drf 2.65 ragaglitazar CCO[C@@H](Cc1ccc(OCCN2c3ccccc3Oc4ccccc24)cc1)C(=O)O 222834-30-2 CAS Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar Ebdrup S, Pettersson I, Rasmussen HB, Deussen HJ, Frost Jensen A, Mortensen SB, Fleckner J, Pridal L, Nygaard L, Sauerberg P J. Med. Chem 46, 1306-1317 2003 10.1021/jm021027r
        Receptors         1nyx   1nyx-drf-2.65-p-1 2109 metabolic peroxisome proliferator-activated receptor gamma Transduction factor receptors nuclear hormone receptors PPAR-gamma obesity activation of peroxisome proliferator-activated receptor gamma
central regulator of adipocyte differentiation, fatty acid metabolism and glucose homeostasis; inhibition of inflammatory cytokines and other proteins
drf 2.65 ragaglitazar CCO[C@@H](Cc1ccc(OCCN2c3ccccc3Oc4ccccc24)cc1)C(=O)O 222834-30-2 CAS Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar Ebdrup S, Pettersson I, Rasmussen HB, Deussen HJ, Frost Jensen A, Mortensen SB, Fleckner J, Pridal L, Nygaard L, Sauerberg P J. Med. Chem 46, 1306-1317 2003 10.1021/jm021027r
1nyx PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 1nyx                                          
        Enzymes         1ogx   1ogx-equ-2.00-d-1-s 1284 antiinfective bacterial steroid delta-isomerase EC5.- (isomerases) steroid delta-isomerases KSI (bacterial) fundamental research
bacterial infection
inhibition of bacterial steroid delta-isomerase
prevention of cleavage and formation of a C-H bond for steroid substrates
eqn 2.00 equilenin C[C@@]12CCc3c(ccc4cc(O)ccc34)[C@@H]2CCC1=O 517-09-9 CAS Detection of large pKa perturbations of an inhibitor and a catalytic group at an enzyme active site, a mechanistic basis for catalytic power of many enzymes Ha NC, Kim MS, Lee W, Choi KY, Oh BH J Biol Chem 275(52):41100-6 2000 10.1074/jbc.M007561200
1opb RET2_RAT P06768 KO_id not found Others Others Others Others Others 1opb                                          
        Receptors         1osh   1osh-fex-1.78-d-1 2.5891126 metabolic, anti-target farnesoid x receptor Transduction factor receptors nuclear hormone receptors FXR ADMET
bile acid-induced hepatotoxicity
Lowers bile-acid plasma levels via the repression of the transcription of the cholesterol 7-alpha-hydroxylase gene (P450 7A1) and the P450 8B gene via the inhibitory nuclear receptor SHP (inhibition of bile-acid biosynthesis from cholesterol) and activates the intestinal bile acid-binding protein (IBABP). fex 1.78 fexaramine CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C=3C=CC=C(C3)C=CC(=O)OC)C(=O)C4CCCCC4 574013-66-4 cas A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM Mol Cell 11(4):1079-92 2003 10.1016/S1097-2765(03)00104-7
1oum DEOD_ECOLI P0ABP8 K03784 Enzymes Transferases Glycosyltransferases Pentosyltransferases Purine-nucleoside phosphorylase 1oum                                          
1ov6 DEOD_ECOLI P0ABP8 K03784 Enzymes Transferases Glycosyltransferases Pentosyltransferases Purine-nucleoside phosphorylase 1ov6                                          
1ovg DEOD_ECOLI P0ABP8 K03784 Enzymes Transferases Glycosyltransferases Pentosyltransferases Purine-nucleoside phosphorylase 1ovg                                          
1oxl PA2B8_DABRR P59071 KO_id not found Others Others Others Others Others 1oxl                                          
1pxl CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 1pxl                                          
1pxx PGH2_MOUSE Q05769 K11987 Enzymes Oxidoreductases Acting on paired donors with incorporation of molecular oxygen Miscellaneous Prostaglandin-endoperoxide synthase 1pxx                                          
1py5 TGFR1_HUMAN P36897 K04674 Cytokine receptors TGF-beta receptors Type I TGF-beta receptor TGFBR1; TGF-beta receptor type-1 Others 1py5                                          
        Enzymes         1pye   1pye-pm1-2.00-h-1-s 773 oncolytic cyclin-dependent kinase 2
CDK 2
cell division protein kinase 2
SIN3-associated protein
SIN3 associated polypeptide
p33 protein kinase
EC2.- (transferases) kinases (serine-threonine) CDK2 cancer
cardiovascular diseases
viral infection
modulation of cell division, inhibition of signal transduction pathways pm1 2.00 490038-61-4 Nc1nc2ccc(cn2c1C(=O)c3ccccc3)C(=O)c4c(F)cccc4F 490038-61-4 CAS The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines Hamdouchi C, Keyser H, Collins E, Jaramillo C, De Diego JE, Spencer CD, Dempsey JA, Anderson BD, Leggett T, Stamm NB, Schultz RM, Watkins SA, Cocke K, Lemke S, Burke TF, Beckmann RP, Dixon JT, Gurganus TM, Rankl NB, Houck KA, Zhang F, Vieth M, Espinosa J, Timm DE, Campbell RM, Patel BK, Brooks HB Mol Cancer Ther 3(1):1-9 2004  
1pye CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 1pye                                          
1pzo BLAT_ECOLX P62593 KO_id not found Others Others Others Others Others 1pzo                                          
1q23 CAT_ECOLX P62577 KO_id not found Others Others Others Others Others 1q23                                          
1q3a MMP10_HUMAN P09238 K01396 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Stromelysin 2 1q3a                                          
1q3d GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 1q3d                                          
1q41 GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 1q41                                          
1qca CAT3_ECOLX P00484 K03781 Enzymes Oxidoreductases Acting on a peroxide as acceptor Peroxidases Catalase 1qca                                          
        Enzymes         1qcf   1qcf-pp1-2.00-h-1-s 1349 oncolytic hck EC2.- (transferases) kinases (tyrosine) Hck cancer no info pp1 2.00 0 Cc1ccc(cc1)[C@H]2NN(c3ncnc(N)c23)C(C)(C)C 0 CAS Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J Mol Cell 3(5):639-48 1999 10.1016/S1097-2765(00)80357-3
1qpe LCK_HUMAN P06239 K05856 CAM ligands Immunoglobulin Superfamily Immune system CD2 family CD48, BCM1; CD48 antigen [KO- ] 1qpe                                          
1qy8 ENPL_CANFA P41148 K09487 Chaperones and folding catalysts Heat shock proteins HSP90 K09487 HSP90B, TRA1; heat shock protein 90kDa beta Endoplasmic reticulum 1qy8                                          
1qyx DHB1_HUMAN P14061 K00044 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Estradiol 17beta-dehydrogenase 1qyx                                          
1r20 Q7SIF6_HELVI Q7SIF6 KO_id not found Others Others Others Others Others 1r20                                          
        Enzymes         1r9o   1r9o-flp-2.00-x-2-s 2042 metabolism cytochrome P450 2C9 EC1.- (oxydo-reductases) monooxygenases CYP 2C9 ADMET ligand is a substrate of P450 2C9; drug-drug interactions possible flp 2.00 flurbiprofen CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 5104-49-4 cas The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution Wester MR, Yano JK, Schoch GA, Yang C, Griffin KJ, Stout CD, Johnson EF J Biol Chem 279(34):35630-7 2004 10.1074/jbc.M405427200
        Enzymes         1r9o   1r9o-flp-2.00-x-2 22264 metabolism cytochrome P450 2C9 EC1.- (oxydo-reductases) monooxygenases CYP 2C9 ADMET ligand is a substrate of P450 2C9; drug-drug interactions possible flp 2.00 flurbiprofen CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 5104-49-4 cas The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution Wester MR, Yano JK, Schoch GA, Yang C, Griffin KJ, Stout CD, Johnson EF J Biol Chem 279(34):35630-7 2004 10.1074/jbc.M405427200
        Transport proteins         1rbp   1rbp-rtl-2.00-d-1-s 1124 other class
technologic
retinol binding protein extracellular proteins serum proteins RBP ADMET
fundamental research
binding and transport of small ligand compounds with appropriate features rtl 2.00 retinol C/C(=C\CO)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 68-26-8 cas Crystallographic refinement of human serum retinol binding protein at 2A resolution Cowan SW, Newcomer ME, Jones TA Proteins 8(1):44-61 1990 -
1rev POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1rev                                          
        Enzymes         1rkp   1rkp-ibm-2.05-x-1-s 3.818046234 cardiovascular phosphodiesterase 5A EC3.- (hydrolases) phosphodiesterases PDE 5A cardiovascular diseases inhibition of cGMP degradation ibm 2.05 3-isobutyl-1-methylxanthine CC(C)CN1C2=C(C(=O)N(C1=O)C)N=CN2 28822-58-4 CAS Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity Huai Q, Liu Y, Francis SH, Corbin JD, Ke H J Biol Chem 279(13):13095-101 2004 10.1074/jbc.M311556200
1rq9 Q5RTL1_9HIV1 Q5RTL1 KO_id not found Others Others Others Others Others 1rq9                                          
        Enzymes         1rt1   1rt1-mkc-2.55-d-1-s 1042 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
mkc 2.55 emivirine CCOCn1c(Cc2ccccc2)c(C(C)C)c(=O)[nH]c1=O 149950-60-7 cas Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C, Miyasaka T, Walker RT, Tanaka H, Stammers DK, Stuart DI J Med Chem 39(8):1589-600 1996 10.1021/jm960056x
1rt1 POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1rt1                                          
1rt5 POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1rt5                                          
1rt6 POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1rt6                                          
1rt7 POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1rt7                                          
        Enzymes         1rth   1rth-u05-2.20-d-1-s 1871 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
u05 2.20 1051U91 CCN1c2ncccc2C(=O)N(C)c3ccc(nc13)N(=O)=O 163046-77-3 cas High resolution structures of HIV-1 RT from four RT-inhibitor complexes Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D, et al. Nat Struct Biol 2(4):293-302 1995 10.1038/nsb0495-293
1rw8 TGFR1_HUMAN P36897 K04674 Cytokine receptors TGF-beta receptors Type I TGF-beta receptor TGFBR1; TGF-beta receptor type-1 Others 1rw8                                          
1ry0 AK1C3_HUMAN P42330 K00089 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 3alpha-hydroxysteroid dehydrogenase (A-specific) 1ry0                                          
1s1t POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1s1t                                          
        Enzymes         1s2c   1s2c-flf-1.80-x-2-s 2059 endocrine 17beta-hydroxysteroid dehydrogenase type 5 EC1.- (oxydo-reductases) steroid dehydrogenases 17beta-HSD 5 contraception (male)
cancer
17beta-HSD 5 is a labile enzyme that catalyzes the transformation of 4-androstene-3, 17-dione into testosterone (like 17beta-HSD 3) and also exerts high 20alpha-dihydroprogesterone activity thereby inactivating progesterone. flf 1.80 flufenamic acid OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 530-78-9 cas Crystal structure of human prostaglandin F synthase (AKR1C3) Komoto J, Yamada T, Watanabe K, Takusagawa F Biochemistry 43(8):2188-98 2004 10.1021/bi036046x
1s2c AK1C3_HUMAN P42330 K00089 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 3alpha-hydroxysteroid dehydrogenase (A-specific) 1s2c                                          
1s64 FNTA_RAT Q04631 K05955 Enzymes Transferases Transferring alkyl or aryl groups, other than methyl groups Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) Protein farnesyltransferase 1s64                                          
1s9d ARF1_BOVIN P84080 K07937 GTP-binding proteins Small (Monomeric) G-proteins Arf-Sar Family Arf-Arl1 ARF1; ADP-ribosylation factor 1 1s9d                                          
1sbr YKOF_BACSU O34911 KO_id not found Others Others Others Others Others 1sbr                                          
1sd2 MTAP_HUMAN Q13126 K00772 Enzymes Transferases Glycosyltransferases Pentosyltransferases S-methyl-5'-thioadenosine phosphorylase 1sd2                                          
1sjw Q9RN59_STRNO Q9RN59 KO_id not found Others Others Others Others Others 1sjw                                          
        Enzymes         1so2   1so2-666-2.40-p-2-s 1.04847129008203 metabolic phosphodiesterase 3B
cGMP-inhibited PDE
EC3.- (hydrolases) phosphodiesterases PDE 3B obesity development of leptin resistence, inhibition of glycogenolysis, regulator of glucose-mediated insulin release 666 2.40 Merck1 C[C@@H]1CC(=O)NN=C1C2=CC=C(C=C2)NC3=C(C(=O)CCC3)CC=4C=CC=C(C4)I 544985-13-7 CAS Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity Scapin G, Patel SB, Chung C, Varnerin JP, Edmondson SD, Mastracchio A, Parmee ER, Singh SB, Becker JW, Van der Ploeg LH, Tota MR Biochemistry 43(20):6091-100 2004 10.1021/bi049868i
1so2 PDE3B_HUMAN Q13370 K13296 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1so2                                          
1sqn PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 1sqn                                          
1srg SAV_STRAV P22629 KO_id not found Other proteins Bacterial proteins binding proteins streptavidin Others 1srg 1895                                        
        Other proteins         1sri   1sri-dmb-1.65-d-1-s 899 antiinfective streptavidin Bacterial proteins binding proteins streptavidin fundamental research stabilisation of streptavidin
tool for universal test systems in immunology and molecular diagnostics
system for analysis of intermolecular interactions of the tight binding of the small molecule ligand biotin to the protein
dmb 1.65 78733-42-3 Cc1cc(cc(C)c1O)N=Nc2ccccc2C(O)=O 78733-42-3 CAS Structure-Based Design of Synthetic Azobenzene Ligands for Streptavidin Weber PC, Pantoliano MW, Simons DM, Salemme FR J.Am.Chem.Soc v116 pp.2717 1994 10.1021/ja00086a004
        Enzymes         1sv5   1sv5-65b-2.90-d-1 1177 antiinfective HIV-1 reverse transcriptase EC2.- (transferases) reverse transcriptases RT (HIV-1) HIV infection inhibition of reverse transcription of viral RNA to DNA
prevention of integration of viral genetic information into host cell genome
65b 2.90 etravirine Cc1cc(C#N)cc(C)c1Oc2nc(Nc3ccc(C#N)cc3)nc(N)c2Br 269055-15-4 cas Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, Andries K, Pauwels R, De Bethune MP, Boyer PL, Clark P, Hughes SH, Janssen PA, Arnold E J Med Chem 47(10):2550-60 2004 10.1021/jm030558s
1szm KAPCA_BOVIN P00517 K04345 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases CAMP-dependent protein kinase 1szm                                          
1t2w Q9S446_STAAU Q9S446 KO_id not found Others Others Others Others Others 1t2w                                          
1t47 HPPD_STRAW Q53586 K00457 Enzymes Oxidoreductases Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2 With incorporation of two atoms of oxygen 4-hydroxyphenylpyruvate dioxygenase 1t47                                          
1t4j PTN1_HUMAN P18031 K05696 Enzymes Hydrolases Acting on ester bonds Phosphoric-monoester hydrolases Protein-tyrosine-phosphatase 1t4j                                          
1t64 HDAC8_HUMAN Q9BY41 K11405 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides Histone deacetylase 1t64                                          
1ta2 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 1ta2                                          
1tbb PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1tbb                                          
1tbf PDE5A_HUMAN O76074 K13762 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 1tbf                                          
1tkt POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1tkt                                          
1tkx POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1tkx                                          
1tkz POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1tkz                                          
1tl1 POL_HV1H2 P04585 KO_id not found Enzymes 2. Transferases reverse transcriptases RT (HIV-1) Others 1tl1                                          
1tou FABP4_HUMAN P15090 KO_id not found Others Others Others Others Others 1tou                                          
1tz8 TTHY_HUMAN P02766 KO_id not found Others Others Others Others Others 1tz8                                          
1u3r ESR2_HUMAN Q92731 K08551 Nuclear receptors Estrogen like A. Estrogen receptor NR3A2, ESR2; estrogen receptor beta Others 1u3r                                          
1u59 ZAP70_HUMAN P43403 K07360 Cellular antigens Non-CD molecules ZAP70; zeta-chain (TCR) associated protein kinase 70kDa Others Others 1u59                                          
        Enzymes         1udu   1udu-cia-2.80-x-1-s 1.285607755 cardiovascular phosphodiesterase 5A EC3.- (hydrolases) phosphodiesterases PDE 5A cardiovascular diseases inhibition of cGMP degradation cia 2.80 tadalafil CN1CC(=O)N2[C@@H](C1=O)CC=3C4=CC=CC=C4NC3[C@H]2C5=CC=C6C(=C5)OCO6 171596-29-5 CAS Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Sung BJ, Hwang KY, Jeon YH, Lee JI, Heo YS, Kim JH, Moon J, Yoon JM, Hyun YL, Kim E, Eum SJ, Park SY, Lee JO, Lee TG, Ro S, Cho JM Nature 425(6953):98-102 2003 10.1038/nature01914
        Enzymes         1uh5   1uh5-tcl-2.20-d-1 2.20432513 antiinfective parasitic enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) malaria
parasitic infection
inhibition of final step in parasitic fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in parasites
tcl 2.20 triclosan Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl 3380-34-5 cas Structural Basis for the Variation in Triclosan Affinity to Enoyl Reductases Swarnamukhi PL, Kapoor M, Surolia N, Surolia A, Suguna K J Mol Biol 343, 147-155 2004 10.1016/j.jmb.2004.08.033
1uho PDE5A_HUMAN O76074 K13762 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 1uho                                          
1unh CDK5_HUMAN Q00535 K02090 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 1unh                                          
1uu3 PDPK1_HUMAN O15530 K06276 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 1uu3                                          
1uu7 PDPK1_HUMAN O15530 K06276 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 1uu7                                          
1uv5 GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 1uv5                                          
1uyr ACAC_YEAST Q00955 K11262 Enzymes Ligases Forming carbon-nitrogen bonds Other carbon-nitrogen ligases Biotin carboxylase 1uyr                                          
1uys ACAC_YEAST Q00955 K11262 Enzymes Ligases Forming carbon-nitrogen bonds Other carbon-nitrogen ligases Biotin carboxylase 1uys                                          
1v3x FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 1v3x                                          
1v79 ADA_BOVIN P56658 K01488 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In cyclic amidines Adenosine deaminase 1v79                                          
1vjy TGFR1_HUMAN P36897 K04674 Cytokine receptors TGF-beta receptors Type I TGF-beta receptor TGFBR1; TGF-beta receptor type-1 Others 1vjy                                          
        Structuring proteins         1vrh   1vrh-sd8-3.00-d-1 1995 antiinfective HRV coat protein Cellular level viral coat proteins VP1-4 (HRV) common cold inhibition of viral entry into host cell and/or uncoating
occupation of a hydrophobic pocket and consequent stabilisation of viral capsid
sd8 3.00 SDZ 880-061 CCOC(=O)c1csc(n1)N2CCN(CC2)C3=Nc4ccccc4SC3 178433-80-2 CAS Synthesis and activity of piperazine-containing antirhinoviral agents and crystal structure of SDZ 880-061 bound to human rhinovirus 14 Oren DA, Zhang A, Nesvadba H, Rosenwirth B, Arnold E J Mol Biol 259(1):120-34 1996 10.1006/jmbi.1996.0307
        Enzymes         1w0g   1w0g-myt-2.74-x-1-s 2311 ADMET cytochrome P450 3A4 EC1.- (oxydo-reductases) monooxygenases CYP 3A4 ADMET P450 3A4 inhibitors can cause severe drug-drug interactions myt 2.74 metyrapone CC(C)(C(=O)c1cccnc1)c2cccnc2 54-36-4 cas Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H Science 305(5684):683-6 2004 10.1126/science.1099736
        Enzymes         1w0g   1w0g-myt-2.74-x-1 13889 ADMET cytochrome P450 3A4 EC1.- (oxydo-reductases) monooxygenases CYP 3A4 ADMET P450 3A4 inhibitors can cause severe drug-drug interactions myt 2.74 metyrapone CC(C)(C(=O)c1cccnc1)c2cccnc2 54-36-4 cas Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H Science 305(5684):683-6 2004 10.1126/science.1099736
1w0x CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 1w0x                                          
1wbv MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 1wbv                                          
1wbw MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 1wbw                                          
1wok PARP1_HUMAN P09874 K10798 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 1wok                                          
1wxy ADA_BOVIN P56658 K01488 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In cyclic amidines Adenosine deaminase 1wxy                                          
1wzy MK01_HUMAN P28482 K04371 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 1wzy                                          
1xbc KSYK_HUMAN P43405 K05855 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 1xbc                                          
1xdk RXRA_MOUSE P28700 K08524 Nuclear receptors Hepatocyte nuclear factor 4 like B. Retinoid X receptor (RXR) NR2B1, RXRA; retinoid X receptor alpha Others 1xdk                                          
        Enzymes         1xiv   1xiv-rb2-1.70-d-1-s 0.94556301 antiinfective plasmodium falciparum lactate dehydrogenase EC1.- (oxydo-reductases) lactate dehydrogenases LDH (P.falciparum) parasitic infection inhibition of parasitic lactate dehydrogenase (glycolysis as energy source) rb2 1.70 877066-60-9 COC(=O)c1cc(Cl)ccc1NC(=O)C(=O)O 877066-60-9 cas Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase Conners R, Schambach F, Read J, Cameron A, Sessions RB, Vivas L, Easton A, Croft SL, Brady RL Mol Biochem Parasitol 142(2):137-48 2005 10.1016/j.molbiopara.2005.03.015
1xls RXRA_HUMAN P19793 K08524 Nuclear receptors Hepatocyte nuclear factor 4 like B. Retinoid X receptor (RXR) NR2B1, RXRA; retinoid X receptor alpha Others 1xls                                          
1xlx PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1xlx                                          
1xlz PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1xlz                                          
1xm4 PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1xm4                                          
1xm6 PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1xm6                                          
1xmu PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1xmu                                          
1xnn ANDR_RAT P15207 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 1xnn                                          
1xom PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1xom                                          
1xoq PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1xoq                                          
1xow ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 1xow                                          
1xp0 PDE5A_HUMAN O76074 K13762 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 1xp0                                          
1y2e PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1y2e                                          
1y2g ZIPA_ECOLI P77173 KO_id not found Others Others Others Others Others 1y2g                                          
1y2h PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1y2h                                          
1y2k PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 1y2k                                          
1y6a VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 1y6a                                          
1y8j NEP_HUMAN P08473 K01389 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Neprilysin 1y8j                                          
1ygj PDXK_SHEEP P82197 K00868 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Pyridoxal kinase 1ygj                                          
1ygk PDXK_SHEEP P82197 K00868 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Pyridoxal kinase 1ygk                                          
1yhj PDXK_SHEEP P82197 K00868 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Pyridoxal kinase 1yhj                                          
1yrs KIF11_HUMAN P52732 K10398 Cytoskeleton proteins Eukaryotic cytoskeleton proteins Microtubules Tubulin-binding proteins KIF11; kinesin family member 11 1yrs                                          
        Enzymes         1yvf   1yvf-ph7-2.50-d-1 2839 antiinfective RNA-dependent RNA polymerase (NS5B) from hepatitic C virus EC2.- (transferases) RNA polymerases NS5B (HCV) hepatitis C virus infection inhibition of viral replication
inhibition of transcription of viral genomic RNA and consequently of viral genome replication
ph7 2.50 PHA 729145 OC(=O)\C(NC(=O)c1ccccc1)=C\c2ccc(Oc3ccccc3Br)cc2 639517-90-1 CAS Inhibitors of HCV NS5B polymerase: Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris MS, Wells PA., Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ Bioorg.Med.Chem.Lett. v15 pp.2481-2486 2005 10.1016/j.bmcl.2005.03.066
1yw7 AMPM2_HUMAN P50579 K01265 Enzymes Hydrolases Acting on peptide bonds (peptidases) Aminopeptidases Methionyl aminopeptidase 1yw7                                          
1yw8 AMPM2_HUMAN P50579 K01265 Enzymes Hydrolases Acting on peptide bonds (peptidases) Aminopeptidases Methionyl aminopeptidase 1yw8                                          
1yw9 AMPM2_HUMAN P50579 K01265 Enzymes Hydrolases Acting on peptide bonds (peptidases) Aminopeptidases Methionyl aminopeptidase 1yw9                                          
        Enzymes         1yxx   1yxx-li7-2.00-h-1-s 1676 no info pim1
proto oncogene kinase
EC2.- (transferases) kinases (serine-threonine) Pim-1 cancer no info li7 2.00 0 Oc1[nH]c2ccccc2c1Nc3ccc(O)cc3 0 CAS Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma Kumar A, Mandiyan V, Suzuki Y, Zhang C, Rice J, Tsai J, Artis DR, Ibrahim P, Bremer R J Mol Biol 348(1):183-93 2005 10.1016/j.jmb.2005.02.039
1z89 ALDR_HUMAN P15121 K00011 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Aldehyde reductase 1z89                                          
1zdp THER_BACTH P00800 KO_id not found Others Others Others Others Others 1zdp                                          
1ze8 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 1ze8                                          
1zeo PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 1zeo                                          
1zgi THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 1zgi                                          
1zht KES1_YEAST P35844 KO_id not found Others Others Others Others Others 1zht                                          
1zhx KES1_YEAST P35844 KO_id not found Others Others Others Others Others 1zhx                                          
1zhz KES1_YEAST P35844 KO_id not found Others Others Others Others Others 1zhz                                          
1zkk SETD8_HUMAN Q9NQR1 K11428 Enzymes Transferases Transferring one-carbon groups Methyltransferases Histone-lysine N-methyltransferase 1zkk                                          
        Enzymes         1zsn   1zsn-tn2-2.99-d-1-s 0.12378822 antiinfective parasitic enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) malaria
parasitic infection
inhibition of final step in parasitic fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in parasites
tn2 2.99 36859-73-1 O=N(=O)c2ccc(Oc1ccc(Cl)cc1O)c(Cl)c2 36859-73-1 cas Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR Jr, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC Bioorg Med Chem Lett 15(23):5247-52 2005 10.1016/j.bmcl.2005.08.044
        Enzymes         1zsn   1zsn-tn2-2.99-d-1 1.02609993 antiinfective parasitic enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) malaria
parasitic infection
inhibition of final step in parasitic fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in parasites
tn2 2.99 36859-73-1 O=N(=O)c2ccc(Oc1ccc(Cl)cc1O)c(Cl)c2 36859-73-1 cas Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR Jr, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC Bioorg Med Chem Lett 15(23):5247-52 2005 10.1016/j.bmcl.2005.08.044
        Enzymes         1zw1   1zw1-tn5-2.90-d-1-s 0.06263982 antiinfective parasitic enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) malaria
parasitic infection
inhibition of final step in parasitic fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in parasites
tn5 2.90 871103-52-5 Nc2ccc(Oc1ccc(Cl)cc1O)c(Cl)c2 871103-52-5 cas Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR Jr, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC Bioorg Med Chem Lett 15(23):5247-52 2005 10.1016/j.bmcl.2005.08.044
        Enzymes         1zw1   1zw1-tn5-2.90-d-1 0.22371365 antiinfective parasitic enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (P.falciparum) malaria
parasitic infection
inhibition of final step in parasitic fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in parasites
tn5 2.90 871103-52-5 Nc2ccc(Oc1ccc(Cl)cc1O)c(Cl)c2 871103-52-5 cas Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR Jr, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC Bioorg Med Chem Lett 15(23):5247-52 2005 10.1016/j.bmcl.2005.08.044
1zyj MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 1zyj                                          
1zzl MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 1zzl                                          
2aa6 MCR_HUMAN P08235 K08555 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C2, MR; mineralocorticoid receptor Others 2aa6                                          
2ab2 MCR_HUMAN P08235 K08555 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C2, MR; mineralocorticoid receptor Others 2ab2                                          
2ax6 ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 2ax6                                          
2ax8 ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 2ax8                                          
2ax9 ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 2ax9                                          
        Enzymes         2b36   2b36-5pp-2.80-d-1-s 0.15063386 antiinfective bacterial enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (M.tuberculosis) tuberculosis
bacterial infection
inhibition of final step in bacterial fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in bacteria
5pp 2.80 877206-68-3 CCCCCc2ccc(Oc1ccccc1)c(O)c2 877206-68-3 cas High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis Sullivan TJ, Truglio JJ, Boyne ME, Novichenok P, Zhang X, Stratton C, Li HJ, Kaur T, Amin A, Johnson F, Slayden RA, Kisker C, Tonge PJ ACS Chem Biol, 1, 43-53 2006 10.1021/cb0500042
        Enzymes         2b36   2b36-5pp-2.80-d-1 0.64578673 antiinfective bacterial enoyl acyl carrier protein reductase EC1.- (oxydo-reductases) CH-CH NAD(P)+ oxidoreductases enoyl-ACP reductase (M.tuberculosis) tuberculosis
bacterial infection
inhibition of final step in bacterial fatty acid elongation in fatty acid synthesis type II pathway, FAS-II
deprivation of critical metabolic precursors of biological membranes and important form of metabolic energy in bacteria
5pp 2.80 877206-68-3 CCCCCc2ccc(Oc1ccccc1)c(O)c2 877206-68-3 cas High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis Sullivan TJ, Truglio JJ, Boyne ME, Novichenok P, Zhang X, Stratton C, Li HJ, Kaur T, Amin A, Johnson F, Slayden RA, Kisker C, Tonge PJ ACS Chem Biol, 1, 43-53 2006 10.1021/cb0500042
2b37 INHA_MYCTU P0A5Y6 K05500 Lipid biosynthesis proteins TGF-beta family Distant members INHA; inhibin, alpha Others 2b37                                          
2bgd PTN1_HUMAN P18031 K05696 Enzymes Hydrolases Acting on ester bonds Phosphoric-monoester hydrolases Protein-tyrosine-phosphatase 2bgd                                          
2bhe CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2bhe                                          
2bik PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2bik                                          
2bmc AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2bmc                                          
2boh FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2boh                                          
2br1 CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2br1                                          
2brb CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2brb                                          
        Enzymes         2brh   2brh-dfw-2.10-h-1-s 1730 no info serin-threonin kinase EC2.- (transferases) kinases (serine-threonine) Chk1 cancer no info dfw 2.10 701223-63-4 OC(=O)CNc1ncnc2oc(c(c3ccccc3)c12)c4ccccc4 701223-63-4 CAS Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity Foloppe N, Fisher LM, Howes R, Kierstan P, Potter A, Robertson AG, Surgenor AE J Med Chem 48(13):4332-45 2005 10.1021/jm049022c
2brm CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2brm                                          
2bro CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2bro                                          
2bsx Q8T9Z7_PLAFA Q8T9Z7 KO_id not found Others Others Others Others Others 2bsx                                          
2btr CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2btr                                          
2bu7 PDK2_HUMAN Q15119 K00898 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases [pyruvate dehydrogenase (acetyl-transferring)] kinase 2bu7                                          
2buj STK16_HUMAN O75716 K08856 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2buj                                          
2bxf ALBU_HUMAN P02768 KO_id not found Others Others Others Others Others 2bxf                                          
2c5n CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2c5n                                          
2c5x CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2c5x                                          
2chw PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 2chw                                          
2chz PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 2chz                                          
2dq7 FYN_HUMAN P06241 K05703 CAM ligands 1. Immunoglobulin Superfamily Immune system CD2 family Tyrosine-protein kinase Fyn 2dq7 9606                                        
2ds1 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2ds1                                          
2e9u CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2e9u                                          
2e9v CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2e9v                                          
2ea2 AMPM2_HUMAN P50579 K01265 Enzymes Hydrolases Acting on peptide bonds (peptidases) Aminopeptidases Methionyl aminopeptidase 2ea2                                          
2ei6 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2ei6                                          
2f1o NQO1_HUMAN P15559 K00355 Enzymes Oxidoreductases Acting on NADH or NADPH With a quinone or similar compound as acceptor NAD(P)H dehydrogenase (quinone) 2f1o                                          
2g97 NAMPT_RAT Q80Z29 K03462 Enzymes Transferases Glycosyltransferases Pentosyltransferases Nicotinamide phosphoribosyltransferase 2g97                                          
        Receptors         2gtk   2gtk-208-2.10-p-1-s 2.71140939597315 metabolic peroxisome proliferator-activated receptor gamma Transduction factor receptors nuclear hormone receptors PPAR-gamma obesity activation of peroxisome proliferator-activated receptor gamma
central regulator of adipocyte differentiation, fatty acid metabolism and glucose homeostasis; inhibition of inflammatory cytokines and other proteins
208 2.10 671215-78-4 CCO[C@@H](CC1=CC=C2C(=C1)C=CN2CC3=C(OC(=N3)C4=CC=CC=C4Cl)C)C(=O)O 671215-78-4 CAS Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Marki HP, Meyer M, Mohr P Bioorg Med Chem Lett 16(15):4016-20 2006 10.1016/j.bmcl.2006.05.007
2gvj NAMPT_HUMAN P43490 K03462 Enzymes Transferases Glycosyltransferases Pentosyltransferases Nicotinamide phosphoribosyltransferase 2gvj                                          
2h2i NPD_THEMA Q9WYW0 K12410 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides - 2h2i                                          
2hka NPC2_BOVIN P79345 K13443 Others Cellular Processes Transport and catabolism Lysosome NPC2; Niemann-Pick C2 protein 2hka                                          
2hkj TOP6B_SULSH O05207 KO_id not found Others Others Others Others Others 2hkj                                          
2hpy OPSD_BOVIN P02699 K04250 G protein-coupled receptors Class A. Rhodopsin family Vision Opsin RHO, OPN2; rhodopsin 2hpy                                          
2hvc ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 2hvc                                          
2hxq CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2hxq                                          
2hy0 CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2hy0                                          
2i1m CSF1R_HUMAN P07333 K05090 Cellular antigens CD (clusters of differentiation) molecules CD115; colony stimulating factor 1 receptor (macrophage) Others Others 2i1m                                          
2i80 DDL_STAAC Q5HEB7 K01921 Enzymes Ligases Forming carbon-nitrogen bonds Acid-D-amino-acid ligases (peptide synthases) D-alanine---D-alanine ligase 2i80                                          
2ic3 POL_HV1B1 P03366 KO_id not found Others Others Others Others Others 2ic3                                          
2ilt DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 2ilt                                          
2ipf AK1CL_MOUSE Q91WR5 KO_id not found Others Others Others Others Others 2ipf                                          
        Enzymes         2irw   2irw-nn4-3.10-x-1-s 0.721849366144 endocrine, metabolic 11beta-hydroxysteroid dehydrogenase type 1 EC1.- (oxydo-reductases) steroid dehydrogenases 11beta-HSD 1 non-insulin dependent diabetes mellitus
obesity
neurodegenerative diseases
cognitive defects (age- and dementia-associated)
metabolic disorders
inhibition of the conversion of inactive cortison into acitve cortisol nn4 3.10 898264-92-1 CC(C)(C(=O)NC1[C@H]2CC3C[C@@H]1CC(C3)(C2)C(=O)N)OC=4C=CC(=CC4)OC 898264-92-1 cas Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation Patel JR, Shuai Q, Dinges J, Winn M, Pliushchev M, Fung S, Monzon K, Chiou W, Wang J, Pan L, Wagaw S, Engstrom K, Kerdesky FA, Longenecker K, Judge R, Qin W, Imade HM, Stolarik D, Beno DW, Brune M, Chovan LE, Sham HL, Jacobson P, Link JT Bioorg Med Chem Lett 17(3):750-5 2007 10.1016/j.bmcl.2006.10.074
        Enzymes         2irw   2irw-nn4-3.10-x-1 2.751677852 endocrine, metabolic 11beta-hydroxysteroid dehydrogenase type 1 EC1.- (oxydo-reductases) steroid dehydrogenases 11beta-HSD 1 non-insulin dependent diabetes mellitus
obesity
neurodegenerative diseases
cognitive defects (age- and dementia-associated)
metabolic disorders
inhibition of the conversion of inactive cortison into acitve cortisol nn4 3.10 898264-92-1 CC(C)(C(=O)NC1[C@H]2CC3C[C@@H]1CC(C3)(C2)C(=O)N)OC=4C=CC(=CC4)OC 898264-92-1 cas Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation Patel JR, Shuai Q, Dinges J, Winn M, Pliushchev M, Fung S, Monzon K, Chiou W, Wang J, Pan L, Wagaw S, Engstrom K, Kerdesky FA, Longenecker K, Judge R, Qin W, Imade HM, Stolarik D, Beno DW, Brune M, Chovan LE, Sham HL, Jacobson P, Link JT Bioorg Med Chem Lett 17(3):750-5 2007 10.1016/j.bmcl.2006.10.074
        Enzymes         2irw   2irw-nn4-3.10-x-2-s 3.33386201427 endocrine, metabolic 11beta-hydroxysteroid dehydrogenase type 1 EC1.- (oxydo-reductases) steroid dehydrogenases 11beta-HSD 1 non-insulin dependent diabetes mellitus
obesity
neurodegenerative diseases
cognitive defects (age- and dementia-associated)
metabolic disorders
inhibition of the conversion of inactive cortison into acitve cortisol nn4 3.10 898264-92-1 CC(C)(C(=O)NC1[C@H]2CC3C[C@@H]1CC(C3)(C2)C(=O)N)OC=4C=CC(=CC4)OC 898264-92-1 cas Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation Patel JR, Shuai Q, Dinges J, Winn M, Pliushchev M, Fung S, Monzon K, Chiou W, Wang J, Pan L, Wagaw S, Engstrom K, Kerdesky FA, Longenecker K, Judge R, Qin W, Imade HM, Stolarik D, Beno DW, Brune M, Chovan LE, Sham HL, Jacobson P, Link JT Bioorg Med Chem Lett 17(3):750-5 2007 10.1016/j.bmcl.2006.10.074
        Enzymes         2irw   2irw-nn4-3.10-x-2 3.1841909023117 endocrine, metabolic 11beta-hydroxysteroid dehydrogenase type 1 EC1.- (oxydo-reductases) steroid dehydrogenases 11beta-HSD 1 non-insulin dependent diabetes mellitus
obesity
neurodegenerative diseases
cognitive defects (age- and dementia-associated)
metabolic disorders
inhibition of the conversion of inactive cortison into acitve cortisol nn4 3.10 898264-92-1 CC(C)(C(=O)NC1[C@H]2CC3C[C@@H]1CC(C3)(C2)C(=O)N)OC=4C=CC(=CC4)OC 898264-92-1 cas Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation Patel JR, Shuai Q, Dinges J, Winn M, Pliushchev M, Fung S, Monzon K, Chiou W, Wang J, Pan L, Wagaw S, Engstrom K, Kerdesky FA, Longenecker K, Judge R, Qin W, Imade HM, Stolarik D, Beno DW, Brune M, Chovan LE, Sham HL, Jacobson P, Link JT Bioorg Med Chem Lett 17(3):750-5 2007 10.1016/j.bmcl.2006.10.074
2ivd PPOX_MYXXA P56601 K00231 Enzymes Oxidoreductases Acting on the CH-CH group of donors With oxygen as acceptor Protoporphyrinogen oxidase 2ivd                                          
2j2u FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2j2u                                          
2j4i FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2j4i                                          
2j50 AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2j50                                          
2j94 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2j94                                          
2jh0 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2jh0                                          
2jh5 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2jh5                                          
2jh6 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2jh6                                          
2jko FAK1_CHICK Q00944 K05725 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 2jko                                          
2nsd INHA_MYCTU P0A5Y6 K05500 Lipid biosynthesis proteins TGF-beta family Distant members INHA; inhibin, alpha Others 2nsd                                          
2nw4 ANDR_RAT P15207 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 2nw4                                          
2o7n ITAL_HUMAN P20701 K05718 Cellular antigens CD (clusters of differentiation) molecules CD11a; integrin alpha L Others Others 2o7n                                          
2o8h PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 2o8h                                          
2ofv LCK_HUMAN P06239 K05856 CAM ligands Immunoglobulin Superfamily Immune system CD2 family CD48, BCM1; CD48 antigen [KO- ] 2ofv                                          
2oi0 ADA17_HUMAN P78536 K06059 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases ADAM 17 endopeptidase 2oi0                                          
2oj9 IGF1R_HUMAN P08069 K05087 Cellular antigens CD (clusters of differentiation) molecules CD221; insulin-like growth factor 1 receptor Others Others 2oj9                                          
2on6 PNPH_HUMAN P00491 K03783 Enzymes Transferases Glycosyltransferases Pentosyltransferases Purine-nucleoside phosphorylase 2on6                                          
2op0 Q9BH77_PLAFA Q9BH77 KO_id not found Others Others Others Others Others 2op0                                          
2ops POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 2ops                                          
2ovh PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 2ovh                                          
2ovv PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 2ovv                                          
2ovy PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 2ovy                                          
2oxd CSK2A_MAIZE P28523 KO_id not found Others Others Others Others Others 2oxd                                          
2p0m LOX15_RABIT P12530 K00460 Enzymes Oxidoreductases Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2 With incorporation of two atoms of oxygen Arachidonate 15-lipoxygenase 2p0m                                          
2p2h VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 2p2h                                          
2p2i VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 2p2i                                          
2p4y PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 2p4y                                          
2p95 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2p95                                          
2pdg ALDR_HUMAN P15121 K00011 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Aldehyde reductase 2pdg                                          
2phb FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2phb                                          
2pvh CSK2A_MAIZE P28523 KO_id not found Others Others Others Others Others 2pvh                                          
2pvj CSK2A_MAIZE P28523 KO_id not found Others Others Others Others Others 2pvj                                          
2pw3 PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 2pw3                                          
2pzi PKNG_MYCTU P65728 K14949 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2pzi                                          
2q7i ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 2q7i                                          
2q7k ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 2q7k                                          
2q7o PNPH_HUMAN P00491 K03783 Enzymes Transferases Glycosyltransferases Pentosyltransferases Purine-nucleoside phosphorylase 2q7o                                          
2q8g PDK1_HUMAN Q15118 K12077 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases [pyruvate dehydrogenase (acetyl-transferring)] kinase 2q8g                                          
2q8i PDK3_HUMAN Q15120 K00898 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases [pyruvate dehydrogenase (acetyl-transferring)] kinase 2q8i                                          
2q95 AMPM_ECOLI P0AE18 K01265 Enzymes Hydrolases Acting on peptide bonds (peptidases) Aminopeptidases Methionyl aminopeptidase 2q95                                          
2qc6 CSK2A_MAIZE P28523 KO_id not found Others Others Others Others Others 2qc6                                          
2qio Q81JF8_BACAN Q81JF8 K00208 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor Enoyl-[acyl-carrier-protein] reductase (NADH) 2qio                                          
2qo8 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 2qo8                                          
2qr9 ESR1_HUMAN P03372 K08550 Nuclear receptors Estrogen like A. Estrogen receptor NR3A1, ESR1; estrogen receptor alpha Others 2qr9                                          
2r3f CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2r3f                                          
2r3j CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2r3j                                          
2r3k CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2r3k                                          
2r3p CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2r3p                                          
2r4b ERBB4_HUMAN Q15303 K05085 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Receptor protein-tyrosine kinase 2r4b                                          
2r7b PDPK1_HUMAN O15530 K06276 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2r7b                                          
2rbe DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 2rbe                                          
2rct RET2_HUMAN P50120 KO_id not found Others Others Others Others Others 2rct                                          
2rcw PARP1_HUMAN P09874 K10798 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 2rcw                                          
2rfs MET_HUMAN P08581 K05099 Cellular antigens Non-CD molecules MET; met proto-oncogene (hepatocyte growth factor receptor) Others Others 2rfs                                          
2rgp EGFR_HUMAN P00533 K04361 Cytokine receptors Receptor tyrosine kinase RTK class I (EGF receptor family) EGFR, ERBB1; epidermal growth factor receptor Others 2rgp                                          
2rki POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 2rki                                          
2rkv Q9HDE2_GIBZA Q9HDE2 KO_id not found Others Others Others Others Others 2rkv                                          
2tsr TYSY_RAT P45352 K00560 Enzymes Transferases Transferring one-carbon groups Methyltransferases Thymidylate synthase 2tsr                                          
2uwo FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2uwo                                          
2uwu RCEL_RHOSH P0C0Y8 KO_id not found Others Others Others Others Others 2uwu                                          
2uym KIF11_HUMAN P52732 K10398 Cytoskeleton proteins Eukaryotic cytoskeleton proteins Microtubules Tubulin-binding proteins KIF11; kinesin family member 11 2uym                                          
        Enzymes         2v0m   2v0m-kln-3.80-x-1-s 24.19090 ADMET cytochrome P450 3A4 EC1.- (oxydo-reductases) monooxygenases CYP 3A4 ADMET P450 3A4 inhibitors can cause severe drug-drug interactions kln 3.80 ketoconazole [CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2] 65277-42-1 CAS Structural basis for ligand promiscuity in cytochrome P450 3A4 Ekroos M, Sjogren T Proc Natl Acad Sci U S A 103(37):13682-7 2006 10.1073/pnas.0603236103
        Enzymes         2v0m   2v0m-kln-3.80-x-1 28.24012 ADMET cytochrome P450 3A4 EC1.- (oxydo-reductases) monooxygenases CYP 3A4 ADMET P450 3A4 inhibitors can cause severe drug-drug interactions kln 3.80 ketoconazole [CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2] 65277-42-1 CAS Structural basis for ligand promiscuity in cytochrome P450 3A4 Ekroos M, Sjogren T Proc Natl Acad Sci U S A 103(37):13682-7 2006 10.1073/pnas.0603236103
        Enzymes         2v0m   2v0m-kln-3.80-x-2-s 26.91126 ADMET cytochrome P450 3A4 EC1.- (oxydo-reductases) monooxygenases CYP 3A4 ADMET P450 3A4 inhibitors can cause severe drug-drug interactions kln 3.80 ketoconazole [CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2] 65277-42-1 CAS Structural basis for ligand promiscuity in cytochrome P450 3A4 Ekroos M, Sjogren T Proc Natl Acad Sci U S A 103(37):13682-7 2006 10.1073/pnas.0603236103
        Enzymes         2v0m   2v0m-kln-3.80-x-2 31.19761 ADMET cytochrome P450 3A4 EC1.- (oxydo-reductases) monooxygenases CYP 3A4 ADMET P450 3A4 inhibitors can cause severe drug-drug interactions kln 3.80 ketoconazole [CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2] 65277-42-1 CAS Structural basis for ligand promiscuity in cytochrome P450 3A4 Ekroos M, Sjogren T Proc Natl Acad Sci U S A 103(37):13682-7 2006 10.1073/pnas.0603236103
2v4l PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 2v4l                                          
2v95 CBG_RAT P31211 KO_id not found Others Others Others Others Others 2v95                                          
2ves LPXC_PSEAE P47205 K02535 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides UDP-3-O-acyl-N-acetylglucosamine deacetylase 2ves                                          
2vg7 POL_HV1B1 P03366 KO_id not found Others Others Others Others Others 2vg7                                          
2vpr Q799E2_PASMD Q799E2 KO_id not found Others Others Others Others Others 2vpr                                          
2vrx AUKBA_XENLA Q6DE08 K11479 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2vrx                                          
2vvt MURI_ENTFA Q836J0 K01776 Enzymes Isomerases Racemases and epimerases Acting on amino acids and derivatives Glutamate racemase 2vvt                                          
2vwy EPHB4_HUMAN P54760 K05113 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Receptor protein-tyrosine kinase 2vwy                                          
2vx0 EPHB4_HUMAN P54760 K05113 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Receptor protein-tyrosine kinase 2vx0                                          
2vx1 EPHB4_HUMAN P54760 K05113 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Receptor protein-tyrosine kinase 2vx1                                          
2vz6 KCC2A_HUMAN Q9UQM7 K04515 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Ca2+-calmodulin-dependent protein kinase 2vz6                                          
2w1e AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2w1e                                          
2w3i FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2w3i                                          
2w4i MURI_HELPJ Q9ZLT0 K01776 Enzymes Isomerases Racemases and epimerases Acting on amino acids and derivatives Glutamate racemase 2w4i                                          
2w71 ACCC_ECOLI P24182 K01961 Enzymes Ligases Forming carbon-nitrogen bonds Other carbon-nitrogen ligases Biotin carboxylase 2w71                                          
2w98 PTGR2_HUMAN Q8N8N7 K13949 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor 15-oxoprostaglandin 13-oxidase 2w98                                          
2wd8 O76290_TRYBB O76290 KO_id not found Others Others Others Others Others 2wd8                                          
2weh CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 2weh                                          
2wek ZADH2_HUMAN Q8N4Q0 KO_id not found Others Others Others Others Others 2wek                                          
2wge FAB1_MYCTU P63454 K00921 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor 1-phosphatidylinositol-3-phosphate 5-kinase 2wge                                          
2wgg FAB1_MYCTU P63454 K00921 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor 1-phosphatidylinositol-3-phosphate 5-kinase 2wgg                                          
2wmd NMRL1_HUMAN Q9HBL8 KO_id not found Others Others Others Others Others 2wmd                                          
2wmr CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2wmr                                          
2wn9 Q8WSF8_APLCA Q8WSF8 KO_id not found Others Others Others Others Others 2wn9                                          
2wqb TIE2_HUMAN Q02763 K05121 Cellular antigens CD (clusters of differentiation) molecules CD202b; TEK tyrosine kinase, endothelial Others Others 2wqb                                          
2wu7 CLK3_HUMAN P49761 K08823 Enzymes Transferases Transferring phosphorus-containing groups Dual-specificity kinases (those acting on Ser-Thr and Tyr residues) Dual-specificity kinase 2wu7                                          
2wuf HSAD_MYCTU P96851 K16050 Enzymes Hydrolases Acting on carbon-carbon bonds In ketonic substances 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase 2wuf                                          
2wxm Q3UDT3_MOUSE Q3UDT3 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 2wxm                                          
2wxq Q3UDT3_MOUSE Q3UDT3 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 2wxq                                          
2wyg FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2wyg                                          
2wyj FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2wyj                                          
2wyw Q5SLI9_THET8 Q5SLI9 K00208 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor Enoyl-[acyl-carrier-protein] reductase (NADH) 2wyw                                          
2x00 Q8WSF8_APLCA Q8WSF8 KO_id not found Others Others Others Others Others 2x00                                          
2x1n CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 2x1n                                          
2x2m RET_HUMAN P07949 K05126 Cytokine receptors Receptor tyrosine kinase RTK class XIV (RET receptor family) RET; proto-oncogene tyrosine-protein kinase Ret Others 2x2m                                          
2x7s CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 2x7s                                          
2x7t CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 2x7t                                          
2x7u CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 2x7u                                          
2xir VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 2xir                                          
2y05 PTGR1_HUMAN Q14914 K13948 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor 15-oxoprostaglandin 13-oxidase 2y05                                          
2y7x FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2y7x                                          
2y80 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2y80                                          
2y81 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2y81                                          
2y82 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 2y82                                          
2yjd ESR2_HUMAN Q92731 K08551 Nuclear receptors Estrogen like A. Estrogen receptor NR3A2, ESR2; estrogen receptor beta Others 2yjd                                          
2ykm POL_HV1B1 P03366 KO_id not found Others Others Others Others Others 2ykm                                          
2z77 P71817_MYCTU P71817 K01822 Enzymes Isomerases Intramolecular oxidoreductases Transposing C=C bonds Steroid Delta-isomerase 2z77                                          
2zaz MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 2zaz                                          
2zb8 PTGR2_HUMAN Q8N8N7 K13949 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor 15-oxoprostaglandin 13-oxidase 2zb8                                          
2zc9 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2zc9                                          
2zd1 POL_HV1B1 P03366 KO_id not found Others Others Others Others Others 2zd1                                          
2zdv THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2zdv                                          
2zf0 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2zf0                                          
2zff THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2zff                                          
2zfp THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2zfp                                          
2zgb THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 2zgb                                          
2zjw CSK21_HUMAN P68400 K03097 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 2zjw                                          
2zm1 LCK_HUMAN P06239 K05856 CAM ligands Immunoglobulin Superfamily Immune system CD2 family CD48, BCM1; CD48 antigen [KO- ] 2zm1                                          
2zv9 LYN_MOUSE P25911 K05854 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 2zv9                                          
3a3w Q93LD7_RHIRD Q93LD7 KO_id not found Others Others Others Others Others 3a3w                                          
3a51 CPVDH_PSEAH C4B644 KO_id not found Others Others Others Others Others 3a51                                          
3ac1 LCK_HUMAN P06239 K05856 CAM ligands Immunoglobulin Superfamily Immune system CD2 family CD48, BCM1; CD48 antigen [KO- ] 3ac1                                          
3ac3 LCK_HUMAN P06239 K05856 CAM ligands Immunoglobulin Superfamily Immune system CD2 family CD48, BCM1; CD48 antigen [KO- ] 3ac3                                          
3ack LCK_HUMAN P06239 K05856 CAM ligands Immunoglobulin Superfamily Immune system CD2 family CD48, BCM1; CD48 antigen [KO- ] 3ack                                          
3ad4 LCK_HUMAN P06239 K05856 CAM ligands Immunoglobulin Superfamily Immune system CD2 family CD48, BCM1; CD48 antigen [KO- ] 3ad4                                          
3adx PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3adx                                          
3am4 Q9BJJ9_PLAFA Q9BJJ9 KO_id not found Others Others Others Others Others 3am4                                          
3am5 Q9BJJ9_PLAFA Q9BJJ9 KO_id not found Others Others Others Others Others 3am5                                          
3anq DYR1A_HUMAN Q13627 K08825 Enzymes Transferases Transferring phosphorus-containing groups Dual-specificity kinases (those acting on Ser-Thr and Tyr residues) Dual-specificity kinase 3anq                                          
3anr DYR1A_HUMAN Q13627 K08825 Enzymes Transferases Transferring phosphorus-containing groups Dual-specificity kinases (those acting on Ser-Thr and Tyr residues) Dual-specificity kinase 3anr                                          
3avp COAA_MYCTU P63810 K00867 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Pantothenate kinase 3avp                                          
3avq COAA_MYCTU P63810 K00867 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Pantothenate kinase 3avq                                          
3aza Q965D7_PLAFA Q965D7 KO_id not found Others Others Others Others Others 3aza                                          
3azb Q965D7_PLAFA Q965D7 KO_id not found Others Others Others Others Others 3azb                                          
3b2s Q9HDE2_GIBZA Q9HDE2 KO_id not found Others Others Others Others Others 3b2s                                          
3b3k PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3b3k                                          
3b67 ANDR_HUMAN P10275 K08557 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C4, AR; androgen receptor Others 3b67                                          
3b92 ADA17_HUMAN P78536 K06059 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases ADAM 17 endopeptidase 3b92                                          
3bet CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3bet                                          
3bgp PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3bgp                                          
3bgq PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3bgq                                          
3bjc PDE5A_HUMAN O76074 K13762 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 3bjc                                          
3bjh Q9U9J6_APIME Q9U9J6 KO_id not found Others Others Others Others Others 3bjh                                          
3bqm ITAL_HUMAN P20701 K05718 Cellular antigens CD (clusters of differentiation) molecules CD11a; integrin alpha L Others Others 3bqm                                          
3bqn ITAL_HUMAN P20701 K05718 Cellular antigens CD (clusters of differentiation) molecules CD11a; integrin alpha L Others Others 3bqn                                          
3bqz QACR_STAAM P0A0N3 KO_id not found Others Others Others Others Others 3bqz                                          
3bv3 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3bv3                                          
3bxs POL_HV1A2 P03369 KO_id not found Others Others Others Others Others 3bxs                                          
3byz DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3byz                                          
3bz7 MYS2_DICDI P08799 K10352 Cytoskeleton proteins Eukaryotic cytoskeleton proteins Actin filaments - Microfilaments Actin-binding proteins Myosins 3bz7                                          
3bz8 MYS2_DICDI P08799 K10352 Cytoskeleton proteins Eukaryotic cytoskeleton proteins Actin filaments - Microfilaments Actin-binding proteins Myosins 3bz8                                          
3bz9 MYS2_DICDI P08799 K10352 Cytoskeleton proteins Eukaryotic cytoskeleton proteins Actin filaments - Microfilaments Actin-binding proteins Myosins 3bz9                                          
3bzu DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3bzu                                          
3c06 TYSY_LACCA P00469 K00560 Enzymes Transferases Transferring one-carbon groups Methyltransferases Thymidylate synthase 3c06                                          
3c79 Q8WSF8_APLCA Q8WSF8 KO_id not found Others Others Others Others Others 3c79                                          
3cdp PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3cdp                                          
3cjf VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 3cjf                                          
3cpc VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 3cpc                                          
3csj GSTP1_HUMAN P09211 K00799 Enzymes Transferases Transferring alkyl or aryl groups, other than methyl groups Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) Glutathione transferase 3csj                                          
3cso POLG_HCVJ4 O92972 KO_id not found Others Others Others Others Others 3cso                                          
3cwd PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3cwd                                          
3cxi PA2B1_BOTJR Q90249 KO_id not found Others Others Others Others Others 3cxi                                          
3cy3 PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3cy3                                          
3d28 POLG_HCVBK P26663 KO_id not found Others Others Others Others Others 3d28                                          
3d3e DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3d3e                                          
3d4n DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3d4n                                          
3d5q DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3d5q                                          
3d90 PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 3d90                                          
3d9z CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3d9z                                          
3da2 CAH13_HUMAN Q8N1Q1 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3da2                                          
3da9 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3da9                                          
3dcc CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3dcc                                          
3ddp CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3ddp                                          
3ddu PPCE_HUMAN P48147 K01322 Enzymes Hydrolases Acting on peptide bonds (peptidases) Serine endopeptidases Prolyl oligopeptidase 3ddu                                          
3dhk THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3dhk                                          
3di6 POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3di6                                          
3dle POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3dle                                          
3dol POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3dol                                          
3dox POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3dox                                          
3ds6 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3ds6                                          
3dtc M3K9_HUMAN P80192 K04417 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase kinase kinase 3dtc                                          
3e2m ITAL_HUMAN P20701 K05718 Cellular antigens CD (clusters of differentiation) molecules CD11a; integrin alpha L Others Others 3e2m                                          
3e5a AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3e5a                                          
3e7v HASP_HUMAN Q8TF76 K16315 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3e7v                                          
3edz ADA17_HUMAN P78536 K06059 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases ADAM 17 endopeptidase 3edz                                          
3efl VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 3efl                                          
3egk THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3egk                                          
3ehx MMP12_HUMAN P39900 K01413 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Macrophage elastase 3ehx                                          
3ene PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 3ene                                          
3eq7 PPCE_PIG P23687 K01322 Enzymes Hydrolases Acting on peptide bonds (peptidases) Serine endopeptidases Prolyl oligopeptidase 3eq7                                          
3eq8 PPCE_PIG P23687 K01322 Enzymes Hydrolases Acting on peptide bonds (peptidases) Serine endopeptidases Prolyl oligopeptidase 3eq8                                          
3et7 FAK2_HUMAN Q14289 K05871 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 3et7                                          
3ete DHE3_BOVIN P00366 K00261 Enzymes Oxidoreductases Acting on the CH-NH2 group of donors With NAD+ or NADP+ as acceptor Glutamate dehydrogenase [NAD(P)+] 3ete                                          
3ewj ADA17_HUMAN P78536 K06059 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases ADAM 17 endopeptidase 3ewj                                          
3f16 MMP12_HUMAN P39900 K01413 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Macrophage elastase 3f16                                          
3f1q PYRD_HUMAN Q02127 K00254 Enzymes Oxidoreductases Acting on the CH-CH group of donors With a quinone or related compound as acceptor Dihydroorotate dehydrogenase (quinone) 3f1q                                          
3f4b Q6TEI5_PLABE Q6TEI5 KO_id not found Others Others Others Others Others 3f4b                                          
3f7z GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 3f7z                                          
3f88 GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 3f88                                          
3fco DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3fco                                          
3fdn AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3fdn                                          
3fei PPARA_HUMAN Q07869 K07294 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C1, PPARA; peroxisome proliferator-activated receptor alpha Others 3fei                                          
3fej PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3fej                                          
3fh7 LKHA4_HUMAN P09960 K01254 Enzymes Hydrolases Acting on ether bonds Ether hydrolases Leukotriene-A4 hydrolase 3fh7                                          
3fkn MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fkn                                          
3fko MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fko                                          
3fl4 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fl4                                          
3fln MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fln                                          
3fls MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fls                                          
3flw MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3flw                                          
3fly MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fly                                          
3flz MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3flz                                          
3fma SMY2_YEAST P32909 K11426 Chromosome Eukaryotic Type Histone modification proteins HMTs (histone methyltransferases) SMYD; SET and MYND domain-containing protein 3fma                                          
3fmh MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fmh                                          
3fmk MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fmk                                          
3fne INHA_MYCTU P0A5Y6 K05500 Lipid biosynthesis proteins TGF-beta family Distant members INHA; inhibin, alpha Others 3fne                                          
3fnf INHA_MYCTU P0A5Y6 K05500 Lipid biosynthesis proteins TGF-beta family Distant members INHA; inhibin, alpha Others 3fnf                                          
3fnu Q8IM15_PLAF7 Q8IM15 KO_id not found Others Others Others Others Others 3fnu                                          
3fqh KSYK_HUMAN P43405 K05855 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 3fqh                                          
3fqk POLG_HCVBK P26663 KO_id not found Others Others Others Others Others 3fqk                                          
3frq Q9EVJ6_ECOLX Q9EVJ6 KO_id not found Others Others Others Others Others 3frq                                          
3fsf MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fsf                                          
3fsk MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3fsk                                          
3fxw MAPK3_HUMAN Q16644 K04444 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3fxw                                          
3fzr FAK2_HUMAN Q14289 K05871 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 3fzr                                          
3fzs FAK2_HUMAN Q14289 K05871 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 3fzs                                          
3g0e KIT_HUMAN P10721 K05091 Cellular antigens CD (clusters of differentiation) molecules CD117; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Others Others 3g0e                                          
3g0u PYRD_HUMAN Q02127 K00254 Enzymes Oxidoreductases Acting on the CH-CH group of donors With a quinone or related compound as acceptor Dihydroorotate dehydrogenase (quinone) 3g0u                                          
3g0x PYRD_HUMAN Q02127 K00254 Enzymes Oxidoreductases Acting on the CH-CH group of donors With a quinone or related compound as acceptor Dihydroorotate dehydrogenase (quinone) 3g0x                                          
3g1o ETHR_MYCTU P96222 KO_id not found Others Others Others Others Others 3g1o                                          
3g45 PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3g45                                          
3g4k PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3g4k                                          
3g7e C3SLN3_ECOLX C3SLN3 KO_id not found Others Others Others Others Others 3g7e                                          
3g8o PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 3g8o                                          
3gbk PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3gbk                                          
3gki NPC1_HUMAN O15118 K12385 Others Cellular Processes Transport and catabolism Lysosome NPC1; Niemann-Pick C1 protein 3gki                                          
3gkj NPC1_HUMAN O15118 K12385 Others Cellular Processes Transport and catabolism Lysosome NPC1; Niemann-Pick C1 protein 3gkj                                          
3gko URIC_ASPFL Q00511 K00365 Enzymes Oxidoreductases Acting on other nitrogenous compounds as donors With oxygen as acceptor Factor-independent urate hydroxylase 3gko                                          
3gn2 O76290_TRYBB O76290 KO_id not found Others Others Others Others Others 3gn2                                          
3gnv POLG_HCVJ4 O92972 KO_id not found Others Others Others Others Others 3gnv                                          
3gql FGFR1_HUMAN P11362 K04362 Heparan sulfate-heparin binding proteins Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis FGFR1; fibroblast growth factor receptor 1 Mitogenesis Others Others 3gql                                          
3h0y AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3h0y                                          
3h3c FAK2_HUMAN Q14289 K05871 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 3h3c                                          
3h5u POLG_HCVBK P26663 KO_id not found Others Others Others Others Others 3h5u                                          
3h6k DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3h6k                                          
3h98 POLG_HCVBK P26663 KO_id not found Others Others Others Others Others 3h98                                          
3ha6 AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3ha6                                          
3hbb Q8T5T8_TRYCR Q8T5T8 KO_id not found Others Others Others Others Others 3hbb                                          
3hgy Q7B8P6_CAMJU Q7B8P6 KO_id not found Others Others Others Others Others 3hgy                                          
3hlj CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3hlj                                          
3hlv ESR1_HUMAN P03372 K08550 Nuclear receptors Estrogen like A. Estrogen receptor NR3A1, ESR1; estrogen receptor alpha Others 3hlv                                          
3hmp TTK_HUMAN P33981 K08866 Enzymes Transferases Transferring phosphorus-containing groups Dual-specificity kinases (those acting on Ser-Thr and Tyr residues) Dual-specificity kinase 3hmp                                          
3hmv PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3hmv                                          
3hng VGFR1_HUMAN P17948 K05096 Cytokine receptors Receptor tyrosine kinase RTK class V (VEGF receptor family) FLT1, VEGFR1; FMS-like tyrosine kinase 1 Others 3hng                                          
3ho0 PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3ho0                                          
3hod PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3hod                                          
3hp2 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3hp2                                          
3hp5 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3hp5                                          
3hqy PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3hqy                                          
3hqz PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3hqz                                          
3hr1 PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3hr1                                          
3hrb MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3hrb                                          
3hrr PKSL1_ASPPA Q12053 KO_id not found Others Others Others Others Others 3hrr                                          
3hx3 RLBP1_HUMAN P12271 KO_id not found Others Others Others Others Others 3hx3                                          
3i7c Q9BJF5_TOXGO Q9BJF5 KO_id not found Others Others Others Others Others 3i7c                                          
3i81 IGF1R_HUMAN P08069 K05087 Cellular antigens CD (clusters of differentiation) molecules CD221; insulin-like growth factor 1 receptor Others Others 3i81                                          
3i8v PDE4A_HUMAN P27815 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3i8v                                          
3i9l NADA_APLCA P29241 K03517 Enzymes Transferases Transferring alkyl or aryl groups, other than methyl groups Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) Quinolinate synthase 3i9l                                          
3iak PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3iak                                          
3iej CATS_HUMAN P25774 K01368 Enzymes Hydrolases Acting on peptide bonds (peptidases) Cysteine endopeptidases Cathepsin S 3iej                                          
3ig7 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3ig7                                          
3ihg Q54530_9ACTO Q54530 KO_id not found Others Others Others Others Others 3ihg                                          
3ik6 GRIA2_RAT P19491 K05198 Ion Channels Glutamate-gated cation channels Glutamate (ionotropic), non-NMDA GRIA2; glutamate receptor 2 Others 3ik6                                          
3il5 FABH_ENTFA Q820T1 K00648 Enzymes Transferases Acyltransferases Transferring groups other than aminoacyl groups Beta-ketoacyl-acyl-carrier-protein synthase III 3il5                                          
3imx Q53Y25_HUMAN Q53Y25 K12407 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Glucokinase 3imx                                          
3ip8 AMDA_BORBO Q05115 KO_id not found Others Others Others Others Others 3ip8                                          
3iub PANC_MYCTU P0A5R0 K01918 Enzymes Ligases Forming carbon-nitrogen bonds Acid-D-amino-acid ligases (peptide synthases) Pantoate---beta-alanine ligase 3iub                                          
3ivm Q9X6R4_AERPU Q9X6R4 KO_id not found Others Others Others Others Others 3ivm                                          
3iw5 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3iw5                                          
3ix8 LASR_PSEAE P25084 KO_id not found Others Others Others Others Others 3ix8                                          
3jpv PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3jpv                                          
3jq8 Q581W1_TRYB2 Q581W1 K03793 Enzymes Oxidoreductases Acting on the CH-NH group of donors With NAD+ or NADP+ as acceptor Pteridine reductase 3jq8                                          
3jsx NQO1_HUMAN P15559 K00355 Enzymes Oxidoreductases Acting on NADH or NADPH With a quinone or similar compound as acceptor NAD(P)H dehydrogenase (quinone) 3jsx                                          
3jtk NMT1_HUMAN P30419 K00671 Enzymes Transferases Acyltransferases Transferring groups other than aminoacyl groups Glycylpeptide N-tetradecanoyltransferase 3jtk                                          
3jya PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3jya                                          
3k3h PDE9A_HUMAN O76083 K13761 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 3k3h                                          
3k3j MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3k3j                                          
3k4s PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3k4s                                          
3k6p ERR1_HUMAN P11474 K01689 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Phosphopyruvate hydratase 3k6p                                          
3kba PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 3kba                                          
3kcf TGFR1_HUMAN P36897 K04674 Cytokine receptors TGF-beta receptors Type I TGF-beta receptor TGFBR1; TGF-beta receptor type-1 Others 3kcf                                          
3kf7 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3kf7                                          
3khj Q5CPK7_CRYPI Q5CPK7 K00088 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor IMP dehydrogenase 3khj                                          
3ki3 CHXA_VIBCL Q5EK40 KO_id not found Others Others Others Others Others 3ki3                                          
3ki4 CHXA_VIBCL Q5EK40 KO_id not found Others Others Others Others Others 3ki4                                          
3ki5 CHXA_VIBCL Q5EK40 KO_id not found Others Others Others Others Others 3ki5                                          
3ki6 CHXA_VIBCL Q5EK40 KO_id not found Others Others Others Others Others 3ki6                                          
3kig CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3kig                                          
3kkt PDE4B_HUMAN Q07343 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3kkt                                          
3km0 DHB1_HUMAN P14061 K00044 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Estradiol 17beta-dehydrogenase 3km0                                          
3kn0 BACE1_HUMAN P56817 K04521 Enzymes Hydrolases Acting on peptide bonds (peptidases) Aspartic endopeptidases Memapsin 2 3kn0                                          
3kti CLPP_BACSU P80244 K01358 Enzymes Hydrolases Acting on peptide bonds (peptidases) Serine endopeptidases Endopeptidase Clp 3kti                                          
3l08 PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 3l08                                          
3l30 PA21B_PIG P00592 K01047 Enzymes Hydrolases Acting on ester bonds Carboxylic-ester hydrolases Phospholipase A2 3l30                                          
3l3l PARP1_HUMAN P09874 K10798 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 3l3l                                          
3l54 PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 3l54                                          
3l5r MIF_HUMAN P14174 K07253 Enzymes Isomerases Intramolecular oxidoreductases Interconverting keto- and enol-groups Phenylpyruvate tautomerase 3l5r                                          
3l8p TIE2_HUMAN Q02763 K05121 Cellular antigens CD (clusters of differentiation) molecules CD202b; TEK tyrosine kinase, endothelial Others Others 3l8p                                          
3l8w URIC_ASPFL Q00511 K00365 Enzymes Oxidoreductases Acting on other nitrogenous compounds as donors With oxygen as acceptor Factor-independent urate hydroxylase 3l8w                                          
3l9h KIF11_HUMAN P52732 K10398 Cytoskeleton proteins Eukaryotic cytoskeleton proteins Microtubules Tubulin-binding proteins KIF11; kinesin family member 11 3l9h                                          
3lal POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3lal                                          
3ld4 URIC_ASPFL Q00511 K00365 Enzymes Oxidoreductases Acting on other nitrogenous compounds as donors With oxygen as acceptor Factor-independent urate hydroxylase 3ld4                                          
3le6 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3le6                                          
3lka MMP12_HUMAN P39900 K01413 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Macrophage elastase 3lka                                          
3lkh POLG_HCVJ4 O92972 KO_id not found Others Others Others Others Others 3lkh                                          
3lmp PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3lmp                                          
3ln0 PGH2_MOUSE Q05769 K11987 Enzymes Oxidoreductases Acting on paired donors with incorporation of molecular oxygen Miscellaneous Prostaglandin-endoperoxide synthase 3ln0                                          
3lpf BGLR_ECOLI P05804 K01195 Enzymes Hydrolases Glycosylases Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds Beta-glucuronidase 3lpf                                          
3lq5 CDK9_HUMAN P50750 K02211 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3lq5                                          
3lt0 Q9BJJ9_PLAFA Q9BJJ9 KO_id not found Others Others Others Others Others 3lt0                                          
3lxg PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3lxg                                          
3m2w MAPK2_HUMAN P49137 K04443 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3m2w                                          
3m42 MAPK2_HUMAN P49137 K04443 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3m42                                          
3m67 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3m67                                          
3m7u PRLA_LYSEN P00778 KO_id not found Others Others Others Others Others 3m7u                                          
3mcv O76290_TRYBB O76290 KO_id not found Others Others Others Others Others 3mcv                                          
3mdy BMR1B_HUMAN O00238 K13578 Cellular antigens CD (clusters of differentiation) molecules CDw293; bone morphogenetic protein receptor, type IB Others Others 3mdy                                          
3mdz CAH7_HUMAN P43166 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3mdz                                          
3mee POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3mee                                          
3meg POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3meg                                          
3mhj TNKS2_HUMAN Q9H2K2 K10799 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 3mhj                                          
3mhk TNKS2_HUMAN Q9H2K2 K10799 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 3mhk                                          
3mla NADD_BACAC C3L5T6 K00969 Enzymes Transferases Transferring phosphorus-containing groups Nucleotidyltransferases Nicotinate-nucleotide adenylyltransferase 3mla                                          
3mpt MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3mpt                                          
3mqe PGH2_MOUSE Q05769 K11987 Enzymes Oxidoreductases Acting on paired donors with incorporation of molecular oxygen Miscellaneous Prostaglandin-endoperoxide synthase 3mqe                                          
3mtl CDK16_HUMAN Q00536 K08820 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3mtl                                          
3my0 ACVL1_HUMAN P37023 K13594 Cytokine receptors TGF-beta receptors Type I TGF-beta receptor ACVRL1; activin receptor-like kinase 1 Others 3my0                                          
3my5 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3my5                                          
3mzs CP11A_BOVIN P00189 K00498 Cytochrome P450 Cytochrome P450, animal type CYP11 family CYP11A subfamily Cholesterol side-chain cleavage enzyme 3mzs 9913                                        
3n8y PGH1_SHEEP P05979 K00509 Enzymes Oxidoreductases Acting on paired donors with incorporation of molecular oxygen Miscellaneous Prostaglandin-endoperoxide synthase 3n8y                                          
3n9y CP11A_HUMAN P05108 K00498 Cytochrome P450 Cytochrome P450, animal type CYP11 family CYP11A subfamily Cholesterol side-chain cleavage enzyme 3n9y 9606                                        
3na1 CP11A_HUMAN P05108 K00498 Cytochrome P450 Cytochrome P450, animal type CYP11 family CYP11A subfamily CYP11A; cytochrome P450, family 11, subfamily A (cholesterol monooxygenase (side-chain-cleaving)) 3na1                                          
3nbp POL_HV1H2 P04585 KO_id not found Others Others Others Others Others 3nbp                                          
3ncg A3FQ16_CRYPI A3FQ16 K13412 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3ncg                                          
3nef PYL1_ARATH Q8VZS8 KO_id not found Others Others Others Others Others 3nef                                          
3nf6 Q76353_9HIV1 Q76353 KO_id not found Others Others Others Others Others 3nf6                                          
3nj8 Q6UCJ9_TOXGO Q6UCJ9 K00208 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor Enoyl-[acyl-carrier-protein] reductase (NADH) 3nj8                                          
3njo PYR1_ARATH O49686 K11540 Enzymes Transferases Transferring one-carbon groups Carboxy- and carbamoyltransferases Aspartate carbamoyltransferase 3njo                                          
3nmh PYL2_ARATH O80992 KO_id not found Others Others Others Others Others 3nmh                                          
3nmn PYL1_ARATH Q8VZS8 KO_id not found Others Others Others Others Others 3nmn                                          
3nrc Q5NGQ3_FRATT Q5NGQ3 K00208 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor Enoyl-[acyl-carrier-protein] reductase (NADH) 3nrc                                          
3ns2 PYL2_ARATH O80992 KO_id not found Others Others Others Others Others 3ns2                                          
3ns9 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3ns9                                          
3ny6 CHXA_VIBCL Q5EK40 KO_id not found Others Others Others Others Others 3ny6                                          
3nyv Q9BJF5_TOXGO Q9BJF5 KO_id not found Others Others Others Others Others 3nyv                                          
3o23 IGF1R_HUMAN P08069 K05087 Cellular antigens CD (clusters of differentiation) molecules CD221; insulin-like growth factor 1 receptor Others Others 3o23                                          
3o2f ENPL_CANFA P41148 K09487 Chaperones and folding catalysts Heat shock proteins HSP90 K09487 HSP90B, TRA1; heat shock protein 90kDa beta Endoplasmic reticulum 3o2f                                          
3o3j DEF1B_ARATH Q9FUZ2 K01462 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides Peptide deformylase 3o3j                                          
3o5r FKBP5_HUMAN Q13451 K09571 Enzymes Isomerases Cis-trans-Isomerases Cis-trans Isomerases (only sub-subclass identified to date) Peptidylprolyl isomerase 3o5r                                          
3oax OPSD_BOVIN P02699 K04250 G protein-coupled receptors Class A. Rhodopsin family Vision Opsin RHO, OPN2; rhodopsin 3oax                                          
3ohl MMP3_HUMAN P08254 K01394 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Stromelysin 1 3ohl                                          
3oho MMP3_HUMAN P08254 K01394 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Stromelysin 1 3oho                                          
3oik CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3oik                                          
3oil CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3oil                                          
3oim CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3oim                                          
3oku CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3oku                                          
3okv CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3okv                                          
3omo ESR2_HUMAN Q92731 K08551 Nuclear receptors Estrogen like A. Estrogen receptor NR3A2, ESR2; estrogen receptor beta Others 3omo                                          
3omp ESR2_HUMAN Q92731 K08551 Nuclear receptors Estrogen like A. Estrogen receptor NR3A2, ESR2; estrogen receptor beta Others 3omp                                          
3oom ACVR1_HUMAN Q04771 K04675 Cytokine receptors TGF-beta receptors Type I TGF-beta receptor ACVR1; activin receptor type-1 Others 3oom                                          
3oq1 DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3oq1                                          
3os9 ESR1_HUMAN P03372 K08550 Nuclear receptors Estrogen like A. Estrogen receptor NR3A1, ESR1; estrogen receptor alpha Others 3os9                                          
3osa ESR1_HUMAN P03372 K08550 Nuclear receptors Estrogen like A. Estrogen receptor NR3A1, ESR1; estrogen receptor alpha Others 3osa                                          
3osh PA2A3_NAJSG P60045 KO_id not found Others Others Others Others Others 3osh                                          
3osi PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3osi                                          
3osw PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3osw                                          
3ov4 SDIS_COMTE P00947 KO_id not found Others Others Others Others Others 3ov4                                          
3ovv KAPCA_HUMAN P17612 K04345 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases CAMP-dependent protein kinase 3ovv                                          
3ox1 NQO2_HUMAN P16083 K08071 Enzymes Oxidoreductases Acting on diphenols and related substances as donors With other acceptors Ribosyldihydronicotinamide dehydrogenase (quinone) 3ox1                                          
3ox3 NQO2_HUMAN P16083 K08071 Enzymes Oxidoreductases Acting on diphenols and related substances as donors With other acceptors Ribosyldihydronicotinamide dehydrogenase (quinone) 3ox3                                          
3ozu HMP_CUPNH P39662 K05916 Enzymes Oxidoreductases Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor Nitric oxide dioxygenase 3ozu                                          
3ozv HMP_CUPNH P39662 K05916 Enzymes Oxidoreductases Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor Nitric oxide dioxygenase 3ozv                                          
3p17 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3p17                                          
3p1f CBP_HUMAN Q92793 K04498 Chromosome Eukaryotic Type Histone modification proteins HATs (histone acetyltransferases) EP300, CREBBP, KAT3; E1A-CREB-binding protein 3p1f                                          
3p2v ALDR_HUMAN P15121 K00011 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Aldehyde reductase 3p2v                                          
3p86 CTR1_ARATH Q05609 K14510 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3p86                                          
3p9t Q8KLP4_STEMA Q8KLP4 KO_id not found Others Others Others Others Others 3p9t                                          
3pb7 QPCTL_HUMAN Q9NXS2 KO_id not found Others Others Others Others Others 3pb7                                          
3pbb QPCT_HUMAN Q16769 K00683 Enzymes Transferases Acyltransferases Aminoacyltransferases Glutaminyl-peptide cyclotransferase 3pbb                                          
3pcu RXRA_HUMAN P19793 K08524 Nuclear receptors Hepatocyte nuclear factor 4 like B. Retinoid X receptor (RXR) NR2B1, RXRA; retinoid X receptor alpha Others 3pcu                                          
3pej Q8I0V4_PLAF7 Q8I0V4 KO_id not found Others Others Others Others Others 3pej                                          
3pfb D3YEX6_LACJH D3YEX6 KO_id not found Others Others Others Others Others 3pfb                                          
3pgq ACAC_YEAST Q00955 K11262 Enzymes Ligases Forming carbon-nitrogen bonds Other carbon-nitrogen ligases Biotin carboxylase 3pgq                                          
3pj8 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3pj8                                          
3pkg URIC_ASPFL Q00511 K00365 Enzymes Oxidoreductases Acting on other nitrogenous compounds as donors With oxygen as acceptor Factor-independent urate hydroxylase 3pkg                                          
3po6 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3po6                                          
3po7 AOFB_HUMAN P27338 K00274 Enzymes Oxidoreductases Acting on the CH-NH2 group of donors With oxygen as acceptor Monoamine oxidase 3po7                                          
3poz EGFR_HUMAN P00533 K04361 Cytokine receptors Receptor tyrosine kinase RTK class I (EGF receptor family) EGFR, ERBB1; epidermal growth factor receptor Others 3poz                                          
3ppm FAAH1_RAT P97612 K15528 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides Fatty acid amide hydrolase 3ppm                                          
3ps6 PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 3ps6                                          
3q2f BAZ2B_HUMAN Q9UIF8 KO_id not found Others Others Others Others Others 3q2f                                          
3q2m O06916_LEGPN O06916 KO_id not found Others Others Others Others Others 3q2m                                          
3q3s ETHR_MYCTU P96222 KO_id not found Others Others Others Others Others 3q3s                                          
3q4t AVR2A_HUMAN P27037 K04670 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Receptor protein serine-threonine kinase 3q4t                                          
3q6w MET_HUMAN P08581 K05099 Cellular antigens Non-CD molecules MET; met proto-oncogene (hepatocyte growth factor receptor) Others Others 3q6w                                          
3q77 ELNE_HUMAN P08246 K01327 Heparan sulfate-heparin binding proteins Enzymes(General comment) Variety ELANE; leukocyte elastase Protection from inactivation by serpins Others Others 3q77                                          
3qck PTPRG_HUMAN P23470 K01104 Others Hydrolases Acting on ester bonds Phosphoric-monoester hydrolases Protein-tyrosine-phosphatase 3qck                                          
3qiz BXA1_CLOBH A5HZZ9 K06011 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Bontoxilysin 3qiz                                          
3qj9 FAAH1_RAT P97612 K15528 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides Fatty acid amide hydrolase 3qj9                                          
3qjz PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 3qjz                                          
3qk5 FAAH1_RAT P97612 K15528 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides Fatty acid amide hydrolase 3qk5                                          
3qp2 D3W065_CHRVL D3W065 KO_id not found Others Others Others Others Others 3qp2                                          
3qp4 D3W065_CHRVL D3W065 KO_id not found Others Others Others Others Others 3qp4                                          
3qpn PDE10_RAT Q9QYJ6 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3qpn                                          
3qqp DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3qqp                                          
3qsa TRPD_MYCTU P66992 K00766 Enzymes Transferases Glycosyltransferases Pentosyltransferases Anthranilate phosphoribosyltransferase 3qsa                                          
3qti MET_HUMAN P08581 K05099 Cellular antigens Non-CD molecules MET; met proto-oncogene (hepatocyte growth factor receptor) Others Others 3qti                                          
3qud MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3qud                                          
3qwc THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3qwc                                          
3qx4 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3qx4                                          
3qx5 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3qx5                                          
3qzh CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3qzh                                          
3qzi CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3qzi                                          
3r1s CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3r1s                                          
3r1y CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3r1y                                          
3r21 AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3r21                                          
3r22 AURKA_HUMAN O14965 K11481 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3r22                                          
3r28 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3r28                                          
3r2y MAPK2_HUMAN P49137 K04443 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3r2y                                          
3r43 AK1C3_HUMAN P42330 K00089 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 3alpha-hydroxysteroid dehydrogenase (A-specific) 3r43                                          
3r5m RXRA_HUMAN P19793 K08524 Nuclear receptors Hepatocyte nuclear factor 4 like B. Retinoid X receptor (RXR) NR2B1, RXRA; retinoid X receptor alpha Others 3r5m                                          
3r6i AK1C3_HUMAN P42330 K00089 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 3alpha-hydroxysteroid dehydrogenase (A-specific) 3r6i                                          
3r71 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3r71                                          
3r73 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3r73                                          
3r7o MET_HUMAN P08581 K05099 Cellular antigens Non-CD molecules MET; met proto-oncogene (hepatocyte growth factor receptor) Others Others 3r7o                                          
3r7r PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 3r7r                                          
3r7v CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3r7v                                          
3r8h AK1C3_HUMAN P42330 K00089 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 3alpha-hydroxysteroid dehydrogenase (A-specific) 3r8h                                          
3rgz BRI1_ARATH O22476 K13415 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Receptor protein-tyrosine kinase 3rgz                                          
3rhx FGFR1_HUMAN P11362 K04362 Heparan sulfate-heparin binding proteins Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis FGFR1; fibroblast growth factor receptor 1 Mitogenesis Others Others 3rhx                                          
3ri1 FGFR2_HUMAN P21802 K05093 Heparan sulfate-heparin binding proteins Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis FGFR2; fibroblast growth factor receptor 2 Mitogenesis Others Others 3ri1                                          
3roc MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3roc                                          
3roy CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3roy                                          
3rz3 UB2R1_HUMAN P49427 K02207 Enzymes Ligases Forming carbon-nitrogen bonds Acid-D-amino-acid ligases (peptide synthases) Ubiquitin---protein ligase 3rz3                                          
3s2a PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 3s2a                                          
3s3g ALDR_HUMAN P15121 K00011 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor Aldehyde reductase 3s3g                                          
3s3i MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3s3i                                          
3s71 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3s71                                          
3s72 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3s72                                          
3s73 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3s73                                          
3s74 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3s74                                          
3s76 CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3s76                                          
3sax CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3sax                                          
3say GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 3say                                          
3sha THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3sha                                          
3shc THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3shc                                          
3shz PDE5A_HUMAN O76074 K13762 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 3shz                                          
3si3 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3si3                                          
3si4 THRB_HUMAN P00734 K01313 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F2; coagulation factor II (thrombin) Others Others 3si4                                          
3sie PDE5A_HUMAN O76074 K13762 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 3sie                                          
3sl8 PDE4D_HUMAN Q08499 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3sl8                                          
3smj PAR14_HUMAN Q460N5 K15261 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 3smj                                          
3sni PDE10_HUMAN Q9Y233 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3sni                                          
3srb PVDQ_PSEAE Q9I194 K07116 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides Acyl-homoserine-lactone acylase 3srb                                          
3sw2 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 3sw2                                          
3sw4 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3sw4                                          
3sw7 CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3sw7                                          
3t03 PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3t03                                          
3t5z CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 3t5z                                          
3t94 MTAP_SULSO Q97W94 K00772 Enzymes Transferases Glycosyltransferases Pentosyltransferases S-methyl-5'-thioadenosine phosphorylase 3t94                                          
3t9i PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3t9i                                          
3tfq DHI1_HUMAN P28845 K15680 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 11beta-hydroxysteroid dehydrogenase 3tfq                                          
3tge PDE5A_HUMAN O76074 K13762 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-GMP phosphodiesterase 3tge                                          
3tiz CDK2_HUMAN P24941 K02206 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Cyclin-dependent kinase 3tiz                                          
3tk6 FA10_HUMAN P00742 K01314 Heparan sulfate-heparin binding proteins Coagulation and fibrinolysis(General comment) Coagulation, inflammation, complement control F10; coagulation factor X Others Others 3tk6                                          
3ts4 MMP12_HUMAN P39900 K01413 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Macrophage elastase 3ts4                                          
3tt4 MMP8_HUMAN P22894 K01402 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Neutrophil collagenase 3tt4                                          
3tv5 ACAC_YEAST Q00955 K11262 Enzymes Ligases Forming carbon-nitrogen bonds Other carbon-nitrogen ligases Biotin carboxylase 3tv5                                          
3tvw ACAC_YEAST Q00955 K11262 Enzymes Ligases Forming carbon-nitrogen bonds Other carbon-nitrogen ligases Biotin carboxylase 3tvw                                          
3ty0 PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3ty0                                          
3tz3 ACAC_YEAST Q00955 K11262 Enzymes Ligases Forming carbon-nitrogen bonds Other carbon-nitrogen ligases Biotin carboxylase 3tz3                                          
3tzm TGFR1_HUMAN P36897 K04674 Cytokine receptors TGF-beta receptors Type I TGF-beta receptor TGFBR1; TGF-beta receptor type-1 Others 3tzm                                          
3u1y LPXC_PSEAE P47205 K02535 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides UDP-3-O-acyl-N-acetylglucosamine deacetylase 3u1y                                          
3u6h MET_HUMAN P08581 K05099 Cellular antigens Non-CD molecules MET; met proto-oncogene (hepatocyte growth factor receptor) Others Others 3u6h                                          
3ua9 TNKS2_HUMAN Q9H2K2 K10799 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 3ua9                                          
3udd TNKS1_HUMAN O95271 K10799 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 3udd                                          
3ugr AK1C3_HUMAN P42330 K00089 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 3alpha-hydroxysteroid dehydrogenase (A-specific) 3ugr                                          
3uh2 TNKS1_HUMAN O95271 K10799 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 3uh2                                          
3uhm LPXC_PSEAE P47205 K02535 Enzymes Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In linear amides UDP-3-O-acyl-N-acetylglucosamine deacetylase 3uhm                                          
3ui7 PDE10_HUMAN Q9Y233 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3ui7                                          
3uuo PDE10_HUMAN Q9Y233 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 3uuo                                          
3v9t PPARG_HUMAN P37231 K08530 Nuclear receptors Thyroid hormone like C. Peroxisome proliferator-activated receptor (PPAR) NR1C3, PPARG; peroxisome proliferator-activated receptor gamma Others 3v9t                                          
3vc4 PIM1_HUMAN P11309 K04702 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3vc4                                          
3vid VGFR2_HUMAN P35968 K05098 Cellular antigens CD (clusters of differentiation) molecules CD309; kinase insert domain receptor Others Others 3vid                                          
3zr7 PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 3zr7                                          
3zra PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 3zra                                          
3zrl GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 3zrl                                          
3zrm GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 3zrm                                          
3zsh MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3zsh                                          
3zsi MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3zsi                                          
3ztx AUKBA_XENLA Q6DE08 K11479 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 3ztx                                          
3zws PYRD_HUMAN Q02127 K00254 Enzymes Oxidoreductases Acting on the CH-CH group of donors With a quinone or related compound as acceptor Dihydroorotate dehydrogenase (quinone) 3zws                                          
3zwt PYRD_HUMAN Q02127 K00254 Enzymes Oxidoreductases Acting on the CH-CH group of donors With a quinone or related compound as acceptor Dihydroorotate dehydrogenase (quinone) 3zwt                                          
3zya MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 3zya                                          
4a2j PRGR_HUMAN P06401 K08556 Nuclear receptors Estrogen like C. 3-Ketosteroid receptor NR3C3, PGR; progesterone receptor Others 4a2j                                          
4a79 AOFB_HUMAN P27338 K00274 Enzymes Oxidoreductases Acting on the CH-NH2 group of donors With oxygen as acceptor Monoamine oxidase 4a79                                          
4aa4 MK14_HUMAN Q16539 K04441 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 4aa4                                          
4ael PDE10_HUMAN Q9Y233 K01120 Enzymes Hydrolases Acting on ester bonds Phosphoric-diester hydrolases 3',5'-cyclic-nucleotide phosphodiesterase 4ael                                          
4af3 AURKB_HUMAN Q96GD4 K11479 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4af3                                          
4afj GSK3B_HUMAN P49841 K03083 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Tau-protein kinase 4afj                                          
4aid PNP_CAUCR Q9AC32 K00962 Enzymes Transferases Transferring phosphorus-containing groups Nucleotidyltransferases Polyribonucleotide nucleotidyltransferase 4aid                                          
4aj1 LDHA_RAT P04642 K00016 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor L-lactate dehydrogenase 4aj1                                          
4ajw PK3CD_MOUSE O35904 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 4ajw                                          
4all Q7A6D8_STAAN Q7A6D8 K00208 Enzymes Oxidoreductases Acting on the CH-CH group of donors With NAD+ or NADP+ as acceptor Enoyl-[acyl-carrier-protein] reductase (NADH) 4all                                          
4anv PK3CG_HUMAN P48736 K00922 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Phosphatidylinositol-4,5-bisphosphate 3-kinase 4anv                                          
4aoj NTRK1_HUMAN P04629 K03176 Cytokine receptors Receptor tyrosine kinase RTK class VII (TRK receptor family) NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1 Others 4aoj                                          
4at4 NTRK2_HUMAN Q16620 K04360 Cytokine receptors Receptor tyrosine kinase RTK class VII (TRK receptor family) NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2 Others 4at4                                          
4aw5 EPHB4_HUMAN P54760 K05113 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Receptor protein-tyrosine kinase 4aw5                                          
4dbs AK1C3_HUMAN P42330 K00089 Enzymes Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor 3alpha-hydroxysteroid dehydrogenase (A-specific) 4dbs                                          
4dch HXK4_HUMAN P35557 K12407 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Glucokinase 4dch                                          
4deg MET_HUMAN P08581 K05099 Cellular antigens Non-CD molecules MET; met proto-oncogene (hepatocyte growth factor receptor) Others Others 4deg                                          
4drk FKBP5_HUMAN Q13451 K09571 Enzymes Isomerases Cis-trans-Isomerases Cis-trans Isomerases (only sub-subclass identified to date) Peptidylprolyl isomerase 4drk                                          
4dvi TNKS1_HUMAN O95271 K10799 Enzymes Transferases Glycosyltransferases Pentosyltransferases NAD+ ADP-ribosyltransferase 4dvi                                          
4e3f CAH2_HUMAN P00918 K01672 Enzymes Lyases Carbon-oxygen lyases Hydro-lyases Carbonate dehydratase 4e3f                                          
4ebw FAK1_HUMAN Q05397 K05725 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 4ebw                                          
4efs MMP12_HUMAN P39900 K01413 Enzymes Hydrolases Acting on peptide bonds (peptidases) Metalloendopeptidases Macrophage elastase 4efs                                          
4ei4 JAK1_HUMAN P23458 K11217 Enzymes Transferases Transferring phosphorus-containing groups Protein-tyrosine kinases Non-specific protein-tyrosine kinase 4ei4                                          
4erk MK01_RAT P63086 K04371 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Mitogen-activated protein kinase 4erk                                          
4f4s ATP9_YEAST P61829 K02128 Enzymes Hydrolases Acting on acid anhydrides Acting on acid anhydrides to catalyse transmembrane movement of substances H+-transporting two-sector ATPase 4f4s                                          
4f63 FGFR1_HUMAN P11362 K04362 Heparan sulfate-heparin binding proteins Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis FGFR1; fibroblast growth factor receptor 1 Mitogenesis Others Others 4f63                                          
4f65 FGFR1_HUMAN P11362 K04362 Heparan sulfate-heparin binding proteins Growth factors-receptors(General comment) Ligand-receptor clustering and signaling, cell migration, mitogenesis FGFR1; fibroblast growth factor receptor 1 Mitogenesis Others Others 4f65                                          
4fai Q86PD7_DROME Q86PD7 K00683 Enzymes Transferases Acyltransferases Aminoacyltransferases Glutaminyl-peptide cyclotransferase 4fai                                          
4fev B0VD92_ACIBY B0VD92 K00897 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Kanamycin kinase 4fev                                          
4few B0VD92_ACIBY B0VD92 K00897 Enzymes Transferases Transferring phosphorus-containing groups Phosphotransferases with an alcohol group as acceptor Kanamycin kinase 4few                                          
4fob ALK_HUMAN Q9UM73 K05119 Cellular antigens CD (clusters of differentiation) molecules CD246; anaplastic lymphoma kinase Others Others 4fob                                          
4foc ALK_HUMAN Q9UM73 K05119 Cellular antigens CD (clusters of differentiation) molecules CD246; anaplastic lymphoma kinase Others Others 4foc                                          
4fsm CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4fsm                                          
4fsq CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4fsq                                          
4fsw CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4fsw                                          
4ft3 CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4ft3                                          
4ftj CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4ftj                                          
4ftt CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4ftt                                          
4ftu CHK1_HUMAN O14757 K02216 Enzymes Transferases Transferring phosphorus-containing groups Protein-serine-threonine kinases Non-specific serine-threonine protein kinase 4ftu                                          
4g55 CLH1_HUMAN Q00610 K08099 Enzymes Hydrolases Acting on ester bonds Carboxylic-ester hydrolases Chlorophyllase 4g55